Cited by 123Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue

Open access

Yager, Lindsay M., Robinson, Terry E.·2013·Psychopharmacology

DOI 10.1007/s00213-012-2890-yPMC PMC3570662

Open this paper in CoChat — free account

Abstract

Rationale Cues associated with rewards bias attention towards them and can motivate drug-seeking and drug-taking behavior. There is, however, considerable individual variation in the extent to which cues associated with rewards acquire motivational properties. For example, only in some rats does a localizable food cue become attractive, eliciting approach towards it, and "wanted", in the sense that it serves as an effective conditioned reinforcer.Objectives We asked whether the propensity of animals to attribute incentive salience to a food cue predicts the extent to which a classically conditioned cocaine cue acquires incentive motivational properties.Methods First, a Pavlovian conditioned approach procedure was used to identify rats prone to attribute incentive salience to a food cue. We then measured the extent to which a classically conditioned cocaine cue acquired two properties of an incentive stimulus: (1) the ability to elicit approach towards it, and (2) the ability to reinstate drug-seeking behavior, using an extinction-reinstatement procedure (i.e., to act as a conditioned reinforcer).Results We found that a classically conditioned cocaine cue became more attractive, in that it elicited greater approach toward it, and more desired, in that it supported more drug-seeking behavior under extinction conditions, in individuals prone to attribute incentive salience to a food cue.Conclusions We conclude that rats vary in their propensity to attribute incentive salience to both food and cocaine cues, and it is possible to predict, prior to any drug experience, in which rats a cocaine cue will acquire the strongest motivational control over behavior.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00213-012-2890-y

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Self-citation
Linear Mixed Models for Longitudinal Data
Verbeke, G. (1997) · Lecture Notes in Statistics · doi:10.1007/978-1-4612-2294-1_3 · Cited by 3,506
Linear Mixed Models for Longitudinal Data
Molenberghs, G., & Verbeke, G. N. (2000) · Springer series in statistics · doi:10.1007/978-1-4419-0300-6 · Cited by 2,681
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
Perception and the Conditioned Reflex
Hay, J. C., & Sokolov, Y. N. (1966) · The American Journal of Psychology · doi:10.2307/1420734 · Cited by 2,123
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615
Pavlovian conditioning: it's not what you think it is
Rescorla, R. A. (1988) · American Psychologist · doi:10.1037/0003-066x.43.3.151 · Cited by 1,542
A selective role for dopamine in stimulus-reward learning
Flagel, S. B., Clark, J. J., Robinson, T. E., Mayo, L., Czuj, A., Willuhn, I., Akers, C. A., Clinton, S. M., Phillips, P. E. M., & Akil, H. (2011) · Nature · doi:10.1038/nature09588 · Cited by 1,026
Self-citation
Reinstatement of cocaine-reinforced responding in the rat
de Wit, H., & Stewart, J. (1981) · Psychopharmacology · doi:10.1007/bf00432175 · Cited by 928
Sign-tracking : the stimulus-reinforcer relation and directed action
Hearst, E. S., & Jenkins, H. M. (1974) · Medical Entomology and Zoology · Cited by 812

Show all 51 references

Research works printed but not linked: 1

National Research Council (US) Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research (2003) Guideline for the care and use of mammals in neuroscience and behavioral research. The National Academies Press, Washington, DC

