Reinstatement of cocaine-reinforced responding in the rat

de Wit, Harriet; Stewart, Jane

doi:10.1007/bf00432175

Cited by 928Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Reinstatement of cocaine-reinforced responding in the rat

de Wit, Harriet, Stewart, Jane·1981·Psychopharmacology

DOI 10.1007/bf00432175

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Abstract

Non-contingent "priming" drug injections and conditioned stimuli associated with drug injections led to reinstatement of responding after a period of extinction. Rats implanted with intravenous catheters were trained to self-administer cocaine 1 mg/kg/injection), and then given daily test sessions consisting of a period of self-administration followed by extinction conditions. Test drug injections or conditioned stimuli were presented during extinction and the latency to the first response and the total number of responses following the treatment were measured. Cocaine injections of 0.5, 1.0, and 2.0 mg/kg restored responding during extinction, regardless of the duration of the extinction period (between 10 min and 180 min) since drug self-administration. Amphetamine, apomorphine, and morphine but not ethanol, heroin, or methohexital reinstated previously cocaine-reinforced responding. Amphetamine, cocaine, and morphine did not increase responding in animals trained to bar press only for food reinforcement, suggesting that the reinstatement effect is specific to drug-reinforced responses. The statement effect is specific to drug-reinforced responses. The final experiment showed that a tone that had been paired with drug infusions acquired a statistically significant tendency to facilitate responding when tested during extinction but this effect disappeared after the first test presentation of the tone.

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Reinstatement of drug-seeking after extinction is widely considered a valid model for drug-seeking and relapse.
“Reinstatement can occur as a result of stress, cues that predict the drug, or a dose of the drug itself, and is widely considered to be a valid model for drug-seeking and for relapse in general.”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as de Wit and Stewart 1981

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Authors: de Wit, H., & Stewart, J.
Affiliations: Concordia University (CA)
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1981-11
Volume: 75
Issue: 2
Pages: 134-143
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf00432175
OpenAlex: W2093757762
Cited by: 928
References: 42
Citations by year: 2026: 2 · 2025: 10 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 18 · 2020: 21 · 2019: 20 · 2018: 26 · 2017: 15 · 2016: 32 · 2015: 28 · 2014: 26 · 2013: 50 · 2012: 37
FWCI: 1.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Spectrum Research Repository (Concordia University) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: reinstatement, cocaine self-administration, extinction, conditioned stimulus, amphetamine, apomorphine, morphine, tone conditioning
MeSH terms: Animals, Cocaine, Conditioning, Classical, Extinction, Psychological, Humans, Male, Rats, Inbred Strains, Reinforcement, Psychology, Self Medication, Substance-Related Disorders, Rats

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Reinstatement of cocaine-reinforced responding in the rat

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