Cited by 197Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

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Glutamatergic targets for new alcohol medications

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Holmes, Andrew, Spanagel, Rainer, Krystal, John H.·2013·Psychopharmacology

DOI 10.1007/s00213-013-3226-2PMC PMC3811052

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Abstract

Rationale An increasingly compelling literature points to a major role for the glutamate system in mediating the effects of alcohol on behavior and the pathophysiology of alcoholism. Preclinical studies indicate that glutamate signaling mediates certain aspects of ethanol's intoxicating and rewarding effects, and undergoes adaptations following chronic alcohol exposure that may contribute to the withdrawal, craving and compulsive drug-seeking that drive alcohol abuse and alcoholism.Objectives We discuss the potential for targeting the glutamate system as a novel pharmacotherapeutic approach to treating alcohol use disorders, focusing on five major components of the glutamate system: the N-methyl-D-aspartate (NMDA) receptor and specific NMDA subunits, the glycineB site on the NMDA receptors (NMDAR), L-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid ionotropic (AMPA) and kainate (KAR) receptors, metabotropic receptors (mGluR), and glutamate transporters.Results Chronic alcohol abuse produces a hyperglutamatergic state, characterized by elevated extracellular glutamate and altered glutamate receptors and transporters. Pharmacologically manipulating glutamatergic neurotransmission alters alcohol-related behaviors including intoxication, withdrawal, and alcohol-seeking, in rodents and human subjects. Blocking NMDA and AMPA receptors reduces alcohol consumption in rodents, but side-effects may limit this as a therapeutic approach. Selectively targeting NMDA and AMPA receptor subunits (e.g., GluN2B, GluA3), or the NMDAR glycineB site offers an alternative approach. Blocking mGluR5 potently affects various alcohol-related behaviors in rodents, and mGluR2/3 agonism also suppresses alcohol consumption. Finally, glutamate transporter upregulation may mitigate behavioral and neurotoxic sequelae of excess glutamate caused by alcohol.Conclusions Despite the many challenges that remain, targeting the glutamate system offers genuine promise for developing new treatments for alcoholism.

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A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805
Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870
Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence: The COMBINE Study: A Randomized Controlled Trial
Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2003 · Cited by 1,930
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,448
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Patil, S. T., Zhang, L., Martenyi, F., Lowe, S. L., Jackson, K. A., Andreev, B. V., Avedisova, A. S., Bardenstein, L. M., Gurovich, I. Y., Morozova, M. A., et al. (2007) · Nature Medicine · doi:10.1038/nm1632 · Cited by 1,040
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917
Drug Addiction as a Pathology of Staged Neuroplasticity
Kalivas, P. W., & O’Brien, C. P. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301564 · Cited by 761
Oral topiramate for treatment of alcohol dependence: A randomised controlled trial
Johnson, B. A., Ait-Daoud, N., Bowden, C. L., DiClemente, C. C., Roache, J. D., Lawson, K., Javors, M. A., & Ma, J. Z. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13370-3 · Cited by 743
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
Schoepp, D. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29296-x · Cited by 693
Efficacy and Tolerability of Long-Acting Injectable Naltrexone for Alcohol Dependence
Garbutt, J. C., Kranzler, H. R., O’Malley, S. S., Gastfriend, D. R., Pettinati, H. M., Silverman, B. L., Loewy, J. W., Ehrich, E. W., & for the Vivitrex Study Group (2005) · JAMA · doi:10.1001/jama.293.13.1617 · Cited by 632
Naltrexone in the Treatment of Alcohol Dependence
Krystal, J. H., Cramer, J. A., Krol, W. F., Kirk, G. F., & Rosenheck, R. A. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011127 · Cited by 618
Self-citation
Mechanisms of Neurodegeneration and Regeneration in Alcoholism
Crews, F. T., & Nixon, K. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn079 · Cited by 596
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
Spanagel, R., Pendyala, G., Abarca, C., Zghoul, T., Sanchis-Segura, C., Magnone, M. C., Lascorz, J., Depner, M., Holzberg, D., Soyka, M., et al. (2005) · Nature Medicine · doi:10.1038/nm1163 · Cited by 594
Self-citation
Neuropharmacology of alcohol addiction
Vengeliene, V., Bilbao, A., Molander, A., & Spanagel, R. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.30 · Cited by 585
Self-citation
Topiramate for Treating Alcohol Dependence<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Johnson, B. A. (2007) · JAMA · doi:10.1001/jama.298.14.1641 · Cited by 542
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.256.11.1449 · Cited by 541
Neurocircuitry in alcoholism: a substrate of disruption and repair
Sullivan, E. V., & Adolf Pfefferbaum, A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2267-6 · Cited by 503
Glutamatergic substrates of drug addiction and alcoholism
Gass, J. T., & Olive, M. F. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.039 · Cited by 502
Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful?
