Increased Sympathetic Activation in Idiopathic Orthostatic Intolerance: Role of Systemic Adrenoreceptor Sensitivity
Abstract
Idiopathic orthostatic intolerance (OI) is characterized by adrenergic symptoms with standing. Changes in central sympathetic tone or in adrenoreceptor sensitivity could contribute to this syndrome. In OI patients and control subjects, we determined heart rate (HR) and systolic blood pressure (SBP) changes after incremental bolus doses of isoproterenol and phenylephrine before and during ganglionic blockade with trimethaphan. SBP decreased by 17+/-1.6 mm Hg in patients and 3.9+/-3.8 mm Hg in control subjects (P<0.01) with trimethaphan. Patients with a larger decrease (28+/-3.8 mm Hg, n=7) in SBP with trimethaphan had greater supine SBP and supine and upright plasma norepinephrine levels than did patients with a lesser decrease (3.0+/-3.0 mm Hg, n=7) in SBP. Supine and orthostatic HRs were similar for the groups. The majority of patients had a normal HR response to isoproterenol before and during ganglionic blockade. Phenylephrine increased SBP similarly in patients and control subjects before and during blockade. Sympathetic support is increased in a subgroup of OI patients. Hyperadrenergic and nonhyperadrenergic subgroups have similar degrees of orthostatic tachycardia. Our findings suggest that the hyperadrenergic features of OI cannot be completely explained by systemic hypersensitivity of postsynaptic alpha(1)- and beta-adrenoreceptors but rather originates in enhanced sympathetic activation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An upright plasma NE ≥600 pg/mL is the criterion most often used to define hyperadrenergic POTS, and this threshold has been adapted in recent expert consensus statements.
“An upright plasma NE ≥600 pg/mL is the criterion most often used to define hyperadrenergic POTS,4–6 and this threshold has been adapted in recent expert consensus statements.7,8”
From Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine (2024) · cites this paper as [4]
Cites
Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency
Shannon, J. R., Flattem, N. L., Jordan, J., Jacob, G., Black, B. K., Biaggioni, I., Blakely, R. D., & Robertson, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420803 · Cited by 594 · see citing works
Self-citationIdiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548 · see citing works
The neuropathic postural tachycardia syndrome
Jacob, G., Costa, F., Shannon, J. R., Robertson, R. M., Wathen, M., Stein, M., Biaggioni, I., Ertl, A., Black, B., & Robertson, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010053431404 · Cited by 398 · see citing works
Self-citationPostural tachycardia syndrome (POTS)
Lamotte, G., & Low, P. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85492-4.00118-6 · Cited by 300 · see citing works
Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans.
Goldstein, D. S., Eisenhofer, G., Stull, R., Folio, C. J., Keiser, H. R., & Kopin, I. J. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113298 · Cited by 245 · see citing works
Chronic Orthostatic Intolerance: A Disorder With Discordant Cardiac and Vascular Sympathetic Control
Furlan, R., Jacob, G., Snell, M., Robertson, D., Porta, A., Harris, P., & Mosqueda-Garcia, R. (1998) · Circulation · doi:10.1161/01.cir.98.20.2154 · Cited by 229 · see citing works
Self-citationEffects of volume loading and pressor agents in idiopathic orthostatic tachycardia
Jacob, G., Shannon, J. R., Black, B., Biaggioni, I., Mosqueda-Garcia, R., Robertson, R. M., & Robertson, D. (1997) · Circulation · doi:10.1161/01.cir.96.2.575 · Cited by 206 · see citing works
Self-citationStreeten, D. H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114878 · Cited by 170 · see citing works
Hyperdynamic Beta-Adrenergic Circulatory State
Frohlich, E. D. (1966) · Archives of Internal Medicine · doi:10.1001/archinte.1966.03870110006002 · Cited by 169 · see citing works
Patterns of plasma levels of catechols in neurogenic orthostatic hypotension
Goldstein, D. S., Polinsky, R. J., Garty, M., Robertson, D., Brown, R. T., Biaggioni, I., Stull, R., & Kopin, I. J. (1989) · Annals of Neurology · doi:10.1002/ana.410260410 · Cited by 162 · see citing works
Self-citationJacob, G., Shannon, J. R., Costa, F., Furlan, R., Biaggioni, I., Mosqueda-Garcia, R., Robertson, R. M., & Robertson, D. (1999) · Circulation · doi:10.1161/01.cir.99.13.1706 · Cited by 117 · see citing works
Self-citationHOELDTKE, R. D., & DAVIS, K. M. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-132 · Cited by 85 · see citing works
Malignant Vagotonia Due to Selective Baroreflex Failure
Jordan, J., Shannon, J. R., Black, B. K., Costa, F., Ertl, A. C., Furlan, R., Biaggioni, I., & Robertson, D. (1997) · Hypertension · doi:10.1161/01.hyp.30.5.1072 · Cited by 79 · see citing works
Self-citationWhite, M., & Leenen, F. H. H. (1994) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1994.176 · Cited by 65 · see citing works
Shannon, J. R., Jordan, J., Black, B. K., Costa, F., & Robertson, D. (1998) · Hypertension · doi:10.1161/01.hyp.32.1.101 · Cited by 65 · see citing works
Self-citationNN-Nicotinic Blockade as an Acute Human Model of Autonomic Failure
Jordan, J., Shannon, J. R., Black, B. K., Lance, R. H., Squillante, M. D., Costa, F., & Robertson, D. (1998) · Hypertension · doi:10.1161/01.hyp.31.5.1178 · Cited by 56 · see citing works
Self-citationThe physiological conundrum of hyperadrenergic orthostatic intolerance.
