Effects of chronic cocaine abuse on postsynaptic dopamine receptors
Abstract
To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [18F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.
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Cocaine dependence is associated with a decrease in D2 receptor binding, a pattern that seems to persist after disease remission.
“There are multiple lines of evidence that cocaine dependence is associated with a decrease in D2 receptor binding [164-167], a pattern that seems to persist after disease remission [165].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [166]
Cocaine abuse is associated with decreased D2 receptor availability in the striatum compared with controls, first reported in 1990 and confirmed by later studies.
“The first report was in 1990, where a study showed that cocaine abuse was associated with a decrease in D2 receptor availability in the striatum compared to controls (Volkow et al, 1990), and has been followed by a series of studies confirming this observation”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Volkow et al, 1990
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- Authors
- Volkow, N. D., Fowler, J. S., Wolf, A. P., Schlyer, D. J., Shiue, C., Alpert, R., Dewey, S. L., Logan, J., Bendriem, B., & Christman, D. R.
- Affiliations
- Brookhaven National Laboratory (US)
- Venue
- American Journal of Psychiatry
- Published
- 1990-06-01
- Volume
- 147
- Issue
- 6
- Pages
- 719-724
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1506870724
- Cited by
- 421
- References
- 22
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 14 · 2022: 14 · 2021: 7 · 2020: 31 · 2019: 5 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 15
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- postsynaptic dopamine receptors, striatum, cocaine detoxification, drug-free interval, receptor recovery
- MeSH terms
- Adult, Basal Ganglia, Cocaine, Corpus Striatum, Fluorine Radioisotopes, Humans, Receptors, Dopamine, Spiperone, Tomography, Emission-Computed, Down-Regulation, Up-Regulation, Substance-Related Disorders
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