Maisel, N. C., Blodgett, J. C., Wilbourne, P. L., Humphreys, K., & Finney, J. W. (2013) · Addiction · doi:10.1111/j.1360-0443.2012.04054.x · Cited by 470
NMDA-dependent modulation of CA1 local circuit inhibition
Grunze, H., Rainnie, D., Hasselmo, M., Barkai, E., Hearn, E., McCarley, R., & Greene, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02034.1996 · Cited by 467
An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?
Thomson, A. M., West, D. C., & Lodge, D. (1985) · Nature · doi:10.1038/313479a0 · Cited by 458
Pharmacological Treatment of Alcohol Dependence: A Review of the Evidence
Garbutt, J. C., West, S. L., Carey, T. S., Lohr, K. N., & Crews, F. T. (1999) · JAMA · doi:10.1001/jama.281.14.1318 · Cited by 444 · cited 1×
“However, despite the promise of early clinical data (Garbutt et al. 1999), the long-term efficacy of naltrexone has proven modest (Fuller et al.”
Background
Ethanol withdrawal seizures and the NMDA receptor complex
Grant, K. A., Valverius, P., Hudspith, M. J., & Tabakoff, B. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90022-x · Cited by 432
Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.1986.03380110055026 · Cited by 431
Glutamate-based antidepressants: 20 years on
Skolnick, P., Popik, P., & Trullás, R. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.002 · Cited by 386
The Role of Glutamatergic Neurotransmission in the Pathophysiology of Alcoholism
Tsai, G. E., & Coyle, J. T. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.173 · Cited by 382
The pharmacological treatment of alcohol dependence.
Swift, R. M. (1997) · PubMed · Cited by 372
Disulfiram Treatment of Alcoholism
Chick, J., Gough, K. A., Falkowski, W., Kershaw, P. W., Hore, B. D., Mehta, B. M., Ritson, B., Ropner, R., & Torley, D. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.1.84 · Cited by 369
Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-d-aspartate receptor
Clements, J. D., & Westbrook, G. L. (1991) · Neuron · doi:10.1016/0896-6273(91)90373-8 · Cited by 340
Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning
Brigman, J. L., Wright, T., Talani, G., Prasad-Mulcare, S., Jinde, S., Seabold, G. K., Mathur, P., Davis, M. I., Bock, R., Gustin, R. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0640-10.2010 · Cited by 339
Self-citation
N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability
Krystal, J. H., Petrakis, I. L., Mason, G. F., Trevisan, L. A., & D’Souza, D. C. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00054-8 · Cited by 318
Self-citation
Acute and Chronic Ethanol Alter Glutamatergic Transmission in Rat Central Amygdala: an In Vitro and In Vivo Analysis
Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., & Siggins, G. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5077-03.2004 · Cited by 312
Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes
Fadda, E., Danysz, W., Wroblewski, J. T., & Costa, E. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90015-9 · Cited by 259
Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens
Rassnick, S., Pulvirenti, L., & Koob, G. F. (1992) · Psychopharmacology · doi:10.1007/bf02245485 · Cited by 257
A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression
Zarate, C. A., Mathews, D., Ibrahim, L., Chaves, J. F., Marquardt, C., Ukoh, I., Jolkovsky, L., Brutsche, N. E., Smith, M. A., & Luckenbaugh, D. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.019 · Cited by 255
mGluR5 Antagonist MPEP Reduces Ethanol-Seeking and Relapse Behavior
Bäckström, P., Bachteler, D., Koch, S., Hyytiä, P., & Spanagel, R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300381 · Cited by 249
Self-citation
Chronic Alcohol Exposure Alters Behavioral and Synaptic Plasticity of the Rodent Prefrontal Cortex
Kroener, S., Mulholland, P. J., New, N., Gass, J. T., Becker, H. C., & Chandler, L. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037541 · Cited by 248
Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach
Neyton, J., & Paoletti, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5242-05.2006 · Cited by 245
Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum
Rossetti, Z. L., & Carboni, S. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00344-k · Cited by 237
Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability
Mozhui, K., Karlsson, R.-M., Kash, T. L., Ihne, J., Norcross, M., Patel, S., Farrell, M. R., Hill, E. E., Graybeal, C., Martin, K. P., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5017-09.2010 · Cited by 226
Self-citation
Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding
Holmes, A., Fitzgerald, P. J., MacPherson, K. P., DeBrouse, L., Colacicco, G., Flynn, S. M., Masneuf, S., Pleil, K. E., Li, C., Marcinkiewcz, C. A., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3204 · Cited by 218
Self-citation
Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: The role of patient motivation
MASON, B., GOODMAN, A., Chabac, S., & Lehert, P. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.002 · Cited by 212
Genetic Inactivation of the NMDA Receptor NR2A Subunit has Anxiolytic- and Antidepressant-Like Effects in Mice
Boyce‐Rustay, J. M., & Holmes, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301039 · Cited by 212
Self-citation
Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?