Jordan, J., Shannon, J., & Robertson, D. (1997) · PubMed · Cited by 16 · see citing works
Self-citationJordan, J., Shannon, J. R., Jacob, G., Pohar, B., & Robertson, D. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40642-1 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
1 of the 19 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Postural orthostatic tachycardia syndrome: the Mayo clinic experience
Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61027-6 · Cited by 516 · see citing works
Postural tachycardia syndrome (POTS)
LOW, P. A., SANDRONI, P., JOYNER, M., & SHEN, W. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01407.x · Cited by 358 · see citing works
Postural tachycardia syndrome (POTS)
Lamotte, G., & Low, P. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85492-4.00118-6 · Cited by 300 · see citing works
Autoimmune Basis for Postural Tachycardia Syndrome
Li, H., Yu, X., Liles, C., Khan, M., Vanderlinde‐Wood, M., Galloway, A., Zillner, C., Benbrook, A., Reim, S., Collier, D., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000755 · Cited by 255 · see citing works
Postural tachycardia syndrome—current experience and concepts
Mathias, C. J., Low, D. A., Iodice, V., Owens, A. P., Kirbis, M., & Grahame, R. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.187 · Cited by 251 · see citing works
Esler, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00832.2009 · Cited by 242 · see citing works
Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders
Shibao, C., Arzubiaga, C., Roberts, L. J., Raj, S., Black, B., Harris, P., & Biaggioni, I. (2005) · Hypertension · doi:10.1161/01.hyp.0000158259.68614.40 · Cited by 220 · see citing works
Self-citationAinslie, P. N., Ashmead, J. C., Ide, K., Morgan, B. J., & Poulin, M. J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.087320 · Cited by 136 · see citing works
Cardiac Sympathetic Dysautonomia in Chronic Orthostatic Intolerance Syndromes
Goldstein, D. S., Holmes, C. S., Frank, S. M., Dendi, R., Cannon, R. O., Sharabi, Y., Esler, M., & Eisenhofer, G. (2002) · Circulation · doi:10.1161/01.cir.0000036015.54619.b6 · Cited by 114 · see citing works
Fairfax, S. T., Holwerda, S. W., Credeur, D. P., Zuidema, M. Y., Medley, J. H., Dyke II, P. C., Wray, D. W., Davis, M. J., & Fadel, P. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.250894 · Cited by 108 · see citing works
Effect of aging on the cardiovascular regulatory systems in healthy women
Lavi, S., Nevo, O., Thaler, I., Rosenfeld, R., Dayan, L., Hirshoren, N., Gepstein, L., & Jacob, G. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00352.2006 · Cited by 108 · see citing works
BRADY, P. A., LOW, P. A., & SHEN, W. K. (2005) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2005.00227.x · Cited by 98 · see citing works
Lambert, E., Eikelis, N., Esler, M., Dawood, T., Schlaich, M., Bayles, R., Socratous, F., Agrotis, A., Jennings, G., Lambert, G., et al. (2008) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.107.750471 · Cited by 94 · see citing works
Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes
Okamoto, L. E., Raj, S. R., Peltier, A., Gamboa, A., Shibao, C., Diedrich, A., Black, B. K., Robertson, D., & Biaggioni, I. (2012) · Clinical Science · doi:10.1042/cs20110200 · Cited by 89 · see citing works
Self-citationA prospective, 1-year follow-up study of postural tachycardia syndrome
Kimpinski, K., Figueroa, J. J., Singer, W., Sletten, D. M., Iodice, V., Sandroni, P., Fischer, P. R., Opfer-Gehrking, T. L., Gehrking, J. A., & Low, P. A. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.02.020 · Cited by 81 · see citing works
Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome
Muenter Swift, N., Charkoudian, N., Dotson, R. M., Suarez, G. A., & Low, P. A. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01243.2004 · Cited by 70 · see citing works
24-Hour BP in Children With Congenital Central Hypoventilation Syndrome
Trang, H., Boureghda, S., Denjoy, I., Alia, M., & Kabaker, M. (2003) · CHEST Journal · doi:10.1378/chest.124.4.1393 · Cited by 58 · see citing works
