Spanagel, Rainer

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 919

REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview

Sanchis‐Segura, C., & Spanagel, R. (2006) · Addiction Biology

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 629

The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption

Spanagel, R., Pendyala, G., Abarca, C., Zghoul, T., Sanchis-Segura, C., Magnone, M. C., Lascorz, J., Depner, M., Holzberg, D., Soyka, M., et al. (2005) · Nature Medicine

Circadian rhythm and melatoninNeuroscience and Neuropharmacology Research

Cited by 594

The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study

Spanagel, R., Herz, A., & Shippenberg, T. S. (1990) · Journal of Neurochemistry

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 539

Adolescent impulsivity phenotypes characterized by distinct brain networks

the IMAGEN Consortium, Whelan, R., Conrod, P. J., Poline, J.-B., Lourdusamy, A., Banaschewski, T., Barker, G. J., Bellgrove, M. A., Büchel, C., Byrne, M., et al. (2012) · Nature Neuroscience

Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 420

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene ( AUTS2 ) in the regulation of alcohol consumption

Schumann, G., Coin, L. J., Lourdusamy, A., Charoen, P., Berger, K. H., Stacey, D., Desrivières, S., Aliev, F. A., Khan, A. A., Amin, N., et al. (2011) · Proceedings of the National Academy of Sciences

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 264

Glutamatergic targets for new alcohol medications

Holmes, A., Spanagel, R., & Krystal, J. H. (2013) · Psychopharmacology

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 197

Risk taking and the adolescent reward system: A potential common link to substance abuse

Schneider, S., Peters, J., Bromberg, U., Brassen, S., Miedl, S. F., Banaschewski, T., Barker, G. J., Conrod, P., Flor, H., Garavan, H., et al. (2012) · American Journal of Psychiatry

Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 186

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples

Treutlein, J., Kissling, C., Frank, J., Wiemann, S., Dong, L., Depner, M., Saam, C., Lascorz, J., Soyka, M., Preuss, U. W., et al. (2006) · Molecular Psychiatry

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 186

Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications.

Bilbao, A., & Spanagel, R. (2022) · BMC Medicine

Cannabis and Cannabinoid ResearchComplementary and Alternative Medicine Studies

Cited by 181

Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit

Schmahl, C., Herpertz, S. C., Bertsch, K., Ende, G., Flor, H., Kirsch, P., Lis, S., Meyer-Lindenberg, A., Rietschel, M., Schneider, M., et al. (2014) · Borderline Personality Disorder and Emotion Dysregulation

Personality Disorders and PsychopathologyNeural and Behavioral Psychology Studies

Cited by 168

Effect of Acamprosate on Magnetic Resonance Spectroscopy Measures of Central Glutamate in Detoxified Alcohol-Dependent Individuals: A Randomized Controlled Experimental Medicine Study

Umhau, J. C., Momenan, R., Schwandt, M. L., Singley, E., Lifshitz, M., Doty, L., Adams, L. J., Vengeliene, V., Spanagel, R., Zhang, Y., et al. (2010) · Archives of General Psychiatry

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 144

Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex

Pfarr, S., Meinhardt, M. W., Klee, M. L., Hansson, A. C., Vengeliene, V., Schonig, K., Bartsch, D., Hope, B. T., Spanagel, R., & Sommer, W. H. (2015) · Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Cited by 143

Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions

Spanagel, R. (2020) · Dialogues in Clinical Neuroscience

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 127

Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder

Zieker, J., Zieker, D., Jatzko, A., Dietzsch, J., Nieselt, K., Schmitt, A., Bertsch, T., Fassbender, K., Spanagel, R., Northoff, H., et al. (2007) · Molecular Psychiatry

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 127

Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

Büchel, C., Peters, J., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Conrod, P. J., Flor, H., Papadopoulos, D., Garavan, H., Gowland, P., et al. (2017) · Nature Communications

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 118

Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans

Hansson, A. C., Koopmann, A., Uhrig, S., Bühler, S., Domi, E., Kiessling, E., Ciccocioppo, R., Froemke, R. C., Grinevich, V., Kiefer, F., et al. (2018) · Neuropsychopharmacology

Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

Cited by 109

Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats

Hölter, S. M., Henniger, M. S. H., Lipkowski, A. W., & Spanagel, R. (2000) · Psychopharmacology

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 100

A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus

Ekhtiari, H., Zare-Bidoky, M., Sangchooli, A., Janes, A. C., Kaufman, M. J., Oliver, J. A., Prisciandaro, J. J., Wüstenberg, T., Anton, R. F., Bach, P., et al. (2022) · Nature Protocols

Substance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Cited by 89

Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling

Schneider, P., Bindila, L., Schmahl, C., Bohus, M., Meyer-Lindenberg, A., Lutz, B., Spanagel, R., & Schneider, M. (2016) · Frontiers in Behavioral Neuroscience

Cannabis and Cannabinoid ResearchNeuroendocrine regulation and behavior

Cited by 89

Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism

Meinhardt, M. W., Pfarr, S., Fouquet, G., Rohleder, C., Meinhardt, M. L., Barroso-Flores, J., Hoffmann, R., Jeanblanc, J., Paul, E., Wagner, K., et al. (2021) · Science Advances

Neurotransmitter Receptor Influence on BehaviorPsychedelics and Drug Studies

Cited by 89

Boys do it the right way: sex-dependent amygdala lateralization during face processing in adolescents

Schneider, S., Peters, J., Bromberg, U., Brassen, S., Menz, M. M., Miedl, S. F., Loth, E., Banaschewski, T., Barbot, A., Barker, G., et al. (2011) · NeuroImage

Hemispheric Asymmetry in NeuroscienceFace Recognition and Perception

Cited by 84

Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse

Meinhardt, M. W., Güngör, C., Skorodumov, I., Mertens, L. J., & Spanagel, R. (2020) · Neuropsychopharmacology

Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 65

Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis

Hermann, D., Hirth, N., Reimold, M., Batra, A., Smolka, M. N., Hoffmann, S., Kiefer, F., Noori, H. R., Sommer, W. H., Reischl, G., et al. (2017) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 64