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A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue

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Yager, Lindsay M., Robinson, Terry E.·2013·Psychopharmacology

DOI 10.1007/s00213-012-2890-yPMC PMC3570662

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Abstract

Rationale Cues associated with rewards bias attention towards them and can motivate drug-seeking and drug-taking behavior. There is, however, considerable individual variation in the extent to which cues associated with rewards acquire motivational properties. For example, only in some rats does a localizable food cue become attractive, eliciting approach towards it, and "wanted", in the sense that it serves as an effective conditioned reinforcer.Objectives We asked whether the propensity of animals to attribute incentive salience to a food cue predicts the extent to which a classically conditioned cocaine cue acquires incentive motivational properties.Methods First, a Pavlovian conditioned approach procedure was used to identify rats prone to attribute incentive salience to a food cue. We then measured the extent to which a classically conditioned cocaine cue acquired two properties of an incentive stimulus: (1) the ability to elicit approach towards it, and (2) the ability to reinstate drug-seeking behavior, using an extinction-reinstatement procedure (i.e., to act as a conditioned reinforcer).Results We found that a classically conditioned cocaine cue became more attractive, in that it elicited greater approach toward it, and more desired, in that it supported more drug-seeking behavior under extinction conditions, in individuals prone to attribute incentive salience to a food cue.Conclusions We conclude that rats vary in their propensity to attribute incentive salience to both food and cocaine cues, and it is possible to predict, prior to any drug experience, in which rats a cocaine cue will acquire the strongest motivational control over behavior.

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Authors: Yager, L. M., & Robinson, T. E.
Affiliations: University of Michigan (US)
Corresponding author: Robinson, Terry E.
ORCID: Robinson, Terry E.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2012-10-24
Volume: 226
Issue: 2
Pages: 217-228
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-012-2890-y
PMC: PMC3570662
OpenAlex: W2083414260
Cited by: 123
References: 51
Citations by year: 2026: 3 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 18 · 2013: 9
FWCI: 5.14
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute for Health and Care Research
National Institutes of Health (4p01da031656-05)
National Institute on Drug Abuse (P01-DA-031656, F31DA030799, R37DA004294)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: cocaine cues, incentive salience, Pavlovian conditioned approach, conditioned reinforcer, drug-seeking behavior, individual differences, motivation, rats
MeSH terms: Animals, Behavior, Cocaine, Conditioning, Classical, Cues, Dose-Response Relationship, Drug, Food, Male, Motivation, Reward, Behavior, Addictive, Rats, Sprague-Dawley, Rats, Drug-Seeking Behavior

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A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue

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