Wolf, M. E., & Tseng, K. Y. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00072 · Cited by 206
Translational Magnetic Resonance Spectroscopy Reveals Excessive Central Glutamate Levels During Alcohol Withdrawal in Humans and Rats
Hermann, D., Weber‐Fahr, W., Sartorius, A., Hoerst, M., Frischknecht, U., Tunc‐Skarka, N., Perreau‐Lenz, S., Hansson, A. C., Krumm, B., Kiefer, F., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.034 · Cited by 203
Self-citation
Modulation of N‐methyl‐D‐aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.
Vyklický, L., Benveniste, M., & Mayer, M. L. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018214 · Cited by 197
Increased Glutamatergic Neurotransmission and Oxidative Stress After Alcohol Withdrawal
Tsai, G. E., Ragan, P. W., Chang, R., Chen, S. K., Linnoila, V. M. I., & COYLE, J. T. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.726 · Cited by 194
Activation of Group II Metabotropic Glutamate Receptors Attenuates Both Stress and Cue-Induced Ethanol-Seeking and Modulates c-fos Expression in the Hippocampus and Amygdala
Zhao, Y., Dayas, C. V., Aujla, H., Baptista, M. A. S., Martin-Fardon, R., & Weiss, F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2384-06.2006 · Cited by 192
Rescue of Infralimbic mGluR2Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence
Meinhardt, M. W., Hansson, A. C., Perreau‐Lenz, S., Bauder-Wenz, C., Stählin, O., Heilig, M. A., Harper, C. G., Drescher, K. U., Spanagel, R., & Sommer, W. H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4062-12.2013 · Cited by 181
Self-citation
Ionotropic and Metabotropic Glutamate Receptor Antagonism Attenuates Cue-Induced Cocaine Seeking
Bäckström, P., & Hyytiä, P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300845 · Cited by 177
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse
Barak, S., Liu, F., Hamida, S. B., Yowell, Q. V., Neasta, J., Kharazia, V., Janak, P. H., & Ron, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3439 · Cited by 172
Chronic Ethanol and Withdrawal Differentially Modulate Pre- and Postsynaptic Function at Glutamatergic Synapses in Rat Basolateral Amygdala
Läck, A. K., Diaz, M. R., Chappell, A. M., DuBois, D. W., & McCool, B. A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00189.2007 · Cited by 167
Chronic Ethanol Induces Synaptic But Not Extrasynaptic Targeting of NMDA Receptors
Carpenter‐Hyland, E. P., Woodward, J. J., & Chandler, L. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-04.2004 · Cited by 166
Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics
Krystal, J. H., Petrakis, I. L., Webb, E., Cooney, N. L., Karper, L. P., Namanworth, S. N., Stetson, P. L., Trevisan, L. A., & Charney, D. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.4.354 · Cited by 166
Self-citation
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
Fuller, R. K., Branchey, L., Brightwell, D. R., Derman, R., Emrick, C. D., Iber, F. L., James, K. E., Lacoursiere, R. B., Lee, K. K., & Lowenstam, I. (1986) · PubMed · Cited by 166
GluN2B in corticostriatal circuits governs choice learning and choice shifting
Brigman, J. L., Daut, R. A., Wright, T., Gunduz‐Cinar, O., Graybeal, C., Davis, M. I., Jiang, Z., Saksida, L. M., Jinde, S., Pease, M. W., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3457 · Cited by 162
Self-citation
The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats
Schroeder, J. P., Overstreet, D. H., & Hodge, C. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2175-9 · Cited by 161
Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats
Bäckström, P., & Hyytiä, P. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0753-8 · Cited by 157
Oral Topiramate Reduces the Consequences of Drinking and Improves theQuality of Life of Alcohol-Dependent Individuals
Johnson, B. A., Ait‐Daoud, N., Akhtar, F. Z., & Ma, J. Z. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.905 · Cited by 156
The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice
Hodge, C. W., Miles, M. F., Sharko, A. C., Stevenson, R. A., Hillmann, J. R., Lepoutre, V., Besheer, J., & Schroeder, J. P. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0217-y · Cited by 153
Binge Drinking Upregulates Accumbens mGluR5-Homer2-PI3K Signaling: Functional Implications for Alcoholism
Cozzoli, D. K., Goulding, S. P., Zhang, P. W., Xiao, B., Hu, J. H., Ary, A. W., Obara, I., Rahn, A., Abou-Ziab, H., Tyrrel, B., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5900-08.2009 · Cited by 149
Comparing topiramate with naltrexone in the treatment of alcohol dependence
Baltieri, D. A., Daró, F. R., Ribeiro, P. L., & De Andrade, A. G. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02355.x · Cited by 145
Effect of Acamprosate on Magnetic Resonance Spectroscopy Measures of Central Glutamate in Detoxified Alcohol-Dependent Individuals: A Randomized Controlled Experimental Medicine Study
Umhau, J. C., Momenan, R., Schwandt, M. L., Singley, E., Lifshitz, M., Doty, L., Adams, L. J., Vengeliene, V., Spanagel, R., Zhang, Y., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.125 · Cited by 144
Self-citation
Involvement of the AMPA Receptor GluR-C Subunit in Alcohol-Seeking Behavior and Relapse
