Effects of cocaine self-administration history under limited and extended access conditions on in vivo striatal dopamine neurochemistry and acoustic startle in rhesus monkeys
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Rationale The transition from infrequent and controlled cocaine use to dependence may involve enduring changes in neurobiology as a consequence of persistent drug use.Objective The present study utilized an intravenous drug self-administration protocol of increasing cocaine access to evaluate potential changes in dopamine function in vivo, including changes in sensitivity to psychostimulants.Materials and methods Drug-naïve rhesus monkeys were provided limited access (1 h) to cocaine self-administration for 60 days followed by 60 days under an extended access condition (4 h). Basal levels of striatal extracellular dopamine and its metabolites, as well as the effectiveness of cocaine and amphetamine to elevate dopamine, were determined with in vivo microdialysis before the initiation of cocaine self-administration and during limited and extended access. The effect of cocaine and amphetamine on the acoustic startle response was also examined to assess complementary behavioral changes as a function of drug history.Results Extended access to cocaine self-administration lead to increased daily intake compared to limited access conditions but did not result in escalated intake over time. However, cocaine- and amphetamine-induced increases in striatal dopamine were diminished as a function of cocaine self-administration history. Surprisingly, there was no effect of drug-taking history on sensitivity to psychostimulant-induced enhancement of startle amplitude.Conclusions The present experiments provide evidence of a hypofunctional dopamine system that is not associated with an escalation in drug intake or reflected in measures of acoustic startle.
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Dopamine levels are decreased in animals chronically exposed to drugs of abuse.
“Dopamine levels are decreased in animals chronically exposed to drugs of abuse (Castner et al., 2000; Kirkland Henry et al., 2009; Lee et al., 2011; Maisonneuve et al., 1995; Melega et al., 2008; Segal and Kuczenski, 1992; Sorg et al., 1997).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Kirkland Henry et al., 2009
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Cites
Addiction Is a Brain Disease, and It Matters
Leshner, A. I. (1997) · Science · doi:10.1126/science.278.5335.45 · Cited by 1,615 · see citing works
Fear and anxiety: Animal models and human cognitive psychophysiology
Lang, P. J., Davis, M., & Öhman, A. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00343-8 · Cited by 1,162 · see citing works
Self-citationTransition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point
Ahmed, S. H., & Koob, G. F. (1998) · Science · doi:10.1126/science.282.5387.298 · Cited by 1,159 · see citing works
A primary acoustic startle circuit: lesion and stimulation studies
Davis, M., Gendelman, D. S., Tischler, M., & Gendelman, P. M. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-06-00791.1982 · Cited by 967 · see citing works
Self-citationDecreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688 · see citing works
Monoamine transporters and psychostimulant drugs.
Rothman, R., & Baumann, M. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.054 · Cited by 509 · see citing works
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.6.719 · Cited by 421 · see citing works
Lee, Y., López, D. E., Meloni, E. G., & Davis, M. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03775.1996 · Cited by 370 · see citing works
Self-citationMartinez, D., Narendran, R., Foltin, R. W., Slifstein, M., Hwang, D.-R., Broft, A., Huang, Y., Cooper, T. B., Fischman, M. W., Kleber, H. D., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.622 · Cited by 351 · see citing works
Long-lasting increase in the set point for cocaine self-administration after escalation in rats
Ahmed, S. H., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130051121 · Cited by 301 · see citing works
Ferrario, C. R., Gorny, G., Crombag, H. S., Li, Y., Kolb, B., & Robinson, T. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.046 · Cited by 283 · see citing works
Mantsch, J. R., Yuferov, V. P., Mathieu-Kia, A.-M., Ho, A., & Kreek, M. J. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1778-x · Cited by 214 · see citing works
Brain mechanisms of drug reward and euphoria.
