Cited by 421Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesSchizophrenia research and treatment

Effects of chronic cocaine abuse on postsynaptic dopamine receptors

Nora D. Volkow, Joanna S. Fowler, Alfred Peter Wolf, David J. Schlyer, Chyng‐Yann Shiue, Robert Alpert, Stephen L. Dewey, Jean Logan +2 more·1990·American Journal of Psychiatry

Abstract

To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [18F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.

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Registry

Crossref · 10.1176/ajp.147.6.719

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22 of 22 references verified0 citation errors · 0 not checkable

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Authors
Volkow, N. D., Fowler, J. S., Wolf, A. P., Schlyer, D. J., Shiue, C., Alpert, R., Dewey, S. L., Logan, J., Bendriem, B., & Christman, D. R.
Affiliations
Brookhaven National Laboratory (US)
Venue
American Journal of Psychiatry
Published
1990-06-01
Volume
147
Issue
6
Pages
719-724
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W1506870724
Cited by
421
References
22
Citations by year
2026: 3 · 2025: 3 · 2024: 8 · 2023: 14 · 2022: 14 · 2021: 7 · 2020: 31 · 2019: 5 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 15
FWCI
2.93
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
postsynaptic dopamine receptors, striatum, cocaine detoxification, drug-free interval, receptor recovery
MeSH terms
Adult, Basal Ganglia, Cocaine, Corpus Striatum, Fluorine Radioisotopes, Humans, Receptors, Dopamine, Spiperone, Tomography, Emission-Computed, Down-Regulation, Up-Regulation, Substance-Related Disorders

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