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Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood
Abstract
The neonatal ibotenic acid lesion of the ventral hippocampus in the rat is an animal model of several aspects of schizophrenia. This lesion produces a number of behavioural abnormalities, such as hyperlocomotion and deficits in prepulse inhibition of startle, that present themselves relatively late in development, i.e. after puberty. Some of these abnormalities, which are thought to model the positive symptoms of schizophrenia, can be normalized by chronic treatment with neuroleptics. In the present study, we examined the effects of the neonatal hippocampal lesion on social behaviour. Social withdrawal and isolation are key components of the negative symptoms of schizophrenia that have not been previously addressed in this model. Rats were lesioned on postnatal day 7 (PD7) and tested for social interaction on PD35 and PD65. They were then treated with clozapine (1.9 and 7.4 micromol/kg or 0.63 and 2.5 mg/kg) for 21 days and retested. The results show that although, as previously reported, spontaneous hyperlocomotion emerged in the lesioned rats only after puberty (PD65), social interaction deficits and behaviors that may reflect anxiety were present at both PD35 and PD65. Clozapine normalized locomotion, but did not ameliorate putative anxiety or social interaction deficits in the neonatally lesioned rats. Our results indicate that the neonatal hippocampal lesion in the rat models some aspects of both positive and negative symptoms of schizophrenia. The effects of clozapine appear inconsistent with its putative benefit for negative symptoms.
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“Behaviorally, adult rats with a NVHL show hyperlocomotion, 39,40 increased response to novelty, 41 abnormal social behaviors, 41 exaggerated responses to stress, stimulants and NMDA antagonists, 39,42 and increased liability for addictive behaviors.43,44”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [41]
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Prefrontal Cortical Circuits and Schizophrenia Pathophysiology
O’Donnell, P. (2007) · Springer eBooks · doi:10.1007/978-0-387-72256-6_21 · Cited by 2
Cellular and Circuit Models of Increased Resting State Network Gamma Activity in Schizophrenia
White, R. S., & Siegel, S. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801829-3.00022-7 · Cited by 2
Guzmán‐Velázquez, S., Garcés‐Ramírez, L., Flores, G., de la Cruz, F., & Zamudio, S. (2011) · International Journal of Medicinal Chemistry · doi:10.1155/2011/648960 · Cited by 2
Yabuki, Y., Nakagawasai, O., Tadano, T., & Fukunaga, K. (2013) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.12-00278-3 · Cited by 2
Metadata
- Authors
- Sams-Dodd, F., Lipska, B. K., & Weinberger, D. R.
- Affiliations
- National Institutes of Health (US)
- Venue
- Psychopharmacology
- Published
- 1997-08-05
- Volume
- 132
- Issue
- 3
- Pages
- 303-310
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2036180008
- Cited by
- 346
- References
- 17
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 14 · 2015: 15 · 2014: 21 · 2013: 14 · 2012: 17
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- ventral hippocampus, ibotenic acid, animal models of schizophrenia, social behavior, social withdrawal, negative symptoms of schizophrenia, positive symptoms, hyperlocomotion, clozapine, antipsychotic drugs, anxiety, social interaction deficits
- MeSH terms
- Animals, Animals, Newborn, Behavior, Animal, Clozapine, Female, Hippocampus, Male, Motor Activity, Social Behavior, Antipsychotic Agents, Rats, Sprague-Dawley, Rats
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