Effects of moderate endurance exercise on calcium, parathyroid hormone, and markers of bone metabolism in young women
Abstract
We investigated the short-term (1 hour-3 days) effects of a 45 minute run on calcium, parathyroid hormone, the carboxyterminal propeptide of type I procollagen (PICP), and the immunoactive carboxyterminal telopeptide of type I collagen in serum (ICTP) in young females. Fourteen healthy young women, aged 25.2 +/- 0.6 years (mean +/- SEM) with regular menstruations, participated. The test was outdoor jogging for 45 minutes at an intensity of 50% of VO2 max. Blood samples were collected 15 minutes before the test and 1, 24, and 72 hours after the test. The measured values were adjusted for changes in plasma volume. A significant decrease of ionized calcium was observed at 1 hour (P < 0.001) and 72 hours (P < 0.05) and a significant increase of parathyroid hormone (PTH) was noted 24 (P < 0.01) and 72 hours (P < 0.05) after the test. A significant decrease of PICP at 1 hour (P < 0.05) was followed by an increase after 24 (P < 0.01) and 72 hours (P < 0.001) and a significant increase in ICTP was noted at 24 and 72 hours (P < 0.05). A strong positive correlation was found between serum levels of PICP and ICTP (r = 0. 55-0.84; P < 0.05) throughout the experiment. In conclusion, young females showed biochemical signs of increased bone collagen turnover and altered homeostasis of calcium and PTH after a single bout of moderate endurance exercise.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Calcium homeostasis does not seem to be influenced by exercise.
“Calcium homeostasis does not seem to be influenced by exercise.”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [274]
Cites
Bone mineral content of amenorrheic and eumenorrheic athletes
Drinkwater, B. L., Nilson, K., Chesnut, C. H., Bremner, W. J., Shainholtz, S., & Southworth, M. B. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408023110501 · Cited by 956 · see citing works
Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen
Melkko, J., Niemi, S., Risteli, L., et al. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.7.1328 · Cited by 523 · see citing works
Evaluation of hemoconcentration from hematocrit measurements.
Beaumont, W. V. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.5.712 · Cited by 465 · see citing works
Bone Mineral Content of Amenorrheic and Eumenorrheic Athletes
Drinkwater, B. L., Nilson, K. L., Chesnut, C. H., Bremner, W. J., Shainholtz, S., & Southworth, M. B. (1985) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198503000-00014 · Cited by 458 · see citing works
Eriksen, E. F., Charles, P., Melsen, F., Mosekilde, L., Risteli, L., & Risteli, J. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080202 · Cited by 437 · see citing works
Physical Exercise as Prophylaxis against Involutional Vertebral Bone Loss: A Controlled Trial
Krølner, B. K., Toft, B., Nielsen, S. P., & Tøndevold, E. (1983) · Clinical Science · doi:10.1042/cs0640541 · Cited by 427 · see citing works
The effect of prolonged physical training on the properties of long bone: a study of Wolff's Law.
Woo, S. L., Kuei, S. C., Amiel, D., Gomez, M. A., Hayes, W. C., White, F. C., & Akeson, W. H. (1981) · PubMed · Cited by 421 · see citing works
Decreased spinal mineral content in amenorrheic women
Cann, C. E. (1984) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1984.03340290040017 · Cited by 409 · see citing works
Snow-Harter, C., Bouxsein, M., Lewis, B., Carter, D. R. P., & Marcus, R. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070706 · Cited by 383 · see citing works
Nilsson, B. E., & Westlin, N. E. (1971) · PubMed · Cited by 376 · see citing works
Journal of Bone and Mineral Research
Lanyon, L. E. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650071403 · Cited by 359 · see citing works
Vertebral Bone Loss: An Unheeded Side Effect of Therapeutic Bed Rest
Krølner, B. K., & Toft, B. (1983) · Clinical Science · doi:10.1042/cs0640537 · Cited by 357 · see citing works
The effect of prolonged physical training on the properties of long bone
Woo, S. L., Kuei, S. C., Amiel, D., Gomez, M. A., Hayes, W. C., White, F. C., & Akeson, W. H. (1981) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198163050-00013 · Cited by 343 · see citing works
Roach, H. I. (1994) · Cell Biology International · doi:10.1006/cbir.1994.1088 · Cited by 311 · see citing works
McSheehy, P. M. J., & Chambers, T. J. (1986) · Endocrinology · doi:10.1210/endo-119-4-1654 · Cited by 310 · see citing works
Taaffe, D. R., Snow-Harter, C., Connolly, D., Robinson, T. L., Brown, M. D., & Marcus, R. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100411 · Cited by 291 · see citing works
Perspectives: The role of changes in mechanical usage set points in the pathogenesis of osteoporosis
Frost, H. M. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070303 · Cited by 264 · see citing works
Strategies for prevention of osteoporosis and hip fracture.
