Cited by 187Aquaculture disease management and microbiotaZebrafish Biomedical Research ApplicationsT-cell and B-cell Immunology

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Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish

Willett, Catherine E., Cherry, Jason J., Steiner, Lisa A.·1997·Immunogenetics

DOI 10.1007/s002510050221

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Abstract

The closely linked recombination activating genes, rag1 and rag2, encode components of the recombinase involved in V(D)J recombination of the immunoglobulin and T-cell receptor genes. These genes are expressed together exclusively in immature lymphocytes and are useful markers for following the development of lymphoid tissues. We cloned the rag locus of the zebrafish Danio rerio and sequenced the open reading frames of the rag1 and rag2 genes. Although the gene organization is similar to that in other species, the rag1 gene is unusual in possessing two introns within the coding region. In another teleost, the rainbow trout, the rag1 gene is interrupted by a single intron. Introns are not present in the rag1 gene of any other species examined to date. Expression of both rag1 and rag2 begins late in embryonic development, on day 4, by northern RNA blot analysis. Expression of rag1 was detected in the adult zebrafish thymus, pronephros, mesonephros, and ovary. This pattern of expression is consistent with previous histological studies of adult teleosts, which implicate the kidney as the major site of hematopoiesis and the thymus as the major lymphocyte-containing organ.

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Authors: Willett, C. E., Cherry, J. J., & Steiner, L. A.
Affiliations: Massachusetts Institute of Technology (US)
ORCID: Willett, Catherine E.
Venue: Immunogenetics
Publisher: Springer Science and Business Media LLC
Published: 1997-04-09
Volume: 45
Issue: 6
Pages: 394-404
ISSN: 0093-7711 (ISSN-L)
1432-1211
DOI: 10.1007/s002510050221
OpenAlex: W2002832834
Cited by: 187
References: 2
Citations by year: 2026: 3 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 10 · 2013: 5 · 2012: 7
FWCI: 3.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Immunogenetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI 09072, T32AI007463, 2R01AI08054, 5T32-AI-07463, R01AI008054)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: recombination-activating genes, RAG1, RAG2, zebrafish, V(D)J recombination, immunoglobulin genes, T cell receptor genes, gene expression, lymphoid development, thymus, pronephros, mesonephros, ovary, hematopoiesis, teleosts
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, DNA-Binding Proteins, Gene Expression Regulation, Molecular Sequence Data, Proteins, Recombination, Genetic, Zebrafish, Sequence Alignment, Homeodomain Proteins

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Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish

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