Sorted by citations

Model-based and model-free Pavlovian reward learning: Revaluation, revision, and revelation
Dayan, P., & Berridge, K. C. (2014) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-014-0277-8 · Cited by 357
Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry
Castro, D. C., Cole, S. L., & Berridge, K. C. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00090 · Cited by 355
On the motivational properties of reward cues: Individual differences
Robinson, T. E., Yager, L. M., Cogan, E. S., & Saunders, B. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.040 · Cited by 261
Self-citation
Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior
Kawa, A. B., Bentzley, B. S., & Robinson, T. E. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4393-8 · Cited by 208
Self-citation
Understanding Addiction Using Animal Models
Kuhn, B. N., Kalivas, P. W., & Bobadilla, A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00262 · Cited by 174
Individual variation in resisting temptation: Implications for addiction
Saunders, B. T., & Robinson, T. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.008 · Cited by 177
Self-citation
Neurobiological basis of individual variation in stimulus-reward learning
Flagel, S. B., & Robinson, T. E. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.004 · Cited by 165
Self-citation
Cue-Evoked Cocaine "Craving": Role of Dopamine in the Accumbens Core
Saunders, B. T., Yager, L. M., & Robinson, T. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0450-13.2013 · Cited by 155
Self-citation
Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction
Cunningham, K. A., & Anastasio, N. C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.030 · Cited by 131
Role of cues and contexts on drug‐seeking behaviour
Perry, C. J., Zbukvic, I., Kim, J. H., & Lawrence, A. J. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12735 · Cited by 141
Rats that sign-track are resistant to Pavlovian but not instrumental extinction
Ahrens, A. M., Singer, B. F., Fitzpatrick, C. J., Morrow, J. D., & Robinson, T. E. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.055 · Cited by 112
Self-citation
Individual Variation in the Motivational and Neurobiological Effects of an Opioid Cue
Yager, L. M., Pitchers, K. K., Flagel, S. B., & Robinson, T. E. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.314 · Cited by 102
Self-citation
Individual variation in the propensity to attribute incentive salience to a food cue: Influence of sex
Pitchers, K. K., Flagel, S. B., O'Donnell, E. G., Woods, L. C. S., Sarter, M. F., & Robinson, T. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.036 · Cited by 95
Self-citation
The Form of a Conditioned Stimulus Can Influence the Degree to Which It Acquires Incentive Motivational Properties
Meyer, P., Cogan, E. S., & Robinson, T. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098163 · Cited by 94
Self-citation
Evidence for incentive salience sensitization as a pathway to alcohol use disorder
Cofresí, R. U., Bartholow, B. D., & Piasecki, T. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.009 · Cited by 94
Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics
Parker, C. C., Chen, H., Flagel, S. B., Geurts, A. M., Richards, J. B., Robinson, T. E., Woods, L. C. S., & Palmer, A. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.047 · Cited by 97
Self-citation
Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic effects on drug seeking
Barker, J. M., Taylor, J. R., Vries, T. J. D., & Peters, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.058 · Cited by 87
The neuroscience of cognitive-motivational styles: Sign- and goal-trackers as animal models.
Sarter, M. F., & Phillips, K. B. (2018) · Behavioral Neuroscience · doi:10.1037/bne0000226 · Cited by 83
Sign-tracking predicts increased choice of cocaine over food in rats
Tunstall, B. J., & Kearns, D. N. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.034 · Cited by 76
A Cocaine Context Renews Drug Seeking Preferentially in a Subset of Individuals
Saunders, B. T., O'Donnell, E. G., Aurbach, E. L., & Robinson, T. E. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.131 · Cited by 74
Self-citation
