Serum resistin negatively correlates with clinical severity of postural tachycardia syndrome in children
Abstract
This study was designed to analyse the serum resistin level in children with postural tachycardia syndrome (POTS) and its clinical significance. Twenty-one children with POTS and 31 healthy children as controls participated in the study. Clinical characteristics, heart rate and blood pressure in the supine and upright positions were monitored and collected during an upright test, and the symptom scoring of POTS patients was recorded. The serum resistin levels of patients in both groups were determined by enzyme-linked immunosorbent assay. The change in serum resistin levels in the POTS group before and after standing, as well as its correlation with symptom scores and change in heart rate after standing, was analysed. Compared with the control group, the serum resistin levels in the POTS group were significantly increased (P 0.05). There was a negative correlation between the serum resistin levels and a change in heart rate from the supine to upright position (correlation coefficient = -0.615, P < 0.01). Moreover, serum resistin levels were negatively correlated with symptom scores (correlation coefficient = -0.493, P < 0.05). Serum resistin levels in children with POTS were significantly higher than those in healthy children and negatively correlated with a change in heart rate from the supine to upright position and symptom scores. These results suggest a protective role of increased resistin in the pathogenesis of POTS.
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Orthostatic intolerance symptoms in children with POTS have shown significant negative associations with serum resistin levels.
“and serum resistin levels (Bai et al., 2017”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Bai et al., 2017
Cites
Postural orthostatic tachycardia syndrome: the Mayo clinic experience
Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61027-6 · Cited by 516 · see citing works
Postural tachycardia syndrome (POTS)
LOW, P. A., SANDRONI, P., JOYNER, M., & SHEN, W. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01407.x · Cited by 358 · see citing works
Cardiac origins of the postural orthostatic tachycardia syndrome
Fu, Q., VanGundy, T. B., Galbreath, M. M., Shibata, S., Jain, M., Hastings, J. L., Bhella, P. S., & Levine, B. D. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.043 · Cited by 329 · see citing works
Decreased Microvascular Nitric Oxide–Dependent Vasodilation in Postural Tachycardia Syndrome
Medow, M. S., Minson, C. T., & Stewart, J. M. (2005) · Circulation · doi:10.1161/circulationaha.104.526764 · Cited by 74 · see citing works
Jordan, J., Shannon, J. R., Diedrich, A., Black, B. K., & Robertson, D. (2002) · Hypertension · doi:10.1161/hy1201.097202 · Cited by 69 · see citing works
Twenty-four-hour urinary sodium excretion and postural orthostatic tachycardia syndrome
Zhang, Q., Liao, Y., Tang, C., Du, J., & Jin, H. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.01.054 · Cited by 66 · see citing works
Self-citationWang, X.-L., Ling, T.-Y., Charlesworth, M. C., Figueroa, J. J., Low, P., Shen, W.-K., & Lee, H.-C. (2013) · Translational Research · doi:10.1016/j.trsl.2013.03.002 · Cited by 41 · see citing works
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Knoop, I., Picariello, F., Jenkinson, E., Gall, N., Chisari, C., & Moss-Morris, R. (2023) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.103052 · Cited by 21 · see citing works
“, 2012) and serum resistin levels (Bai et al., 2017).”
- Authors
- Bai, W., Han, Z., Chen, S., Li, H., Song, J., Qi, J., Liao, Y., Tang, C., Liu, P., Wang, Y., Jin, H., & Du, J.
- Affiliations
- Peking University First Hospital (CN)
- Kaifeng City Children's Hospital (CN)
- Guangdong General Hospital (CN)
- Ministry of Education of the People's Republic of China (CN)
- Corresponding author
- Jin, Hongfang
- Venue
- Pediatric Cardiology
- Published
- 2017-08-21
- Volume
- 38
- Issue
- 8
- Pages
- 1639-1644
- ISSN
- 0172-0643 (ISSN-L)
- 1432-1971
- OpenAlex
- W2749961598
- Cited by
- 8
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- resistin, postural orthostatic tachycardia syndrome, children, serum resistin levels, heart rate response to standing, symptom severity, adipokines
- MeSH terms
- Adolescent, Blood Pressure, Blood Pressure Determination, Child, Enzyme-Linked Immunosorbent Assay, Female, Heart Rate, Humans, Male, Posture, Severity of Illness Index, Tilt-Table Test, Resistin, Postural Orthostatic Tachycardia Syndrome
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