Okamoto, L. E., Raj, S. R., Gamboa, A. C., Shibao, C. A., Arnold, A. C., Garland, E. M., Black, B. K., Farley, G., Diedrich, A., & Biaggioni, I. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00409.2015 · Cited by 57 · see citing works
Self-citationSympathetic Nervous System Moves Toward Center Stage in Cardiovascular Medicine
Esler, M. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02439 · Cited by 55 · see citing works
Sympathetic dysfunction in vasovagal syncope and the postural orthostatic tachycardia syndrome
Lambert, É., & Lambert, G. W. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00280 · Cited by 56 · see citing works
Syncope in Children and Adolescents
Kanjwal, K., & Calkins, H. (2015) · Cardiology Clinics · doi:10.1016/j.ccl.2015.04.008 · Cited by 52 · see citing works
Del Pozzi, A. T., Schwartz, C. E., Tewari, D., Medow, M. S., & Stewart, J. M. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02824 · Cited by 49 · see citing works
Vagal and Sympathetic Function in Neuropathic Postural Tachycardia Syndrome
Jacob, G., Diedrich, L., Sato, K., Brychta, R. J., Raj, S. R., Robertson, D., Biaggioni, I., & Diedrich, A. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.11803 · Cited by 51 · see citing works
Self-citationKanjwal, K., Saeed, B., Karabin, B., Kanjwal, Y., & Grubb, B. P. (2011) · Cardiology Journal · doi:10.5603/cj.2011.0008 · Cited by 46 · see citing works
Diagnostic management of orthostatic intolerance in the workplace
Winker, R., Barth, A., Dorner, W., Mayr, O., Pilger, A., Ivancsits, S., Ponocny, I., Heider, A., Wolf, C., & Rüdiger, H. W. (2003) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-002-0395-4 · Cited by 43 · see citing works
Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
Schroeder, C., Adams, F., Boschmann, M., Tank, J., Haertter, S., Diedrich, A., Biaggioni, I., Luft, F. C., & Jordan, J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00689.2003 · Cited by 42 · see citing works
Self-citationPostural Tachycardia Syndrome and Reflex Syncope: Similarities and Differences
Stewart, J. M. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.004 · Cited by 38 · see citing works
Foley, L. M., Hitchens, T. K., Kochanek, P. M., Melick, J. A., Jackson, E. K., & Ho, C. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20621 · Cited by 34 · see citing works
Kanjwal, K., Sheikh, M. A., Karabin, B. L., Kanjwal, Y., & Grubb, B. P. (2011) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02994.x · Cited by 33 · see citing works
Hormonal Influences on Cardiovascular Norepinephrine Transporter Responses in Healthy Women
Moldovanova, I., Schroeder, C., Jacob, G., Hiemke, C., Diedrich, A., Luft, F. C., & Jordan, J. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.107433 · Cited by 32 · see citing works
Self-citationHorowitz, R. I., & Freeman, P. (2018) · Healthcare · doi:10.3390/healthcare6040129 · Cited by 25 · see citing works
Dulal, D., Maraey, A. M., Elsharnoby, H. R., Chacko, P., & Grubb, B. P. (2025) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcae111 · Cited by 28 · see citing works
Norcliffe‐Kaufmann, L., Katz, S. D., Axelrod, F. B., & Kaufmann, H. (2015) · Annals of Neurology · doi:10.1002/ana.24377 · Cited by 26 · see citing works
Romano, S. M., Lazzeri, C., Chiostri, M., Gensini, G. F., & Franchi, F. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.046 · Cited by 23 · see citing works
Baumert, M., Lambert, É., Vaddadi, G., Sari, C. I., Esler, M., Lambert, G. W., Sanders, P., & Nalivaiko, E. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.06.017 · Cited by 21 · see citing works
Postural Tachycardia, Orthostatic Intolerance, and the Chronic Fatigue Syndrome
Grubb, B. P., Calkins, H. G., & Rowe, P. C. (2005) · Wiley eBooks · doi:10.1002/9780470994801.ch13 · Cited by 21 · see citing works
Clinical neurophysiology of postural tachycardia syndrome
Cutsforth‐Gregory, J. K., & Sandroni, P. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64142-7.00066-7 · Cited by 20 · see citing works
