Interactions between social stress and morphine in the periaqueductal gray: effects on affective vocal and reflexive pain responses in rats
Abstract
Rationale Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. Objectives The present experiments evaluated the influence of opioid receptors within the PAG on affective vocal and reflexive responses to aversive stimuli in socially inexperienced, as well as defensive and submissive responses in defeated, adult male Long-Evans rats. Methods Defeat stress consisted of: (1) an aggressive confrontation with a "resident" stimulus rat in which the experimental "intruder" rat exhibited escape, defensive and submissive behaviors [i.e. upright, supine postures and ultrasonic vocalizations (USV)], and subsequently, (2) protection from the resident rat with a wire mesh screen for ca. 25 min. Defeat stress was immediately followed by an experimental session with thermal antinociceptive and tactile startle stimuli (20 psi airpuffs). Results The mu opioid receptor agonist morphine (0.3, 1, 3 microgram IC) attenuated startle-induced USV and the tail-flick reflex in socially inexperienced and defeated rats, with both groups of rats demonstrating equal sensitivity to morphine. Morphine decreased defeat-induced USV and increased the display of the crouch posture in defeated rats; these morphine effects in socially inexperienced and defeated rats were re- versed with the opioid receptor antagonist naltrexone (0.1…
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Social defeat stress provides a potential means to investigate components of the basic neuropathology underlying affective illnesses, which is providing fundamentally new information about the molecular basis of affective disorders to aid in the development of novel antidepressant treatment strategies.
“Thus, social defeat stress provides a potential means to investigate components of the basic neuropathology underlying affective illnesses8,33–36, which is providing fundamentally new information about the molecular basis of affective disorders to aid in the development of novel antidepressant treatment strategies20.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [36]
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The periaqueductal gray and defensive behavior: functional representation and neuronal organization.
Carrive, P. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90088-8 · Cited by 500 · see citing works
Role of the amygdala and periaqueductal gray in anxiety and panic.
Graeff, F. G., Silveira, M. C. L., Nogueira, R. L., Audi, E. A., & Oliveira, R. M. W. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90097-a · Cited by 301 · see citing works
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A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Animal models of social stress: Effects on behavior and brain neurochemical systems
Blanchard, R. J., McKittrick, C. R., & Blanchard, D. C. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00449-8 · Cited by 595 · see citing works
Response of the μ-opioid system to social rejection and acceptance
Hsu, D. T., Sanford, B. J., Meyers, K. K., Love, T. M., Hazlett, K. E., Wang, H., Ni, L., Walker, S. J., Mickey, B. J., Korycinski, S. T., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.96 · Cited by 225 · see citing works
Brunelli, S. A., & Hofer, M. A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.04.014 · Cited by 80 · see citing works
- Authors
- Vivian, J. A., & Miczek, K. A.
- Affiliations
- Tufts University (US)
- ORCID
- Miczek, Klaus A.
- Venue
- Psychopharmacology
- Published
- 1999-09-24
- Volume
- 146
- Issue
- 2
- Pages
- 153-161
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2046571010
- Cited by
- 42
- References
- 2
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2013: 4
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- morphine, periaqueductal gray, mu-opioid receptor, social defeat stress, ultrasonic vocalizations, startle response, tail-flick response, naltrexone, defensive behavior, submissiveness, endogenous opioids, aversive stimuli
- MeSH terms
- Aggression, Animals, Male, Morphine, Motor Activity, Narcotics, Pain, Pain Measurement, Periaqueductal Gray, Physical Stimulation, Reflex, Social Environment, Reflex, Startle, Stress, Psychological, Tape Recording, Videotape Recording, Vocalization, Animal, Receptors, Opioid, mu, Rats, Long-Evans, Rats
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