Law, M. R., Wald, N., & Meade, T. W. (1991) · BMJ · doi:10.1136/bmj.303.6800.453 · Cited by 257 · see citing works
A two-year program of aerobics and weight training enhances bone mineral density of young women
Friedlander, A. L., Genant, H. K., Sadowsky, S. H., Byl, N. N., & Glüer, C. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100410 · Cited by 235 · see citing works
Pead, M. J., Skerry, T. M., & Lanyon, L. E. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030610 · Cited by 219 · see citing works
Mechanical loading stimulates rapid changes in periosteal gene expression
Cullen, D. M., Thiede, M. A., Petersen, D. N., Kimmel, D. B., & Recker, R. R. (1994) · Calcified Tissue International · doi:10.1007/bf00298562 · Cited by 211 · see citing works
Harter, L., Hruska, K. A., & Duncan, R. L. (1995) · Endocrinology · doi:10.1210/endo.136.2.7530647 · Cited by 205 · see citing works
Hormonal and Plasma Volume Alterations Following Endurance Exercise
Fellmann, N. (1992) · Sports Medicine · doi:10.2165/00007256-199213010-00004 · Cited by 176 · see citing works
Hodsman, A. B., Fraher, L. J., Østbye, T., et al. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116273 · Cited by 164 · see citing works
Lukert, B. P., HIGGINS, J. C., & Stoskopf, M. M. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-5-1056 · Cited by 154 · see citing works
Charles, P., Mosekilde, L., Risteli, L., Risteli, J., & Eriksen, E. F. (1994) · Bone and Mineral · doi:10.1016/s0169-6009(08)80147-x · Cited by 113 · see citing works
The effects of walking on the cross-sectional dimensions of the radius in postmenopausal women
Sandler, R. B., Cauley, J. A., Hom, D. L., Sashin, D., & Kriska, A. M. (1987) · Calcified Tissue International · doi:10.1007/bf02555246 · Cited by 101 · see citing works
Differences in basal and postexercise osteocalcin levels in athletic and nonathletic humans
Nishiyama, S., Tomoeda, S., Ohta, T., Higuchi, A., & Matsuda, I. (1988) · Calcified Tissue International · doi:10.1007/bf02571312 · Cited by 86 · see citing works
Dynamic bone loading exercises for postmenopausal women: effect on the density of the distal radius.
