Cited by 419Zebrafish Biomedical Research ApplicationsHematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis

Davidson, Alan J, Zon, Leonard I·2004·Oncogene

Abstract

Progressive advances using zebrafish as a model organism have provided hematologists with an additional genetic system to study blood cell formation and hematological malignancies. Despite extensive evolutionary divergence between bony fish (teleosts) and mammals, the molecular pathways governing hematopoiesis have been highly conserved. As a result, most (if not all) of the critical hematopoietic transcription factor genes identified in mammals have orthologues in zebrafish. As in other vertebrates, all of the teleost blood lineages are believed to originate from a pool of pluripotent, self-renewing hematopoietic stem cells. Here, we provide a detailed review of the timing, anatomical location, and transcriptional regulation of zebrafish 'primitive' and 'definitive' hematopoiesis as well as discuss a model of T-cell leukemia and recent advances in blood cell transplantation. Given that many of the regulatory genes that control embryonic hematopoiesis have been implicated in oncogenic pathways in adults, an understanding of blood cell ontogeny is likely to provide insights into the pathophysiology of human leukemias.

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Crossref · 10.1038/sj.onc.1207943

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Authors
Davidson, A. J., & Zon, L. I.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Zon, Leonard I
Venue
Oncogene
Published
2004-09-20
Volume
23
Issue
43
Pages
7233-7246
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
OpenAlex
W2032417286
Cited by
419
References
108
Citations by year
2026: 8 · 2025: 11 · 2024: 19 · 2023: 12 · 2022: 21 · 2021: 18 · 2020: 18 · 2019: 20 · 2018: 25 · 2017: 24 · 2016: 26 · 2015: 16 · 2014: 25 · 2013: 17 · 2012: 21
FWCI
1.14
Type
journal article
Language
en
Open access
closed
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
definitive hematopoiesis, primitive hematopoiesis, hematopoietic stem cells, hematopoietic transcription factors, orthologs, T-cell leukemia, hematologic malignancies, leukemogenesis
MeSH terms
Animals, Blood Cells, Embryo, Nonmammalian, Forecasting, Gastrula, Genetic Complementation Test, Growth Substances, Hematopoiesis, Hematopoietic Stem Cells, Leukemia, Mesoderm, Radiation Chimera, Transcription Factors, Transcription, Genetic, Zebrafish, Mutagenesis, Hematopoietic Stem Cell Transplantation, Gene Expression Regulation, Developmental, Cell Lineage, Models, Animal, Zebrafish Proteins, Animals, Genetically Modified, Pluripotent Stem Cells

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