Sanchis‐Segura, C., Borchardt, T., Vengeliene, V., Zghoul, T., Bachteler, D., Gass, P., Sprengel, R., & Spanagel, R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4237-05.2006 · Cited by 143
Self-citation
Altered NMDA Glutamate Receptor Antagonist Response in Individuals With a Family Vulnerability to Alcoholism
Petrakis, I. L., Limoncelli, D., Gueorguieva, R. V., Jatlow, P. L., Boutros, N. N., Trevisan, L. A., Gelernter, J. E., & Krystal, J. H. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1776 · Cited by 143
Self-citation
Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG
Bäckström, P., & Hyytiä, P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.051 · Cited by 141
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect
Vengeliene, V., Bachteler, D., Danysz, W., & Spanagel, R. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.002 · Cited by 141
Self-citation
Ceftriaxone, a Beta-Lactam Antibiotic, Reduces Ethanol Consumption in Alcohol-Preferring Rats
Sari, Y., Sakai, M., Weedman, J. M., Rebec, G. V., & Bell, R. L. (2011) · Alcohol and Alcoholism · doi:10.1093/alcalc/agr023 · Cited by 137
Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders
Neasta, J., Hamida, S. B., Yowell, Q. V., Carnicella, S., & Dorit Ron, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005554107 · Cited by 136
Regulation of NMDA receptors by ethanol
Kumari, M., & Ticku, M. K. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8391-7_5 · Cited by 135
Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers
Breese, C. R., Freedman, R., & Leonard, S. S. (1995) · Brain Research · doi:10.1016/0006-8993(94)01384-t · Cited by 134
Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists.
Grant, K. A., & Colombo, G. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10137-7 · Cited by 134
Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens
Moghaddam, B., & Bolinao, M. L. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90299-2 · Cited by 131
Antiglutamatergic Strategies for Ethanol Detoxification: Comparison With Placebo and Diazepam
Krupitsky, E. M., Rudenko, A. A., Burakov, A. M., Slavina, T. Y., Grinenko, A. Y., Pittman, B. P., Gueorguieva, R. V., Petrakis, I. L., Zvartau, E. E., & Krystal, J. H. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00344.x · Cited by 130
Self-citation
Voluntary Ethanol Intake Enhances Excitatory Synaptic Strength in the Ventral Tegmental Area
Stuber, G. D., Hopf, F. W., Hahn, J., Cho, S. L., Guillory, A. M., & Bonci, A. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00749.x · Cited by 130
The mGluR5 Antagonist 6-Methyl-2-(phenylethynyl)pyridine Decreases Ethanol Consumption via a Protein Kinase Cϵ-Dependent Mechanism
Olive, M. F., McGeehan, A., Kinder, J. R., McMahon, T., Hodge, C. W., Janak, P. H., & Messing, R. O. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.003319 · Cited by 128
The crisis of (confidence in) global capitalism
Eichengreen, B. J. (2000) · Critical Review · doi:10.1080/08913810008443548 · Cited by 126
Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: Potential insight into their anti-addictive properties
Lominac, K. D., Kapasova, Z., Hannun, R. A., Patterson, C., Middaugh, L. D., & Szumlinski, K. K. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.04.003 · Cited by 124
Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: Blockade by the mGluR5 antagonist MPEP
Schroeder, J. P., Spanos, M., Stevenson, J. R., Besheer, J., Salling, M. C., & Hodge, C. W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.057 · Cited by 124
Glutamate, GABA, and other cortical metabolite concentrations during early abstinence from alcohol and their associations with neurocognitive changes
Mon, A., Durazzo, T. C., & Meyerhoff, D. J. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.03.012 · Cited by 124
Metabotropic Glutamate Receptor 5 Activity in the Nucleus Accumbens Is Required for the Maintenance of Ethanol Self-Administration in a Rat Genetic Model of High Alcohol Intake
Besheer, J., Grondin, J. J. M., Cannady, R., Sharko, A. C., Faccidomo, S., & Hodge, C. W. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.016 · Cited by 123
Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: Relationship to acamprosate actions
Blednov, Y. A., & Adron Harris, R. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008584 · Cited by 123
Ethanol and NMDA Receptor Signaling
Woodward, J. J. (2000) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v14.i1.40 · Cited by 123
Ionotropic Glutamate Receptor Antagonists Modulate Cue‐Induced Reinstatement of Ethanol‐Seeking Behavior
Bäckström, P., & Hyytiä, P. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000122101.13164.21 · Cited by 122
The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems
Cowen, M. S., Djouma, E., & Lawrence, A. J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.090449 · Cited by 120
Ethanol Inhibition ofN-Methyl-d-aspartate Receptors Is Reduced by Site-directed Mutagenesis of a Transmembrane Domain Phenylalanine Residue
Ronald, K. M., Mirshahi, T., & Woodward, J. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102800200 · Cited by 119
Systematic Analysis of Glutamatergic Neurotransmission Genes in Alcohol Dependence and Adolescent Risky Drinking Behavior