Stewart, J. M., Taneja, I., & Medow, M. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00439.2007 · Cited by 19 · see citing works
Postural Orthostatic Tachycardia Syndrome (POTS)
Mizumaki, K. (2011) · Journal of Arrhythmia · doi:10.1016/s1880-4276(11)80031-1 · Cited by 18 · see citing works
Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance
Winker, R., Barth, A., Valic, E., Maier, R., Osterode, W., Pilger, A., & R�diger, H. W. (2005) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-005-0605-y · Cited by 17 · see citing works
Jacob, G., Garland, E. M., da Costa, F. A. A., Stein, C. M., Xie, H., Robertson, R. M., Biaggioni, I., & Robertson, D. (2006) · Hypertension · doi:10.1161/01.hyp.0000205120.46149.34 · Cited by 17 · see citing works
Self-citationDermatological Manifestations of Postural Tachycardia Syndrome Are Common and Diverse
Huang, H., Deb, A., Culbertson, C. J., Morgenshtern, K., & Hohler, A. D. (2016) · Journal of Clinical Neurology · doi:10.3988/jcn.2016.12.1.75 · Cited by 15 · see citing works
Kanjwal, K., Karabin, B. L., Sheikh, M. A., Kanjwal, Y., & Grubb, B. P. (2010) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-010-9506-4 · Cited by 15 · see citing works
Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine
Okamoto, L. E., Urechie, V., Rigo, S., Abner, J. J., Giesecke, M., Muldowney, J. A. S., Furlan, R., Shibao, C. A., Shirey-Rice, J. K., Pulley, J. M., et al. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.23035 · Cited by 13 · see citing works
“An upright plasma NE ≥ 600 pg/mL is the criterion most often used to define hyperadrenergic POTS, 4–6 and this threshold has been adapted in recent expert consensus statements.”
InfluentialSelf-citationCutaneous alpha‐synuclein deposition in postural tachycardia patients
Levine, T. D., Bellaire, B., Gibbons, C., & Freeman, R. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51347 · Cited by 11 · see citing works
Postural Tachycardia Syndrome (POTS)
Low, P. A., & Sandroni, P. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-386525-0.00106-2 · Cited by 11 · see citing works
Influence of an Insertion Variant in the 5ʹUTR of the Endothelin-1 Gene on Orthostatic Intolerance
Winker, R., Rüdiger, H. W., Garland, E. M., Diedrich, A., Biaggioni, I., Robertson, D., Ponocny, I., & Cascorbi, I. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200510000-00003 · Cited by 11 · see citing works
Self-citationThe dermatological manifestations of postural tachycardia syndrome: a review with illustrated cases
Huang, H., & Hohler, A. D. (2015) · American Journal of Clinical Dermatology · doi:10.1007/s40257-015-0144-6 · Cited by 10 · see citing works
Lin, Y., Po, H. L., Hsu, H.-Y., Chung, C., Sheng, W., & Hu, H. (2011) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2011.06.008 · Cited by 10 · see citing works
Postural orthostatic tachycardia syndrome and general anesthesia: a series of 13 cases
Rabbitts, J. A., Groenewald, C. B., Jacob, A. K., Low, P. A., & Curry, T. B. (2011) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2010.12.013 · Cited by 11 · see citing works
Lambert, É., Eikelis, N., Esler, M., Dawood, T., Schlaich, M. P., Bayles, R., Socratous, F., Agrotis, A., Jennings, G., Lambert, G. W., et al. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.10.003 · Cited by 9 · see citing works
Bai, W., Han, Z., Chen, S., Li, H., Song, J., Qi, J., Liao, Y., Tang, C., Liu, P., Wang, Y., et al. (2017) · Pediatric Cardiology · doi:10.1007/s00246-017-1708-4 · Cited by 8 · see citing works
Diehl, R. R. (2005) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2005.00215.x · Cited by 7 · see citing works
Syncope in Children and Adolescents
Kanjwal, K., & Calkins, H. G. (2013) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2013.08.007 · Cited by 6 · see citing works
Nesheiwat, Z., Towheed, A., Eid, J., Tomcho, J. C., Shastri, P., Oostra, C., Karabin, B. L., & Grubb, B. P. (2020) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2021.120201 · Cited by 6 · see citing works
