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Cited by 35Bone health and osteoporosis researchHormonal and reproductive studiesVitamin D Research Studies

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Low Body Size and Elevated Sex-Hormone Binding Globulin Distinguish Men with Idiopathic Vertebral Fracture

Evans, S.F., Davie, M.W.J.·2002·Calcified Tissue International
DOI 10.1007/s00223-001-2018-6
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Abstract

Factors predisposing to vertebral fracture in men are less well defined compared with women. Most studies of osteoporosis in men have included patients with low bone mineral density (BMD), with or without vertebral fracture, or have included other fractures. To clarify these associations we investigated sex hormone levels, bone markers, and (indirectly) lean body mass (LBM) in 81 men with idiopathic vertebral fracture. Serum testosterone, estradiol, sex-hormone binding globulin (SHBG), 24-hr urinary creatinine (24-hr UCr), urinary free deoxypyridinoline (UfDPD) and serum type I procollagen carboxy-terminal propeptide, type I procollagen amino-terminal propeptide, type I collagen carboxy-terminal telopeptide, and osteocalcin were measured. SHBG was higher and 24-hr UCr lower in osteoporotic subjects. UfDPD was higher when corrected for 24-hr UCr. Serum bone turnover markers were not significantly increased, nor were serum sex hormones (and free hormone indices) significantly decreased in patients. SHBG levels were inversely related with lumbar spine and femoral neck BMD in both patients and control subjects. Free estradiol index was only correlated with BMD in men with osteoporosis. Body size is lower in men with established osteoporosis. The normal free hormone indices suggest that SHBG does not affect free hormone levels whereas the relationship between SHBG (but not sex hormones) and 24-hr UCr points to a relationship between SHBG and LBM. The association of high levels of…

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Metadata

Authors
Evans, S. F., & Davie, M. W. J.
Affiliations
Robert Jones and Agnes Hunt Orthopaedic Hospital (GB)
Venue
Calcified Tissue International
Publisher
Springer Science and Business Media LLC
Published
2002-01-01
Volume
70
Issue
1
Pages
9-15
ISSN
  • 0171-967X (ISSN-L)
  • 1432-0827
DOI
10.1007/s00223-001-2018-6
OpenAlex
W2038271538
Cited by
35
References
0
Citations by year
2023: 1 · 2022: 1 · 2021: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Calcified Tissue International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Keywords
male osteoporosis, sex hormone-binding globulin, lean body mass, bone mineral density, bone turnover markers, free estradiol, testosterone, urinary deoxypyridinoline, insulin-like growth factor I, lumbar spine, femoral neck
MeSH terms
Adult, Aged, Aged, 80 and over, Body Constitution, Creatinine, Estradiol, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Osteoporosis, Sex Hormone-Binding Globulin, Testosterone, Thoracic Vertebrae, Biomarkers, Absorptiometry, Photon, Bone Density, Spinal Fractures

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CoChat. (2026). Citation check: Low Body Size and Elevated Sex-Hormone Binding Globulin Distinguish Men with Idiopathic Vertebral Fracture. https://app.cochat.ai/papers/10.1007/s00223-001-2018-6
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Evans, S. F., & Davie, M. W. J. (2002). Low Body Size and Elevated Sex-Hormone Binding Globulin Distinguish Men with Idiopathic Vertebral Fracture. Calcified Tissue International. https://doi.org/10.1007/s00223-001-2018-6

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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