The DOI matches its Crossref record; 91 of the 92 references it cites were found in a registry or an index.
The 5-HT7 receptor and disorders of the nervous system: an overview
Open accessAbstract
Rationale The 5-HT(7) receptor is a more recently discovered G-protein-coupled receptor for serotonin. The functions and possible clinical relevance of this receptor are not yet fully understood.Objective The present paper reviews to what extent the use of animal models of human psychiatric and neurological disorders have implicated the 5-HT(7) receptor in such disorders. The studies have used a combination of pharmacological and genetic tools targeting the receptor to evaluate effects on behavior.Results Models of anxiety and schizophrenia have yielded mixed results with no clear role for the 5-HT(7) receptor described in these disorders. Some data are available for epilepsy, migraine, and pain but it is still very early to draw any definitive conclusions. There is a considerable amount of evidence supporting a role for the 5-HT(7) receptor in depression. Both blockade and inactivation of the receptor have resulted in an antidepressant-like profile in models of depression. Supporting evidence has also been obtained in sleep studies. Especially interesting are the augmented effects achieved by combining antidepressants and 5-HT(7) receptor antagonists. The antidepressant effect of amisulpride has been shown to most likely be mediated by the 5-HT(7) receptor.Conclusions The use of pharmacological and genetic tools in preclinical animal models strongly supports a role for the 5-HT(7) receptor in depression. Indirect evidence exists showing that 5-HT(7) receptor antagonism is clinically useful in the treatment of depression. Available data also indicate a possible involvement of the 5-HT(7) receptor in anxiety, epilepsy, pain, and schizophrenia.
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“the negative effects of chronic restraint stress on set-shifting were ameliorated by antagonizing the 5-HT7 receptor, which is implicated in the cognitive and behavioral manifestation of depression, with amisulpride (Hedlund 2009, Hedlund et al 2005, Leopoldo et al 2011, Nikiforuk & Popik 2013).”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Hedlund 2009
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Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · cited 1×
“The forced swim test and the tail suspension test are two of the most common behavioral models for evaluating the antidepressant potential of a drug or to evaluate the phenotype of transgenic animals with respect to depression (Cryan et al. 2002; Cryan and Holmes 2005).”
Geyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 1×
“Chronic unpredictable mild stress is a model that attempts to induce a depression-like state in laboratory animals (Willner et al. 1992).”
Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology
Shapiro, D. A., Renock, S. M., Arrington, E. G., Chiodo, L. A., Liu, L.-X., Sibley, D. R., Roth, B. L., & Mailman, R. B. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300203 · Cited by 982
Lovenberg, T. W., Baron, B. M., de Lecea, L., Miller, J. D., Prosser, R. A., Rea, M. A., Foye, P. E., Racke, M. M., Slone, A. L., Siegel, B. W., et al. (1993) · Neuron · doi:10.1016/0896-6273(93)90149-l · Cited by 691
Ruat, M., Traiffort, É., Leurs, R., Tardivel‐Lacombe, J., Díaz, J., Arrang, J., & Schwartz, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8547 · Cited by 630
Monsma, F. J., Shen, Y., Ward, R. P., Hamblin, M. W., & Sibley, D. R. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13616-x · Cited by 598
Choudhary, M. S., Craigo, S. C., Sibley, D. R., Roth, B. L., Monsma, F. J., Shen, Y., Uluer, A., & Meltzer, H. Y. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/74zp-ze10 · Cited by 592
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Sleep disturbance as transdiagnostic: Consideration of neurobiological mechanisms
Harvey, A. G., Murray, G., Chandler, R. A., & Soehner, A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.003 · Cited by 609
Sanchez, C., Asin, K. E., & Artigas, F. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.07.001 · Cited by 547
Millan, M. J., Fone, K. C. F., Steckler, T., & Horan, W. P. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.008 · Cited by 376
Loebel, A. D., Cucchiaro, J. B., Silva, R., Kroger, H., Hsu, J., Sarma, K., & Sachs, G. S. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070984 · Cited by 343
Suppes, T., Silva, R., Cucchiaro, J., Mao, Y., Targum, S., Streicher, C., Pikalov, A., & Loebel, A. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15060770 · Cited by 322
Metadata
- Authors
- Hedlund, P. B.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Hedlund, Peter B.
- Venue
- Psychopharmacology
- Published
- 2009-08-01
- Volume
- 206
- Issue
- 3
- Pages
- 345-354
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC2841472
- OpenAlex
- W1966819687
- Cited by
- 239
- References
- 92
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 13 · 2021: 2 · 2020: 11 · 2019: 7 · 2018: 13 · 2017: 19 · 2016: 11 · 2015: 25 · 2014: 19 · 2013: 23 · 2012: 31
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH73923, R01MH073923)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 5-HT7 receptor, serotonin, G protein-coupled receptors, depression, antidepressant-like effects, 5-HT7 receptor antagonists, amisulpride, anxiety, schizophrenia, epilepsy, migraine, pain, sleep, animal models of psychiatric disorders
- MeSH terms
- Animals, Antidepressive Agents, Disease Models, Animal, Humans, Nervous System Diseases, Receptors, Serotonin, Serotonin Antagonists
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