Weight changes associated with antiepileptic mood stabilizers in the treatment of bipolar disorder
Open accessAbstract
Objective To present up-to-date information and recommendations on the management of body weight changes during the use of antiepileptic mood stabilizers in bipolar disorder to help clinicians and patients make well-informed, practical decisions. Data sources Umbrella review. Systematic reviews and meta-analyses on the prevention, treatment, and monitoring of body weight changes as a side effect of the mood stabilizers valproate, lamotrigine, topiramate, and carbamazepine were identified in Embase (2010-2015, no language restrictions). Study selection The search yielded 18 relevant publications on antiepileptic mood stabilizers and weight changes in bipolar disorder. Data extraction Relevant scientific evidence was abstracted and put into a clinical perspective by a multidisciplinary expert panel of clinicians with expertise in the treatment of bipolar disorders across all age groups and a patient representative. Results Valproate has been proven to be associated with weight gain in up to 50% of its users, and can be detected 2-3 months after initiation. Carbamazepine has been proven to have a low risk of weight gain. Lamotrigine and topiramate are associated with weight loss. Other option for this sentence = Weigth gain has been proven to be associated with valproate use in up to 50% of its users, and can be detected within 2-3 months after initiation. Conclusion Each antiepileptic mood stabilizer has specific effects on body weight and accordingly requires a discrete education, prevention, monitoring, and treatment strategy. Clinicians are recommended to adopt an active, anticipatory approach, educating patients about weight change as an important side effect in order to come to informed shared decisions about the most suitable mood stabilizer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Improving fitness may offer a similarly motivating but more achievable goal for exercise interventions in people with mental illness.
“Improving fitness may offer a similarly-motivating 271 , but more achievable, 279,280 goal for exercise interventions in people with mental illness.”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [271]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488 · see citing works
Vancampfort, D., Stubbs, B., Mitchell, A. J., De Hert, M., Wampers, M., Ward, P. B., Rosenbaum, S., & Correll, C. U. (2015) · World Psychiatry · doi:10.1002/wps.20252 · Cited by 1,271 · see citing works
Yatham, L. N., Kennedy, S. H., Parikh, S. V., Schaffer, A., Beaulieu, S., Alda, M., O’Donovan, C., MacQUEEN, G. M., McIntyre, R. S., Sharma, V., et al. (2012) · Bipolar Disorders · doi:10.1111/bdi.12025 · Cited by 1,209 · see citing works
Drugs Commonly Associated With Weight Change: A Systematic Review and Meta-analysis
Domecq, J. P., Prutsky, G. J., Leppin, A. L., Sonbol, M. B., Altayar, O., Undavalli, C., Wang, Z., Elraiyah, T. A., Brito, J. P., Mauck, K. F., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3421 · Cited by 334 · see citing works
Adverse drug reactions induced by valproic acid
Nanau, R. M., & Neuman, M. G. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.06.012 · Cited by 323 · see citing works
Álvarez‐Jiménez, M., Hetrick, S. E., González‐Blanch, C., Gleeson, J., & McGorry, P. D. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.042853 · Cited by 315 · see citing works
Maayan, L. A., Vakhrusheva, J., & Correll, C. U. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.21 · Cited by 230 · see citing works
Ramasubbu, R., Taylor, V. H., Samaan, Z., Sockalingham, S., Li, M., Patten, S., Rodin, G., Schaffer, A., Beaulieu, S., & McIntyre, R. S. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400110 · Cited by 206 · see citing works
Kushner, S. F., Khan, A., Lane, R., & Olson, W. H. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00276.x · Cited by 180 · see citing works
Verrotti, A., D’Egidio, C., Mohn, A., Coppola, G., & Chiarelli, F. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00800.x · Cited by 160 · see citing works
Metabolic and endocrine effects of valproic acid chronic treatment
Belcastro, V., D’Egidio, C., Striano, P., & Verrotti, A. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2013.08.016 · Cited by 145 · see citing works
Valproate in bipolar disorder: 2000 onwards
Bowden, C. L., & Singh, V. K. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00522.x · Cited by 90 · see citing works