Schumann, G., Johann, M., Frank, J., Preuss, U. W., Dahmen, N., Laucht, M., Rietschel, M., Rujescu, D., Lourdusamy, A., Clarke, T., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.7.826 · Cited by 116
Self-citation
Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients
Krupitsky, E. M., Neznanova, O., Masalov, D. V., Burakov, A. M., Didenko, T., Romanova, T. N., Tsoy, M., Bespalov, A., Slavina, T. Y., Grinenko, A. Y., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.519 · Cited by 116
Self-citation
Effects of Topiramate on Urge to Drink and the Subjective Effects of Alcohol: A Preliminary Laboratory Study
Miranda, R., MacKillop, J. M., Monti, P. M., Rohsenow, D. J., Tidey, J. W., Gwaltney, C. J., Swift, R. M., Ray, L. A., & McGeary, J. E. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00592.x · Cited by 115
Effects of the mGlu2/3 Agonist LY379268 and the mGlu5 Antagonist MTEP on Ethanol Seeking and Reinforcement Are Differentially Altered in Rats with a History of Ethanol Dependence
Sidhpura, N., Weiss, F., & Martin‐Fardon, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.005 · Cited by 114
Long-lasting Modulation of Glutamatergic Transmission in VTA Dopamine Neurons after a Single Dose of Benzodiazepine Agonists
Panhelainen, A. E., Möykkynen, T. P., & Korpi, E. R. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.89 · Cited by 109
Chronic Ethanol Upregulates NMDA and AMPA, but Not Kainate Receptor Subunit Proteins in Rat Primary Cortical Cultures
Chandler, L. J., Norwood, D., & Sutton, G. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04123.x · Cited by 109
THE GLYCINE REUPTAKE INHIBITOR ORG 25935 DECREASES ETHANOL INTAKE AND PREFERENCE IN MALE WISTAR RATS
Molander, A., Lidö, H. H., Löf, E., Ericson, M., & Söderpalm, B. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl085 · Cited by 109
Chronic Ethanol Ingestion Facilitates N-Methyl-d-aspartate Receptor Function and Expression in Rat Lateral/Basolateral Amygdala Neurons
Floyd, D. W., Jung, K.-Y., & McCool, B. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.057505 · Cited by 109
Actions of ?-cycloserine at the ? glycine receptor site in vivo
Emmett, M. R. (1991) · Neuropharmacology · doi:10.1016/0028-3908(91)90161-4 · Cited by 108
Nucleus Accumbens m G lu R 5‐Associated Signaling Regulates Binge Alcohol Drinking Under Drinking‐in‐the‐Dark Procedures
Cozzoli, D. K., Courson, J. A., Caruana, A. L., Miller, B. W., Greentree, D. I., Thompson, A. B., Wroten, M. G., Zhang, P.-W., Xiao, B., Hu, J., et al. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01776.x · Cited by 105
Intracellular signaling pathways that regulate behavioral responses to ethanol
Newton, P. M., & Messing, R. O. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.07.004 · Cited by 104
Differential Effects of Chronic Ethanol Consumption and Withdrawal on Homer/Glutamate Receptor Expression in Subregions of the Accumbens and Amygdala of P Rats
Obara, I., Bell, R. L., Goulding, S. P., Reyes, C. M., Larson, L. A., Ary, A. W., Truitt, W. A., & Szumlinski, K. K. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01030.x · Cited by 104
mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior
Sinclair, C. M., Cleva, R. M., Hood, L. E., Olive, M. F., & Gass, J. T. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.01.014 · Cited by 102
Ethanol-Mediated Facilitation of AMPA Receptor Function in the Dorsomedial Striatum: Implications for Alcohol Drinking Behavior
Wang, J., Hamida, S. B., Darcq, E., Zhu, W., Gibb, S. L., Lanfranco, M. F., Carnicella, S., & Dorit Ron, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2783-12.2012 · Cited by 102
A Pilot Double‐Blind Treatment Trial of Memantine for Alcohol Dependence
Evans, S. M., LEVIN, F. R., Brooks, D. J., & Garawi, F. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00360.x · Cited by 101
Loss of Glial Glutamate and Aspartate Transporter (Excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and Metabotropic Glutamate 2/3 Agonist
Karlsson, R., Tanaka, K., Heilig, M. A., & Holmes, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.001 · Cited by 100
Self-citation
Naltrexone in the treatment of alcohol dependence
Mangado, E. O. (1994) · Alcohol · doi:10.1016/0741-8329(94)90014-0 · Cited by 100
GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis
Wills, T. A., Klug, J. R., Silberman, Y., Baucum, A. J., Weitlauf, C., Colbran, R. J., Delpire, E., & Winder, D. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113820109 · Cited by 98
Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons
Carta, M., Ariwodola, O. J., Weiner, J. L., & Valenzuela, C. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1137276100 · Cited by 98
Regulation of Motivation to Self‐Administer Ethanol by mGluR5 in Alcohol‐Preferring (P) Rats
Besheer, J., Faccidomo, S., Grondin, J. J. M., & Hodge, C. W. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00570.x · Cited by 97
Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol
Dorit Ron, A. (2004) · The Neuroscientist · doi:10.1177/1073858404263516 · Cited by 97
Blockade of the acquisition of ethanol-induced conditioned place preference by N-methyl-D-aspartate receptor antagonists.