Ayalon, J., Simkin, A., Leichter, I. S., et al. (1987) · PubMed · Cited by 76 · see citing works
Kristoffersson, A., Hultdin, J., Holmlund, I., et al. (1995) · International Journal of Sports Medicine · doi:10.1055/s-2007-972982 · Cited by 69 · see citing works
Self-citationThe response of the skeleton to physical training: a biochemical study in horses
Price, J. S., Jackson, B., Eastell, R., et al. (1995) · Bone · doi:10.1016/8756-3282(95)00221-x · Cited by 65 · see citing works
Effect of concentric exercise on serum muscle and collagen markers
Virtanen, P., Viitasalo, J. T., Vuori, J., et al. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1272 · Cited by 64 · see citing works
Anabolic effect of high doses of human parathyroid hormone (1–38) in mature intact female rats
Jerome, C. P. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090619 · Cited by 55 · see citing works
Cheng, M. Z., Zaman, G., & Lanyon, L. E. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090606 · Cited by 53 · see citing works
Cultured embryonic bone shafts show osteogenic responses to mechanical loading
Zaman, G., Dallas, S. L., & Lanyon, L. E. (1992) · Calcified Tissue International · doi:10.1007/bf00298501 · Cited by 51 · see citing works
Intact serum parathyroid hormone levels increase during running exercise in well-trained men
Salvesen, H., Johansson, A. G., Foxdal, P., WIDE, L. E., Piehl‐Aulin, K., & Ljunghall, S. (1994) · Calcified Tissue International · doi:10.1007/bf00295947 · Cited by 50 · see citing works
PROLONGED LOW‐INTENSITY EXERCISE RAISES THE SERUM PARATHYROID HORMONE LEVELS
Ljunghall, S., JOBORN, H., Roxin, L. E., Rastad, J., WIDE, L. E., & Åkerström, G. (1986) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1986.tb03606.x · Cited by 46 · see citing works
The effects of brisk walking on markers of bone and calcium metabolism in postmenopausal women
Thorsen, K., Kristoffersson, A., & Lorentzon, R. (1996) · Calcified Tissue International · doi:10.1007/bf02508639 · Cited by 44 · see citing works
Self-citationCalcium homeostasis and exercise
Henderson, S., Graham, H. K., Mollan, R. A. B., et al. (1989) · International Orthopaedics · doi:10.1007/bf00266727 · Cited by 38 · see citing works
Use of a marker of collagen formation in osteoporosis studies
Risteli, J., Melkko, J., Niemi, S., et al. (1991) · Calcified Tissue International · doi:10.1007/bf02555083 · Cited by 34 · see citing works
Yamada, H., Tsutsumi, M., Fukase, M., et al. (1989) · Bone and Mineral · doi:10.1016/0169-6009(89)90022-6 · Cited by 29 · see citing works
Salvesen, H., Piehl‐Aulin, K., & Ljunghall, S. (1994) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1994.tb00424.x · Cited by 24 · see citing works
Exercise and Its Relationship to Bone Mass and Cardiovascular Function
Snow-Harter, C., Chay, C., & Marcus, R. (1994) · CPOBGYN. Clinical perspectives in obstetrics and gynecology · doi:10.1007/978-1-4612-4330-4_15 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Guillemant, J., Accarie, C., Peres, G., & Guillemant, S. (2004) · Calcified Tissue International · doi:10.1007/s00223-003-0070-0 · Cited by 134 · see citing works
Acute calcium ingestion attenuates exercise-induced disruption of calcium homeostasis
BARRY, D. W., HANSEN, K. C., VAN PELT, R. E., WITTEN, M., WOLFE, P., & KOHRT, W. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181f79fa8 · Cited by 116 · see citing works
Bouassida, A., Zalleg, D., Zaouali Ajina, M., Gharbi, N., Duclos, M., Richalet, J., & Tabka, Z. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0721-2 · Cited by 50 · see citing works
Calcium supplementation and parathyroid hormone response to vigorous walking in postmenopausal women
SHEA, K. L., BARRY, D. W., SHERK, V. D., HANSEN, K. C., WOLFE, P., & KOHRT, W. M. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000320 · Cited by 46 · see citing works
Nutritional Considerations for the Vegan Athlete
West, S., Monteyne, A. J., van der Heijden, I., Stephens, F. B., & Wall, B. T. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.012 · Cited by 42 · see citing works
Townsend, R., Elliott-Sale, K. J., Pinto, A. J., Thomas, C., Scott, J. P. R., Currell, K., Fraser, W. D., & Sale, C. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1848 · Cited by 39 · see citing works
- Authors
- Thorsen, K., Kristoffersson, A., Hultdin, J., & Lorentzon, R.
- Affiliations
- University Hospital of Umeå (SE)
- Venue
- Calcified Tissue International
- Published
- 1997-01
- Volume
- 60
- Issue
- 1
- Pages
- 16-20
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- OpenAlex
- W2039635562
- Cited by
- 90
- References
- 43
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 9 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 4 · 2012: 2
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- calcium homeostasis, parathyroid hormone, bone metabolism, C-terminal telopeptide of type I collagen, ionized calcium, young women, jogging
- MeSH terms
- Adult, Bone and Bones, Calcium, Collagen, Female, Humans, Parathyroid Hormone, Procollagen, Exercise, Osteocalcin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review