Topiramate add-on for drug-resistant partial epilepsy
Pulman, J., Jetté, N., Dykeman, J., Hemming, K., Hutton, J. L., & Marson, A. G. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001417.pub3 · Cited by 81 · see citing works
Weight Considerations in Psychotropic Drug Prescribing and Switching
Hasnain, M., & Vieweg, W. R. (2013) · Postgraduate medicine · doi:10.3810/pgm.2013.09.2706 · Cited by 75 · see citing works
Martínez-Ortega, J. M., Funes-Godoy, S., Díaz-Atienza, F., Gutiérrez-Rojas, L., Pérez-Costillas, L., & Gurpegui, M. (2013) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0399-5 · Cited by 72 · see citing works
The role of valproate in metabolic disturbances in bipolar disorder patients
Chang, H. H., Yang, Y. K., Gean, P. W., Huang, H. C., Chen, P. S., & Lu, R. B. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.011 · Cited by 64 · see citing works
Safety and Tolerability of Lamotrigine
Seo, H., Chiesa, A., Lee, S.-J., Patkar, A. A., Han, C., Masand, P. S., Serretti, A., & Pae, C. (2011) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3182055c07 · Cited by 64 · see citing works
Management of Adverse Effects of Mood Stabilizers
Murru, A., Popović, D., Pacchiarotti, I., Hidalgo, D., Caballero, J. L., & Vieta, E. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0603-z · Cited by 63 · see citing works
McIntyre, R. S., Alsuwaidan, M., Goldstein, B. I., Taylor, V. H., Schaffer, A., Beaulieu, S., & Kemp, D. E. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400108 · Cited by 45 · see citing works
Role of Adverse Effects in Medication Nonadherence in Bipolar Disorder
Mago, R., Borra, D., & Mahajan, R. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000017 · Cited by 29 · see citing works
Practitioner Review: Long‐term pharmacological treatment of pediatric bipolar disorder
Díaz‐Caneja, C. M., Moreno, C., Llorente, C., Espliego, A., Arango, C., & Moreno, D. M. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12271 · Cited by 27 · see citing works
Srivastava, S., & Ketter, T. A. (2011) · Clinical Therapeutics · doi:10.1016/j.clinthera.2011.11.020 · Cited by 27 · see citing works
Zuo, S., Fries, B. E., Szafara, K. L., et al. (2015) · PubMed · Cited by 23 · see citing works
Nihalani, N. D., Schwartz, T. L., Siddiqui, U. A., & Megna, J. L. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2011.00232.x · Cited by 20 · see citing works
Topiramate for Migraine Prophylaxis in Pediatric Patients
Deaton, T. L., & Mauro, L. S. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028014521128 · Cited by 13 · see citing works
Episodic Migraines in Children
Shamliyan, T., Kane, R. L., Ramakrishnan, R., & Taylor, F. R. (2013) · Journal of Child Neurology · doi:10.1177/0883073813488659 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- National Collaborating Centre for Mental health bipolar dis- order: the assessment and management of bipolar disorder in adults, children and young people in primary and secondary care; Updated edition 2014 National Institute for Health and Care Excellence (NICE)
- White W, Elmore L, Luthin DR, Cates ME (2013) Psychotropic- induced weight gain: a review of management strategies. Consultant 53(3):153-160
Cited by
Sorted by citations
Verhaegen, A. A., & Van Gaal, L. F. (2021) · Current Obesity Reports · doi:10.1007/s13679-020-00419-5 · Cited by 53 · see citing works
- Authors
- Grootens, K. P., Meijer, A., Hartong, E. G., Doornbos, B., Bakker, P. R., Al Hadithy, A., Hoogerheide, K. N., Overmeire, F., Marijnissen, R. M., & Ruhe, H. G.
- Affiliations
- Radboud University Medical Center (NL)
- University Medical Center Groningen (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- GGZ Drenthe (NL)
- Maastricht University (NL)
- Corresponding author
- Grootens, Koen P.
- Venue
- European Journal of Clinical Pharmacology
- Published
- 2018-08-07
- Volume
- 74
- Issue
- 11
- Pages
- 1485-1489
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2886780391
- Cited by
- 60
- References
- 26
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 13 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 7
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-09-14)
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, weight change, valproic acid, lamotrigine, topiramate, carbamazepine, weight gain, weight loss, adverse drug reactions, patient education, shared decision-making, weight monitoring
- MeSH terms
- Anticonvulsants, Bipolar Disorder, Body Weight, Humans, Weight Gain, Weight Loss, Antimanic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
