Laryngeal somatosensory deficits in Parkinson’s disease: implications for speech respiratory and phonatory control
Open accessAbstract
Parkinson's disease (PD) is often associated with substantial impairment of speech respiratory and phonatory control. However, the degree to which these impairments are related to abnormal laryngeal sensory function is unknown. This study examined whether individuals with PD exhibited abnormal and more asymmetric laryngeal somatosensory function compared with healthy controls, and whether these deficits were associated with disease and voice severity. Nineteen PD participants were tested and compared with 18 healthy controls. Testing included endoscopic assessment of laryngeal somatosensory function, with aerodynamic and acoustic assessment of respiratory and phonatory control, and clinical ratings of voice and disease severity. PD participants exhibited significantly abnormal and asymmetric laryngeal somatosensory function compared with healthy controls. Sensory deficits were significantly associated with timing of phonatory onset, voice intensity, respiratory driving pressure, laryngeal resistance, lung volume expended per syllable, disease severity, and voice severity. These results suggest that respiratory and phonatory control are influenced by laryngeal somatosensory function, that speech-related deficits in PD are related to abnormal laryngeal somatosensory function, and that this function may degrade as a function of disease severity. Thus, PD may represent a model of airway sensorimotor disintegration, highlighting the important role of the basal ganglia and related neural networks in the integration of laryngeal sensory input for speech-related motor control.
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Insufficient laryngeal function and abnormal laryngeal somatosensory function could have contributed to the lower vocal loudness in the participants.
“Insufficient laryngeal function and abnormal laryngeal somatosensory function could have contributed to the lower vocal loudness in our participants [54, 55].”
From Comparing face-to-face and online LSVT®LOUD speech training using LSVT®Coach in patients with Parkinson’s disease: a pilot randomised controlled trial (2025) · cites this paper as [54]
Sensory deficits in people with Parkinson's disease have been associated with factors such as timing of phonatory onset, voice intensity, respiratory driving pressure, laryngeal resistance, lung volume per syllable, disease severity, and speech-related impairment.
“Additionally, sensory deficits in people with PD have been associated with various factors such as the timing of phonatory onset, voice intensity, respiratory driving pressure, laryngeal resistance, lung volume per syllable, disease severity, and speech-related impairment [54].”
From Comparing face-to-face and online LSVT®LOUD speech training using LSVT®Coach in patients with Parkinson’s disease: a pilot randomised controlled trial (2025) · cites this paper as [54]
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- Liu H Wang EQ Metman LV Larson CR 2008 Vocal responses to loudness- and pitch-shift perturbations in individuals with Parkinson’s disease Abstracts from the 14th biennial speech motor control conference Monterey
- Vantipalli R Barlow SM 2004 AEROWIN RT clinical application for motor speech disorders Abstracts from the 12th biennial speech motor control conference Albuquerque
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Vocal Responses to Perturbations in Voice Auditory Feedback in Individuals with Parkinson's Disease
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“Additionally, sensory deficits in people with PD have been associated with various factors such as the timing of phonatory onset, voice intensity, respiratory driving pressure, laryngeal resistance, lung volume per syllable, disease severity, and speech-related impairment [54].”
- Authors
- Hammer, M. J., & Barlow, S. M.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Kansas (US)
- Corresponding author
- Hammer, Michael J.
- ORCID
- Barlow, Steven M.
- Venue
- Experimental Brain Research
- Published
- 2009-12-15
- Volume
- 201
- Issue
- 3
- Pages
- 401-409
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- PMC
- PMC2834233
- OpenAlex
- W1968510426
- Cited by
- 108
- References
- 69
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 2 · 2022: 11 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 4 · 2017: 10 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 13 · 2012: 6
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (DC005803, F31DC007260, DC007260, DC003311, L30 DC010356, R01DC003311, P30DC005803)
- National Center for Research Resources (K12RR023268, RR025012, KL2RR025012, RR023268)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD002528, HD-02528)
- Topics
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
- Keywords
- Parkinson's disease, speech control, respiratory control, phonation, vocal intensity, laryngeal resistance, disease severity, basal ganglia
- MeSH terms
- Aged, Disability Evaluation, Endoscopy, Female, Humans, Laryngeal Diseases, Laryngeal Muscles, Larynx, Male, Neurologic Examination, Parkinson Disease, Phonation, Respiratory Insufficiency, Respiratory Physiological Phenomena, Severity of Illness Index, Somatosensory Cortex, Speech Acoustics, Speech Production Measurement, Vital Capacity, Somatosensory Disorders, Dysphonia
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