Diverse Roads to Relapse: A Discriminative Cue Signaling Cocaine Availability Is More Effective in Renewing Cocaine Seeking in Goal Trackers Than Sign Trackers and Depends on Basal Forebrain Cholinergic Activity
Pitchers, K. K., Phillips, K. B., Jones, J. L., Robinson, T. E., & Sarter, M. F. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0990-17.2017 · Cited by 72
Self-citation
A potential role for the paraventricular nucleus of the thalamus in mediating individual variation in Pavlovian conditioned responses
Haight, J. L., & Flagel, S. B. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00079 · Cited by 71
Under the influence: Effects of adolescent ethanol exposure and anxiety on motivation for uncertain gambling-like cues in male and female rats
Hellberg, S. N., Levit, J. D., & Robinson, M. J. F. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.036 · Cited by 70
Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies
Gileta, A. F., Fitzpatrick, C. J., Chitre, A. S., Pierre, C. L. S., Joyce, E. V., Maguire, R. J., McLeod, A. M., Gonzales, N. M., Williams, A. E., Morrow, J. D., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010234 · Cited by 81
Self-citation
Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior
Hellberg, S. N., Russell, T. I., & Robinson, M. J. F. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-00662-3 · Cited by 65
“In particular, specific individuals may bemore vulnerable to addictive spectrum disorders due to a naturally heightened sensitivity to reward cues (T. E. Robinson, Yager, Cogan, & Saunders, 2014b; Yager & Robinson, 2013).”
Implications of learning theory for developing programs to decrease overeating
Boutelle, K. N., & Bouton, M. E. (2015) · Appetite · doi:10.1016/j.appet.2015.05.013 · Cited by 63
Individual variability in behavioral flexibility predicts sign-tracking tendency
Nasser, H. M., Chen, Y.-W., Fiscella, K. A., & Calu, D. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00289 · Cited by 59
The Paraventricular Thalamus as a Critical Node of Motivated Behavior via the Hypothalamic-Thalamic-Striatal Circuit
Iglesias, A. G., & Flagel, S. B. (2021) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2021.706713 · Cited by 56
Neural Activity in the Ventral Pallidum Encodes Variation in the Incentive Value of a Reward Cue
Ahrens, A. M., Meyer, P., Ferguson, L. M., Robinson, T. E., & Aldridge, J. W. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0736-16.2016 · Cited by 57
Self-citation
Long‐lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign‐tracking
Fraser, K. M., & Janak, P. H. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13642 · Cited by 57
Motivational Processes Underlying Substance Abuse Disorder
Meyer, P., King, C. P., & Ferrario, C. R. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_391 · Cited by 59
Cocaine Self-Administration Experience Induces Pathological Phasic Accumbens Dopamine Signals and Abnormal Incentive Behaviors in Drug-Abstinent Rats
Saddoris, M. P., Wang, X., Sugam, J. A., & Carelli, R. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3468-15.2016 · Cited by 57
Neurofeedback of visual food cue reactivity: a potential avenue to alter incentive sensitization and craving
Ihssen, N., Sokunbi, M. O., Lawrence, A. D., Lawrence, N., & Linden, D. E. J. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9558-x · Cited by 59
The origins of individual differences in how learning is expressed in rats: A general-process perspective.
Patitucci, E., Nelson, A. J. D., Dwyer, D. M., & Honey, R. C. (2016) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000116 · Cited by 52
Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling
Spoelder, M., Tsutsui, K. T., Lesscher, H. M. B., Vanderschuren, L. J. M. J., & Clark, J. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.139 · Cited by 48
Compulsivity is measurable across distinct psychiatric symptom domains and is associated with familial risk and reward-related attentional capture
Albertella, L., Chamberlain, S. R., Pelley, M. E. L., Greenwood, L., Lee, R. S., Ouden, L. D., Segrave, R. A., Grant, J. E., & Yücel, M. (2019) · CNS Spectrums · doi:10.1017/s1092852919001330 · Cited by 54
Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats
