Both nicotine and mecamylamine block dizocilpine-induced explosive jumping behavior in mice: psychiatric implications
Abstract
Dizocilpine (MK-801) administration to an outbred strain of NIH Swiss mice elicits discrete episodes of explosive jumping behavior designated as "popping." This behavior may serve as a useful preclinical paradigm for the screening of potentially novel antipsychotic medications. Both nicotine and mecamylamine, a nicotinic antagonist, dose-dependently blocked dizocilpine-induced popping. The data suggest that nicotine may be of therapeutic benefit in the treatment of schizophrenia and that some of its effects may be mediated by non-nicotinic receptors.
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The agonist nicotine and the antagonist mecamylamine both exert antidepressant-like effects.
“Behavioral studies also show that the agonist nicotine and the antagonist mecamylamine both improve memory-related task performance in rodents and monkeys (Buccafusco and Jackson, 1991;Terry et al., 1999) and exert antidepressant-like effects (Semba et al., 1998;Tizabi et al., 1998;Shytle et al., 2002;Gatto et al., 2004).”
From Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization (2010) · cites this paper as Tizabi et al., 1998
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Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization
Bordia, T., Campos, C., McIntosh, J. M., & Quik, M. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162396 · Cited by 82 · see citing works
- Authors
- Tizabi, Y., Mastropaolo, J., Park, C. H., Riggs, R. L., Powell, D., Rosse, R. B., & Deutsch, S. I.
- Affiliations
- Howard University (US)
- United States Department of Veterans Affairs (US)
- ORCID
- Tizabi, Y.
- Venue
- Psychopharmacology
- Published
- 1998-11-16
- Volume
- 140
- Issue
- 2
- Pages
- 202-205
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2009879085
- Cited by
- 23
- References
- 0
- Citations by year
- 2025: 1 · 2012: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine, mecamylamine, MK-801, schizophrenia, nicotinic acetylcholine receptors, NMDA receptor antagonism, preclinical models
- MeSH terms
- Animals, Dose-Response Relationship, Drug, Male, Mecamylamine, Motor Activity, Nicotine, Schizophrenia, Dizocilpine Maleate, Mice
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