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Cited by 347Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood

Sams-Dodd, F., Lipska, Barbara K., Weinberger, Daniel R.·1997·Psychopharmacology
DOI 10.1007/s002130050349
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Abstract

The neonatal ibotenic acid lesion of the ventral hippocampus in the rat is an animal model of several aspects of schizophrenia. This lesion produces a number of behavioural abnormalities, such as hyperlocomotion and deficits in prepulse inhibition of startle, that present themselves relatively late in development, i.e. after puberty. Some of these abnormalities, which are thought to model the positive symptoms of schizophrenia, can be normalized by chronic treatment with neuroleptics. In the present study, we examined the effects of the neonatal hippocampal lesion on social behaviour. Social withdrawal and isolation are key components of the negative symptoms of schizophrenia that have not been previously addressed in this model. Rats were lesioned on postnatal day 7 (PD7) and tested for social interaction on PD35 and PD65. They were then treated with clozapine (1.9 and 7.4 micromol/kg or 0.63 and 2.5 mg/kg) for 21 days and retested. The results show that although, as previously reported, spontaneous hyperlocomotion emerged in the lesioned rats only after puberty (PD65), social interaction deficits and behaviors that may reflect anxiety were present at both PD35 and PD65. Clozapine normalized locomotion, but did not ameliorate putative anxiety or social interaction deficits in the neonatally lesioned rats. Our results indicate that the neonatal hippocampal lesion in the rat models some aspects of both positive and negative symptoms of schizophrenia. The effects of clozapine appear inconsistent with its putative benefit for negative symptoms.

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Metadata

Authors
Sams-Dodd, F., Lipska, B. K., & Weinberger, D. R.
Affiliations
National Institutes of Health (US)
ORCID
Weinberger, Daniel R.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1997-08-05
Volume
132
Issue
3
Pages
303-310
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s002130050349
OpenAlex
W2036180008
Cited by
346
References
17
Citations by year
2026: 6 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 14 · 2015: 15 · 2014: 21 · 2013: 14 · 2012: 17
FWCI
7.20
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
ventral hippocampus, ibotenic acid, animal models of schizophrenia, social behavior, social withdrawal, negative symptoms of schizophrenia, positive symptoms, hyperlocomotion, clozapine, antipsychotic drugs, anxiety, social interaction deficits
MeSH terms
Animals, Animals, Newborn, Behavior, Animal, Clozapine, Female, Hippocampus, Male, Motor Activity, Social Behavior, Antipsychotic Agents, Rats, Sprague-Dawley, Rats

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