Morrow, J. D., Saunders, B. T., Maren, S., & Robinson, T. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.002 · Cited by 44
Self-citation
Cocaine can generate a stronger conditioned reinforcer than food despite being a weaker primary reinforcer
Tunstall, B. J., & Kearns, D. N. (2014) · Addiction Biology · doi:10.1111/adb.12195 · Cited by 43
The attribution of incentive salience to Pavlovian alcohol cues: a shift from goal-tracking to sign-tracking
Srey, C. S., Maddux, J.-M. N., & Chaudhri, N. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00054 · Cited by 46
‘Hot’ vs. ‘cold’ behavioural‐cognitive styles: motivational‐dopaminergic vs. cognitive‐cholinergic processing of a Pavlovian cocaine cue in sign‐ and goal‐tracking rats
Pitchers, K. K., Kane, L. F., Kim, Y., Robinson, T. E., & Sarter, M. F. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13741 · Cited by 56
Self-citation
Reward-related attentional capture and cognitive inflexibility interact to determine greater severity of compulsivity-related problems
Albertella, L., Pelley, M. E. L., Chamberlain, S. R., Westbrook, R. F., Lee, R. S. C., Fontenelle, L. F., Grant, J. E., Segrave, R. A., McTavish, E., & Yücel, M. (2020) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2020.101580 · Cited by 46
Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function
Singer, B. F., Guptaroy, B., Austin, C. J., Wohl, I., Lovic, V., Seiler, J. L., Vaughan, R. A., Gnegy, M. E., Robinson, T. E., & Aragona, B. J. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13134 · Cited by 43
Self-citation
From sign-tracking to attentional bias: Implications for gambling and substance use disorders
Anselme, P., & Robinson, M. J. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109861 · Cited by 48
Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors
Pitts, E. G., Taylor, J. R., & Gourley, S. L. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.021 · Cited by 41
Cocaine-seeking behavior in a genetic model of attention-deficit/hyperactivity disorder following adolescent methylphenidate or atomoxetine treatments
Jordan, C. J., Harvey, R. C., Baskin, B. B., Dwoskin, L. P., & Kantak, K. M. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.04.020 · Cited by 38
Effects of Limited and Extended Pavlovian Training on Devaluation Sensitivity of Sign- and Goal-Tracking Rats
Keefer, S. E., Bacharach, S. Z., Kochli, D. E., Chabot, J. M., & Calu, D. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00003 · Cited by 40
Individual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue
Villaruel, F. R., & Chaudhri, N. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00238 · Cited by 35
Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases
Cherian, A. K., Kucinski, A. J., Pitchers, K. K., Yegla, B., Parikh, V., Kim, Y., Valuskova, P., Gurnani, S. D., Lindsley, C. W., Blakely, R., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3499-16.2017 · Cited by 36
Individual variation in the motivational properties of a nicotine cue: sign-trackers vs. goal-trackers
Yager, L. M., & Robinson, T. E. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3962-6 · Cited by 34
Self-citation
Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
King, C. P., Tripi, J. A., Netzley, A. H., Horvath, A. P., Lamparelli, A. C., Holl, K. L., Chitre, A. S., Polesskaya, O., Ishiwari, K., Woods, L. C. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80798-w · Cited by 32
Self-citation
The hot ‘n’ cold of cue-induced drug relapsePreprint
Pitchers, K. K., Sarter, M. F., & Robinson, T. E. (2018) · Learning & Memory · doi:10.1101/lm.046995.117 · Cited by 36
Self-citation
Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration
Pohořalá, V., Enkel, T., Bartsch, D., Spanagel, R., & Bernardi, R. E. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05858-z · Cited by 29
Transient inactivation of the paraventricular nucleus of the thalamus enhances cue-induced reinstatement in goal-trackers, but not sign-trackers
Kuhn, B. N., Klumpner, M. S., Covelo, I. R., Campus, P., & Flagel, S. B. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4816-1 · Cited by 35
The sensory features of a food cue influence its ability to act as an incentive stimulus and evoke dopamine release in the nucleus accumbens corePreprint