a, G. B., & ska, J. K. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.2.175 · Cited by 94
Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons
Popp, R. L., & Lovinger, D. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00195-3 · Cited by 93
Glycine Receptors Regulate Dopamine Release in the Rat Nucleus Accumbens
Molander, A., & S�derpalm, B. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000150006.17168.f7 · Cited by 92
The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats
Rodd, Z. A., McKinzie, D. L., Bell, R. L., McQueen, V. K., MURPHY, J., Schoepp, D. D., & McBride, W. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.032 · Cited by 89
Ethanol and N -methyl- D -aspartate receptor complex interactions: a detailed drug discrimination study in the rat
Hundt, W., Danysz, W., Hölter, S. M., & Spanagel, R. (1998) · Psychopharmacology · doi:10.1007/s002130050484 · Cited by 87
Self-citation
Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm
Abulseoud, O. A., Miller, J. D., Wu, J., Choi, D., & Holschneider, D. P. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.045 · Cited by 87
Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats
Sari, Y., & Sreemantula, S. N. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.007 · Cited by 86
Ethanol and brain plasticity: receptors and molecular networks of the postsynaptic density as targets of ethanol
Chandler, L. J. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00096-2 · Cited by 85
Locomotor Sensitization to Ethanol Impairs NMDA Receptor-Dependent Synaptic Plasticity in the Nucleus Accumbens and Increases Ethanol Self-Administration
Abrahao, K. P., Ariwodola, O. J., Butler, T. R., Rau, A. R., Skelly, M. J., Carter, E., Alexander, N. P., McCool, B. A., Formigoni, M. L. O. D. S., & Weiner, J. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5839-11.2013 · Cited by 84
Effects of Acamprosate on Excitatory Amino Acids During Multiple Ethanol Withdrawal Periods
Dahchour, A., & Witte, P. D. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000056617.68874.18 · Cited by 82
Acute effects of memantine in combination with alcohol in moderate drinkers
Bisaga, A. M., & Evans, S. M. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1617-5 · Cited by 82
New Pharmacological Treatment Strategies for Relapse Prevention
Spanagel, R., & Vengeliene, V. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_205 · Cited by 81
Self-citation
Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
Dildy‐Mayfield, J. E., & Harris, R. A. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10784-2 · Cited by 80
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats
Adams, C. L., Cowen, M. S., Short, J. L., & Lawrence, A. J. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007845 · Cited by 78
Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
von der Goltz, C., Vengeliene, V., Bilbao, A., Perreau‐Lenz, S., Pawlak, C. R., Kiefer, F., & Spanagel, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1544-1 · Cited by 77
Self-citation
Acute Effects of Acamprosate and MPEP on Ethanol Drinking‐in‐the‐Dark in Male C57BL/6J Mice
Gupta, T., Syed, Y. M., Revis, A. A., Miller, S. A., Martinez, M., Cohn, K. A., Demeyer, M. R., Patel, K. Y., Brzezinska, W. J., & Rhodes, J. S. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00787.x · Cited by 76
Chronic intermittent ethanol and withdrawal differentially modulate basolateral amygdala AMPA-type glutamate receptor function and trafficking
Christian, D., Alexander, N. J., Diaz, M. R., Robinson, S. L., & McCool, B. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.017 · Cited by 76
Dose-Ranging Kinetics and Behavioral Pharmacology of Naltrexone and Acamprosate, Both Alone and Combined, in Alcohol-Dependent Subjects
Johnson, B. A., O’Malley, S. S., Ciraulo, D. A., Roache, J. D., Chambers, R. A., Sarid‐Segal, O., & Couper, D. J. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000084029.22282.bb · Cited by 76
Glycine Transporter-1 Blockade Leads to Persistently Reduced Relapse-like Alcohol Drinking in Rats
Vengeliene, V., Leonardi‐Essmann, F., Sommer, W. H., Marston, H. M., & Spanagel, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.029 · Cited by 76
Self-citation
Ethanol Inhibits α-Amino-3-hydyroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Function in Central Nervous System Neurons by Stabilizing Desensitization
Möykkynen, T. P., Korpi, E. R., & Lovinger, D. M. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.050666 · Cited by 74
Cortical Gamma-Aminobutyric Acid Levels and the Recovery from Ethanol Dependence: Preliminary Evidence of Modification by Cigarette Smoking
Mason, G. F., Petrakis, I. L., de Graaf, R. A., Gueorguieva, R. V., Guidone, E., Coric, V., Epperson, C. N., Rothman, D. L., & Krystal, J. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.009 · Cited by 73
Self-citation
Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit
Boyce‐Rustay, J. M., & Holmes, A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0448-6 · Cited by 73
Self-citation
Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens
Adermark, L., Clarke, R. B. C., Olsson, T., Hansson, E., Söderpalm, B., & Ericson, M. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00206.x · Cited by 71
Effects of Topiramate in the Treatment of Alcohol Dependence
Rubio, G., Ponce, G., Jiménez‐Arriero, M. Á., Palomo, T., Manzanares, J., & Ferre, F. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-815473 · Cited by 71
Alcohol Inhibits NR2B-Containing NMDA Receptors in the Ventral Bed Nucleus of the Stria Terminalis
Kash, T. L., Matthews, R. T., & Winder, D. G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301504 · Cited by 71
Chronic Intermittent Ethanol Treatment Selectively Alters N-Methyl-d-aspartate Receptor Subunit Surface Expression in Cultured Cortical Neurons
Qiang, M., Denny, A. D., & Ticku, M. K. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.033043 · Cited by 70
Treatment of alcohol dependence with low-dose topiramate: an open-label controlled study
Paparrigopoulos, T. J., Tzavellas, E., Karaiskos, D., Kourlaba, G., & Liappas, I. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-41 · Cited by 70
Using Topiramate or Naltrexone for the Treatment of Alcohol‐Dependent Patients
Flórez, G., García‐Portilla, M. P., Álvarez, S., Sáiz, P. A., Nogueiras, L., & Bobes, J. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00680.x · Cited by 69
The Thorny Side of Addiction: Adaptive Plasticity and Dendritic Spines
Mulholland, P. J., & Chandler, L. J. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.247 · Cited by 69
Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice
Bird, M. K., Kirchhoff, J. E., Djouma, E., & Lawrence, A. J. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008572 · Cited by 68
Metabotropic glutamate receptor subtype 5 antagonism in learning and memory
Simonyi, Á., Schachtman, T. R., & Christoffersen, G. R. J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.12.039 · Cited by 66
Effects of MPEP on expression of food‐, MDMA‐ or amphetamine‐conditioned place preference in rats
Herzig, V., Capuani, E. M., Kovar, K., & Schmidt, W. (2005) · Addiction Biology · doi:10.1080/13556210500223272 · Cited by 65
The effects of alcoholism on the human basolateral amygdala
Kryger, R., & Wilce, P. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.061 · Cited by 64
Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat
Spanagel, R., Zieglgänsberger, W., & Hundt, W. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00176-8 · Cited by 63
Self-citation
Novelty-Seeking Behaviors and the Escalation of Alcohol Drinking After Abstinence in Mice Are Controlled by Metabotropic Glutamate Receptor 5 on Neurons Expressing Dopamine D1 Receptors
Parkitna, J. M. R., Sikora, M., Gołda, S., Gołembiowska, K., Bystrowska, B., Engblom, D., Bilbao, A., & Przewłocki, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.019 · Cited by 63
Ethanol Inhibition of Synaptically Evoked Kainate Responses in Rat Hippocampal CA3 Pyramidal Neurons
Weiner, J. L., Dunwiddie, T. V., & Valenzuela, C. F. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.1.85 · Cited by 63
Alcohol-Induced Neurodegeneration, Suppression of Transforming Growth Factor-β, and Cognitive Impairment in Rats: Prevention by Group II Metabotropic Glutamate Receptor Activation
Cippitelli, A., Damadzic, R., Frankola, K., Goldstein, A., Thorsell, A., Singley, E., Eskay, R. L., & Heilig, M. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.018 · Cited by 62
Modulation of NMDA receptors by glycine ? introduction to some basic aspects and recent developments
Parsons, C. G., Danysz, W., Hesselink, M. B., Hartmann, S., Lorenz, B., Wollenburg, C., & Quack, G. (1998) · Amino Acids · doi:10.1007/bf01345264 · Cited by 62
Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism
Cowen, M. S., Krstew, E., & Lawrence, A. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0583-0 · Cited by 61
Chronic ethanol ingestion modulates proanxiety factors expressed in rat central amygdala
Läck, A. K., Floyd, D. W., & McCool, B. A. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.07.004 · Cited by 61
d-Cycloserine Facilitates Extinction of Conditioned Alcohol-Seeking Behaviour in Rats
Vengeliene, V., Kiefer, F., & Spanagel, R. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn067 · Cited by 57
Self-citation
Role of protein kinase C epsilon (PKCɛ) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell
Gass, J. T., & Olive, M. F. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1490-y · Cited by 57
Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice
Cowen, M. S., Schroff, K.-C., Gass, P., Sprengel, R., & Spanagel, R. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00174-6 · Cited by 57
Self-citation