van Campen, C. M. C., Rowe, P. C., & Visser, F. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13247726 · Cited by 5 · see citing works
Kanjwal, K., Kichloo, A., Qadir, R., & Grubb, B. P. (2021) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2021.120307 · Cited by 5 · see citing works
Orthostatic Hypotension and Orthostatic Intolerance
Mathias, C. J., Iodice, V., Low, D. A., & Galizia, G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00113-x · Cited by 4 · see citing works
Shinoura, N., & Yamada, R. (2005) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.02.005 · Cited by 4 · see citing works
Spencer, E. B., Hassan, M. E., Saikia, J., Ajeya, D., Phillips, R., Steinberg, R. S., Abojaib, L., Bortfeld, K., Thadani, S., Bernstein, A., et al. (2026) · EClinicalMedicine · doi:10.1016/j.eclinm.2026.103772 · Cited by 3 · see citing works
Orthostatic Hypotension and Orthostatic Intolerance
Mathias, C. J., & Galizia, G. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00113-1 · Cited by 3 · see citing works
Evaluation of the Patient with Orthostatic Intolerance
Schondorf, R. (2004) · Elsevier eBooks · doi:10.1016/b978-012589762-4/50059-1 · Cited by 2 · see citing works
Anxiety and depression moods is involved in the pathogenesis of postural tachycardia syndrome
Li, H., Shao, W., Gao, L., Han, Z., & Xiao, Y. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.04.001 · Cited by 1 · see citing works
Differential Diagnosis of Vasovagal Syncope: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Sarzi‐Puttini, P., Batticciotto, A., Talotta, R., & Atzeni, F. (2014) · Springer eBooks · doi:10.1007/978-3-319-09102-0_16 · Cited by 1 · see citing works
Hereditary dysautonomias: current knowledge and collaborations for the future
Cuajungco, M. P., Ando, Y., Axelrod, F. B., Biaggioni, I., Goldstein, D. S., Guttmacher, A. E., Gwinn, K. A., Hahn, M. K., Hilz, M. J., Jacob, G., et al. (2003) · Clinical Autonomic Research · doi:10.1007/s10286-003-0098-2 · Cited by 1 · see citing works
Self-citationAnxiety and depression emotion is involved in the pathogenesis of postural tachycardia syndromePreprint
Shao, W., Li, H., Gao, L., Han, Z., & Yuan, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2059525/v1 · Cited by 1 · see citing works
Strempel, S. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-9269
Widesott, L., Bernardi, L., Furlan, R., Diedrich, L., Antolini, R., Nollo, G., & Diedrich, A. (2003) · Computers in cardiology · doi:10.1109/cic.2002.1166702
Self-citationIdiopathic Vagal Palsy Complicated with Orthostatic Tachycardia
Lai, Y.-H., Lin, J., & Cheng, C. (2010) · doi:10.6136/jms.2010.30(3).127
- Authors
- Jordan, J., Shannon, J. R., Diedrich, A., Black, B. K., & Robertson, D.
- Affiliations
- Vanderbilt University (US)
- From the Clinical Research Center, Franz Volhard Clinic (J.J.), Charité, Berlin, Germany; and Nathan Blaser Shy-Drager Research Program, Autonomic Dysfunction Center, Vanderbilt University (J.R.S., A.D., B.K.B., D.R.), Nashville, Tenn.
- ORCID
- Jordan, Jens
- Venue
- Hypertension
- Published
- 2002-01
- Volume
- 39
- Issue
- 1
- Pages
- 173-178
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2171662392
- Cited by
- 69
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (5u01ns033460-03)
- National Institute of Neurological Disorders and Stroke (NS 33460)
- National Center for Research Resources (RR00095)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- sympathetic activation, norepinephrine, isoproterenol, phenylephrine, orthostatic blood pressure, heart rate, alpha1-adrenoceptors, beta-adrenergic receptors, orthostatic tachycardia
- MeSH terms
- Adrenergic alpha-Agonists, Adrenergic beta-Agonists, Adult, Antihypertensive Agents, Blood Pressure, Female, Ganglionic Blockers, Humans, Hypotension, Orthostatic, Isoproterenol, Male, Middle Aged, Nitroprusside, Norepinephrine, Phenylephrine, Posture, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Sympathetic Nervous System, Tachycardia, Trimethaphan, Baroreflex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