Singer, B. F., Bryan, M. A., Popov, P., Scarff, R., Carter, C., Wright, E., Aragona, B. J., & Robinson, T. E. (2016) · Learning & Memory · doi:10.1101/lm.043026.116 · Cited by 30
Self-citation
Skewed by Cues? The Motivational Role of Audiovisual Stimuli in Modelling Substance Use and Gambling Disorders
Barrus, M. M., Cherkasova, M. V., & Winstanley, C. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_393 · Cited by 30
Pavlovian Conditioned Approach Training in Rats
Fitzpatrick, C. J., & Morrow, J. D. (2016) · Journal of Visualized Experiments · doi:10.3791/53580 · Cited by 29
Neurons of the Ventral Tegmental Area Encode Individual Differences in Motivational “Wanting” for Reward Cues
Ferguson, L. M., Ahrens, A. M., Longyear, L. G., & Aldridge, J. W. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2947-19.2020 · Cited by 31
Appetitive behavioral traits and stimulus intensity influence maintenance of conditioned fear
Olshavsky, M. E., Jones, C. E., Lee, H. J., & Monfils, M. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00179 · Cited by 29
Dynamic Encoding of Incentive Salience in the Ventral Pallidum: Dependence on the Form of the Reward Cue
Ahrens, A. M., Ferguson, L. M., Robinson, T. E., & Aldridge, J. W. (2018) · eNeuro · doi:10.1523/eneuro.0328-17.2018 · Cited by 25
Self-citation
Individual differences in voluntary alcohol intake in rats: relationship with impulsivity, decision making and Pavlovian conditioned approach
Spoelder, M., Flores-Dourojeanni, J. P., de Git, K. C. G., Baars, A. M., Lesscher, H. M. B., & Vanderschuren, L. J. M. J. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4617-6 · Cited by 30
The ability for cocaine and cocaine-associated cues to compete for attention
Pitchers, K. K., Wood, T. R., Skrzynski, C. J., Robinson, T. E., & Sarter, M. F. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.024 · Cited by 28
Self-citation
Inhibition of Dopamine Neurons Prevents Incentive Value Encoding of a Reward Cue: With Revelations from Deep Phenotyping
Iglesias, A. G., Chiu, A. S., Wong, J. W. H., Campus, P., Li, F. R., Liu, Z., Bhatti, J. K., Patel, S. A., Deisseroth, K. A., Akil, H., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0848-23.2023 · Cited by 32
Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation
Ahrens, A. M., & Ahmed, O. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.007 · Cited by 25
Early life adversity potentiates expression of addiction-related traits
Hynes, T. J., Thomas, C. S., Zumbusch, A. S., Samson, A., Petriman, I., Mrdja, U., Orr, A., Cutts, E., Ruzindana, B. G., Hazari, A., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.005 · Cited by 28
Individual differences in food cue responsivity are associated with acute and repeated cocaine-induced vocalizations, but not cue-induced vocalizations
Tripi, J. A., Dent, M. L., & Meyer, P. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4476-6 · Cited by 23
Sign tracking predicts suboptimal behavior in a rodent gambling task
Swintosky, M., Brennan, J. T., Koziel, C., Paulus, J. P., & Morrison, S. E. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05887-8 · Cited by 22
The synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline increases alcohol self-administration and alters basolateral amygdala response to alcohol in rats
Makhijani, V. H., Franklin, J. P., Voorhies, K. J. V., Fortino, B., & Besheer, J. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05659-w · Cited by 22
Sign tracking predicts cue-induced but not drug-primed reinstatement to methamphetamine seeking in rats: Effects of oxytocin treatment
Everett, N. A., Carey, H., Cornish, J. L., & Baracz, S. J. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120954052 · Cited by 21
Addiction vulnerability trait impacts complex movement control: Evidence from sign-trackers
Kucinski, A. J., Lustig, C., & Sarter, M. F. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.045 · Cited by 20
Pavlovian conditioned approach, extinction, and spontaneous recovery to an audiovisual cue paired with an intravenous heroin infusion
Peters, J., & Vries, T. J. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3258-7 · Cited by 19