Wise, R. A., & Bozarth, M. A. (1985) · PubMed · Cited by 206 · see citing works
Dissociation of Psychomotor Sensitization from Compulsive Cocaine Consumption
Ahmed, S. H., & Cador, M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300834 · Cited by 158 · see citing works
Malison, R. T., Best, S. E., van Dyck, C. H., McCance, E. F., Wallace, E. A., Laruelle, M. A., Baldwin, R. M., Seibyl, J. P., Price, L. H., Kosten, T. R., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.832 · Cited by 154 · see citing works
Mateo, Y., Läck, C. M., Morgan, D., Roberts, D. C. S., & Jones, S. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300687 · Cited by 139 · see citing works
Briand, L. A., Flagel, S. B., García-Fuster, M. J., Watson, S. J., Akil, H., Sarter, M. F., & Robinson, T. E. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.18 · Cited by 134 · see citing works
Ahmed, S. H., Lin, D. C.-H., Koob, G. F., & Parsons, L. H. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01833.x · Cited by 116 · see citing works
Knackstedt, L. A., & Kalivas, P. W. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.122861 · Cited by 114 · see citing works
The transition from controlled to compulsive drug use is associated with a loss of sensitization
Ben‐Shahar, O., Ahmed, S. H., Koob, G. F., & Ettenberg, A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.053 · Cited by 104 · see citing works
Acoustic startle, prepulse inhibition, and fear-potentiated startle measured in rhesus monkeys
Winslow, J. T., Parr, L. A., & Davis, M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01345-8 · Cited by 94 · see citing works
Self-citationGawin, F. H., & Ellinwood, E. H. (1989) · Annual Review of Medicine · doi:10.1146/annurev.me.40.020189.001053 · Cited by 94 · see citing works
Mutschler, N. H., & Miczek, K. A. (1998) · Psychopharmacology · doi:10.1007/s002130050584 · Cited by 90 · see citing works
Withdrawal from oral cocaine in rats: ultrasonic vocalizations and tactile startle
Miczek, K. A., & Barros, H. M. T. (1996) · Psychopharmacology · doi:10.1007/bf02246021 · Cited by 90 · see citing works
Davis, M., Svensson, T. H., & Aghajanian, G. K. (1975) · Psychopharmacology · doi:10.1007/bf00437607 · Cited by 85 · see citing works
Self-citationCocaine: Excitatory effects on sensorimotor reactivity measured with acoustic startle
Davis, M. T. (1985) · Psychopharmacology · doi:10.1007/bf00431680 · Cited by 78 · see citing works
Self-citationWithdrawal from IV cocaine "binges" in rats: ultrasonic distress calls and startle
Mutschler, N. H., & Miczek, K. A. (1998) · Psychopharmacology · doi:10.1007/s002130050497 · Cited by 77 · see citing works
Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake
Ahmed, S. H., & Koob, G. F. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1682-9 · Cited by 69 · see citing works
Changing patterns of cocaine use: Longitudinal observations, consequences, and treatment.
Siegel, R. K. (1984) · PsycEXTRA Dataset · doi:10.1037/e471372004-001 · Cited by 67 · see citing works
Czoty, P., Justice, J. B., & Howell, L. (2000) · Psychopharmacology · doi:10.1007/s002130050054 · Cited by 57 · see citing works
Self-citationDavis, M., Jv, C., Wh, W., & Kehne, J. H. (1986) · PubMed · Cited by 53 · see citing works
Self-citationThe role of 5HT1A receptors in the modulation of the acoustic startle reflex in rats
Nanry, K. P., & Tilson, H. A. (1989) · Psychopharmacology · doi:10.1007/bf00439556 · Cited by 47 · see citing works
Enhancement of the acoustic startle response in rats by the dopamine D 1 receptor agonist SKF 82958
Meloni, E. G., & Davis, M. (1999) · Psychopharmacology · doi:10.1007/s002130051020 · Cited by 41 · see citing works
Self-citationProlonged daily exposure to IV cocaine results in tolerance to its stimulant effects
Ben‐Shahar, O., Moscarello, J. M., Jacob, B., Roarty, M. P., & Ettenberg, A. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.09.013 · Cited by 36 · see citing works
Svensson, L., & Ahlenius, S. (1983) · Psychopharmacology · doi:10.1007/bf00427793 · Cited by 35 · see citing works
Davis, M., Commissaris, R. L., Cassella, J. V., Yang, S., Dember, L. M., & Harty, T. P. (1986) · Brain Research · doi:10.1016/0006-8993(86)90810-3 · Cited by 23 · see citing works
Self-citationDiminished Acoustic Startle in Chronic Cocaine Users
Efferen, T. R. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00089-5 · Cited by 22 · see citing works
Mansbach, R. S., Markou, A., & Patrick, G. A. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90552-5 · Cited by 18 · see citing works
Prepulse inhibition of the acoustic startle response in cocaine-withdrawn rats
Adams, J. U., Efferen, T. R., Duncan, E., et al. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00478-6 · Cited by 18 · see citing works
Cocaine-induced reinstatement during limited and extended drug access conditions in rhesus monkeys
Henry, P. K., & Howell, L. L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1485-8 · Cited by 12 · see citing works
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Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
- Authors
- Kirkland Henry, P., Davis, M., & Howell, L. L.
- Affiliations
- Emory University (US)
- Corresponding author
- Howell, Leonard L.
- ORCID
- Davis, Michael
- Venue
- Psychopharmacology
- Published
- 2009-04-14
- Volume
- 205
- Issue
- 2
- Pages
- 237-247
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC2796974
- OpenAlex
- W2123766280
- Cited by
- 34
- References
- 41
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service
- National Institute on Drug Abuse (R01DA018294, Z01DA000517, K02DA000517, DA016589, R01DA016589, DA018294)
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cocaine self-administration, extended access, restricted access, striatal dopamine, acoustic startle response, psychostimulant sensitivity, amphetamine, cocaine dependence, rhesus monkeys, in vivo microdialysis
- MeSH terms
- Acoustic Stimulation, Analysis of Variance, Animals, Behavior, Animal, Chromatography, High Pressure Liquid, Cocaine, Conditioning, Operant, Corpus Striatum, Dopamine, Dose-Response Relationship, Drug, Female, Homovanillic Acid, Macaca mulatta, Male, Phenols, Psychoacoustics, Reinforcement Schedule, Self Administration, Reflex, Startle, Styrenes, Time Factors, Microdialysis, Dopamine Uptake Inhibitors, Electrochemical Techniques
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