Expression of behavioral sensitization to ethanol by DBA/2J mice: the role of NMDA and non-NMDA glutamate receptors
Broadbent, J., Kampmueller, K. M., & Koonse, S. A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1404-3 · Cited by 57
Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats
Cagetti, E., Baicy, K., & Olsen, R. W. (2003) · Neuroreport · doi:10.1097/00001756-200401190-00040 · Cited by 56
A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference
Camp, M., Feyder, M. J., Ihne, J. L., Palachick, B., Hurd, B., Karlsson, R., Noronha, B., Chen, Y.-C., Coba, M. P., Grant, S. G. N., et al. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00282.x · Cited by 55
Self-citation
Acute Effects of Ethanol on Kainate Receptors in Cultured Hippocampal Neurons
da Costa, E. T., Soto, E. E., Cardoso, R. A., Olivera, D. S., & Valenzuela, C. F. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04594.x · Cited by 53
Enhanced AMPA receptor activity increases operant alcohol self‐administration and cue‐induced reinstatement
Cannady, R., Fisher, K. R., Durant, B., Besheer, J., & Hodge, C. W. (2012) · Addiction Biology · doi:10.1111/adb.12000 · Cited by 52
Effects of d ‐Cycloserine on Extinction and Reconditioning of Ethanol‐Seeking Behavior in Mice
Groblewski, P. A., Lattal, K. M., & Cunningham, C. L. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00895.x · Cited by 52
Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration
Kufahl, P. R., Watterson, L. R., Nemirovsky, N. E., Hood, L. E., Villa, A., Halstengard, C., Zautra, N., & Olive, M. F. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.037 · Cited by 52
PER2 Variation is Associated with Diurnal Preference in a Korean Young Population
Lee, H., Kim, L., Kang, S., Yoon, H., Choi, J.-E., Park, Y.-M., Kim, S. J., & Kripke, D. F. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9396-3 · Cited by 52
The Role of NMDA Receptor Binding Sites in Ethanol Place Conditioning.
Boyce‐Rustay, J. M., & Cunningham, C. L. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.4.822 · Cited by 52
Disruption of Operant Oral Self‐Administration of Ethanol, Sucrose, and Saccharin by the AMP/Kainate Antagonist, NBQX, but Not the AMPA Antagonist, GYKI 52466
Stephens, D., & Brown, G. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04091.x · Cited by 52
Topiramate Moderately Reduces the Motivation to Consume Alcohol and Has a Marked Antidepressant Effect in Rats
Hargreaves, G. A., & McGregor, I. S. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00485.x · Cited by 51
Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala
Läck, A. K., Ariwodola, O. J., Chappell, A. M., Weiner, J. L., & McCool, B. A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.026 · Cited by 51
Topiramate reduces ethanol consumption by C57BL/6 mice
Nguyen, S. A., Malcolm, R. J., & Middaugh, L. D. (2006) · Synapse · doi:10.1002/syn.20350 · Cited by 50
The glycine reuptake inhibitor Org24598 and acamprosate reduce ethanol intake in the rat; tolerance development to acamprosate but not to Org24598
Lidö, H. H., Marston, H. M., Ericson, M., & Söderpalm, B. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00367.x · Cited by 49
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Self-citation
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Knapp, C. M., Mercado, M., Markley, T. L., Crosby, S. J., Ciraulo, D. A., & Kornetsky, C. H. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.04.001 · Cited by 41
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Authors: Holmes, A., Spanagel, R., & Krystal, J. H.
Affiliations: National Institutes of Health (US)
Heidelberg University (DE)
Yale University (US)
Corresponding author: Holmes, Andrew
ORCID: Holmes, Andrew
Spanagel, Rainer
Krystal, John H.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2013-09-01
Volume: 229
Issue: 3
Pages: 539-554
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-013-3226-2
PMC: PMC3811052
OpenAlex: W2104412023
Cited by: 197
References: 221
Citations by year: 2026: 7 · 2025: 14 · 2024: 10 · 2023: 5 · 2022: 7 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 22 · 2017: 14 · 2016: 25 · 2015: 29 · 2014: 17 · 2013: 1
FWCI: 2.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (P50AA012870, ZIAAA000411)
National Center for Research Resources (UL1RR024139)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: glutamatergic system, alcoholism, alcoholism pharmacotherapy, NMDA receptor, NMDA receptor glycine site, AMPA receptors, kainate receptors, metabotropic glutamate receptors, mGluR5, glutamate transporters, GluN2B, GluA3, alcohol withdrawal, alcohol craving, alcohol seeking, chronic ethanol exposure, glutamate excitotoxicity
MeSH terms: Alcoholism, Animals, Humans, Substance Withdrawal Syndrome, Receptors, N-Methyl-D-Aspartate, Receptors, AMPA, Kainic Acid Receptors, Glutamic Acid, Protein Subunits, Molecular Targeted Therapy, Drug-Seeking Behavior

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