Addiction vulnerability and the processing of significant cues: Sign-, but not goal-, tracker perceptual sensitivity relies on cue salience.
Phillips, K. B., & Sarter, M. F. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000353 · Cited by 25
Basal forebrain chemogenetic inhibition disrupts the superior complex movement control of goal-tracking rats.
Kucinski, A. J., Kim, Y., & Sarter, M. F. (2019) · Behavioral Neuroscience · doi:10.1037/bne0000290 · Cited by 18
Risk-promoting effects of reward-paired cues in human sign- and goal-trackers
Cherkasova, M. V., Clark, L., Barton, J. J. S., Stoessl, A. J., & Winstanley, C. A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114865 · Cited by 23
Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in “relapse prone” male rats
Kuhn, B. N., Campus, P., Klumpner, M. S., Chang, S. E., Iglesias, A. G., & Flagel, S. B. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05894-9 · Cited by 18
From skinner box to daily life: Sign-tracker phenotype co-segregates with impulsivity, compulsivity, and addiction tendencies in humans
Schettino, M., Ceccarelli, I., Tarvainen, M. P., Martelli, M., Orsini, C., & Ottaviani, C. (2022) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-022-01014-y · Cited by 20
Stress-free automatic sleep deprivation using air puffs
Gross, B. A., Vanderheyden, W. M., Urpa, L., Davis, D. E., Fitzpatrick, C. J., Prabhu, K. A., & Poe, G. R. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.05.010 · Cited by 15
Investigating discriminative stimulus modulation of opioid seeking after conflict-induced abstinence in sign- and goal-tracking rats
Martin, D. A., Keefer, S. E., & Calu, D. J. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06204-7 · Cited by 14
Hierarchical cue control of cocaine seeking in the face of cost
Collins, V. L., Bornhoft, K. N., Wolff, A. R., Sinha, S., & Saunders, B. T. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06218-1 · Cited by 13
Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studiesPreprint
Gileta, A. F., Fitzpatrick, C. J., Chitre, A. S., Pierre, C. L. S., Joyce, E. V., Maguire, R. J., McLeod, A. M., Gonzales, N. M., Williams, A. E., Morrow, J. D., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/412924 · Cited by 14
Self-citation
Pavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive behavior
Harb, M. R., & Almeida, O. F. X. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.28 · Cited by 13
Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD
Eagle, D. M., Schepisi, C., Chugh, S., Desai, S., Han, S. Y. S., Huang, T., Lee, J. J., Sobala, C., Ye, W., Milton, A. L., et al. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05636-3 · Cited by 12
Checking responses of goal- and sign-trackers are differentially affected by threat in a rodent analog of obsessive–compulsive disorderPreprint
Vousden, G. H., Paulcan, S., Robbins, T. W., Eagle, D. M., & Milton, A. L. (2020) · Learning & Memory · doi:10.1101/lm.050260.119 · Cited by 12
Translations in Stimulus–Stimulus Pairing: Autoshaping of Learner Vocalizations
da Silva, S. P., & Williams, A. M. (2019) · Perspectives on Behavior Science · doi:10.1007/s40614-019-00228-9 · Cited by 11
MAM (E17) rodent developmental model of neuropsychiatric disease: disruptions in learning and dysregulation of nucleus accumbens dopamine release, but spared executive function
Howe, W., Tierney, P. L., Young, D., Oomen, C., & Kozak, R. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3955-5 · Cited by 10
The attribution of incentive salience to an appetitive conditioned cue is not affected by knockout of the serotonin transporter in rats
Nonkes, L. J. P., van de Vondervoort, I. I. G. M., & Homberg, J. R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.017 · Cited by 9
Sign‐trackers have elevated myo‐inositol in the nucleus accumbens and ventral hippocampus following Pavlovian conditioned approach
Fitzpatrick, C. J., Perrine, S. A., Ghoddoussi, F., Galloway, M. P., & Morrow, J. D. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13524 · Cited by 9
Resting-state brain activation patterns and network topology distinguish human sign and goal trackers
Schettino, M., Mauti, M., Parrillo, C., Ceccarelli, I., Giove, F., Napolitano, A., Ottaviani, C., Martelli, M., & Orsini, C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03162-w · Cited by 12
Mesocorticolimbic system reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: A pilot fMRI study
Cofresí, R. U., Upton, S., Brown, A. A., Piasecki, T. M., Bartholow, B. D., & Froeliger, B. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100156 · Cited by 6
Male Goal-Tracker and Sign-Tracker Rats Do Not Differ in Neuroendocrine or Behavioral Measures of Stress Reactivity
Lopez, S. A., Mubarak, E., Yang, C., Parsegian, A., Klumpner, M. S., Campus, P., & Flagel, S. B. (2021) · eNeuro · doi:10.1523/eneuro.0384-20.2021 · Cited by 7
Serotonin neurobiology in cocaine use disorder
Cunningham, K. A., Howell, L. L., & Anastasio, N. C. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00040-2 · Cited by 6
Comment on Pohorala et al.: Sign-tracking as a predictor of addiction vulnerability
Flagel, S. B., Robinson, T. E., & Sarter, M. F. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05927-3 · Cited by 6
Self-citation
Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addictionPreprint
Saddoris, M. P., Siletti, K. A., Stansfield, K. J., & Bercum, F. M. (2018) · Learning & Memory · doi:10.1101/lm.047019.117 · Cited by 8
Adrenergic manipulation inhibits pavlovian conditioned approach behaviors
Pasquariello, K. Z., Han, M., Unal, C., & Meyer, P. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.037 · Cited by 4
Propensity for risky choices despite lower cue reactivity in adolescent rats
Zeng, S., McLaughlin, E. F. B., Ramesh, A., & Morrison, S. E. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1297293 · Cited by 6
Sensitization to apomorphine in pigeons
Delius, J. D., Acerbo, M. J., Krug, I., Lee, J., & Leydel, R. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000087 · Cited by 5
Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats
Algallal, H., Laplante, I., Casale, D., Najafipashaki, S., Pomerleau, A., Paquette, T., & Samaha, A. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06985-7 · Cited by 3
Sex‐associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse
Hakus, A., Foo, J. C., Casquero‐Veiga, M., Gül, A. Z., Hintz, F., Rivalan, M., Winter, Y., Priller, J., Hadar, R., & Winter, C. (2025) · Addiction Biology · doi:10.1111/adb.70009 · Cited by 5
Fentanyl reinstatement to discriminative cues after conflict in sign- and goal-tracking ratsPreprint
Martin, D. A., Keefer, S. E., & Calu, D. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.10.479913 · Cited by 2
Individual Differences in Reward Sensitivity in Nonhuman Animals
Pierce-Messick, Z. J., & Corbit, L. H. (2025) · Springer eBooks · doi:10.1007/978-3-031-77967-1_7 · Cited by 1
Conditioning‐ and reward‐related dendritic and presynaptic plasticity of nucleus accumbens neurons in male and female sign‐tracker rats
Colom, M., Kraev, I., Stramek, A. K., Loza, I. B., Rostron, C. L., Heath, C. J., Dommett, E. J., & Singer, B. F. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16513 · Cited by 2

Authors: Yager, L. M., & Robinson, T. E.
Affiliations: University of Michigan (US)
Corresponding author: Robinson, Terry E.
ORCID: Robinson, Terry E.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2012-10-24
Volume: 226
Issue: 2
Pages: 217-228
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-012-2890-y
PMC: PMC3570662
OpenAlex: W2083414260
Cited by: 123
References: 51
Citations by year: 2026: 3 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 18 · 2013: 9
FWCI: 5.14
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute for Health and Care Research
National Institutes of Health (4p01da031656-05)
National Institute on Drug Abuse (P01-DA-031656, F31DA030799, R37DA004294)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: cocaine cues, incentive salience, Pavlovian conditioned approach, conditioned reinforcer, drug-seeking behavior, individual differences, motivation, rats
MeSH terms: Animals, Behavior, Cocaine, Conditioning, Classical, Cues, Dose-Response Relationship, Drug, Food, Male, Motivation, Reward, Behavior, Addictive, Rats, Sprague-Dawley, Rats, Drug-Seeking Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks