The DOI matches its Crossref record; 101 of the 102 references it cites were found in a registry or an index.
Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug
Open accessAbstract
Artemisinin isolated from the aerial parts of Artemisia annua L. is a promising and potent antimalarial drug which has a remarkable activity against chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, and is useful in treatment of cerebral malaria. Because the low content (0.01-1 %) of artemisinin in A. annua is a limitation to the commercial production of the drug, many research groups have been focusing their researches on enhancing the production of artemisinin in tissue culture or in the whole plant of A. annua. This review mainly focuses on the progresses made in the production of artemisinin from A. annua by biotechnological strategies including in vitro tissue culture, metabolic regulation of artemisinin biosynthesis, genetic engineering, and bioreactor technology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The phytomolecule artemisinin, a sesquiterpene lactone characterized by the presence of an endoperoxide bridge (Luo and Shen 1987) is very effective against chloroquine resistant strains of P. falciparum malaria (Enserink 2005; Liu et al. 2006).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Liu et al. 2006
Citations
Cites
Qinghaosu (Artemisinin): an Antimalarial Drug from China
Klayman, D. L. (1985) · Science · doi:10.1126/science.3887571 · Cited by 2,207
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003) · Nature Biotechnology · doi:10.1038/nbt833 · Cited by 1,720
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67176-0 · Cited by 1,050
Artemisinins target the SERCA of Plasmodium falciparum
Eckstein‐Ludwig, U., Webb, R. J., van Goethem, I. D. A., East, J. M., Lee, A. G., Kimura, M., O’Neill, P. M., Bray, P. G., Ward, S. A., & Krishna, S. (2003) · Nature · doi:10.1038/nature01813 · Cited by 1,043
Identification of an antimalarial synthetic trioxolane drug development candidate
Vennerstrom, J. L., Arbe‐Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., et al. (2004) · Nature · doi:10.1038/nature02779 · Cited by 632
(1994) · Medical Entomology and Zoology · Cited by 615
T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin biosynthesis.
Akiyoshi, D. E., Klee, H. J., Amasino, R. M., Nester, E. W., & Gordon, M. P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.5994 · Cited by 513
Enzymic formation of sesquiterpenes
Cane, D. E. (1990) · Chemical Reviews · doi:10.1021/cr00105a002 · Cited by 463
Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., & Covello, P. S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.065 · Cited by 409
Automation and environmental control in plant tissue culture
Aitken-Christie, J., Kozai, T., & Lila, M. A. (1995) · Springer eBooks · doi:10.1007/978-94-015-8461-6 · Cited by 347
Research works printed but not linked: 7
- Geng S, Ye HC, Li GF (2001a) Flowering of Artemisia annua L. test-tube plantlets and artemisinin production with shoot cultures induced from flower organ explants. Chin Appl Environ Biol 7:201–206
- Guo C, Liu CZ, Ye HC, Li GF (2004) Effect of temperature on growth and artemisinin biosynthesis in hairy root cultures of Artemisia annua. Acta Bot Boreal-Occident Sin 24:1828–1831
- Liu BY, Ye HC, Li GF (1998a) Studies on dynamic of growth and artemisinin biosynthesis of hairy root of Artemisia annua L. Chin J Biotechnol 14:401–404
- Qinghaosu Antimalaria Coordinating Research Group (1979) Antimalaria studies on qinghaosu. Chin Med J (Engl) 92:811–816
- Teo CKH, Yap AW, Chan KL, Gan EK, Tanaka M (1995) Artemisinin production from callus of Artemisia annua cultured in fluorocarbon polymer film culture bag. Asia-Pac J Mol Biol Biotechnol 3:317–321
- Wang CW (1961) The forest of China with a survey of grassland and desert vegetation In: Harvard University Maria moors cabot foundation, vol 5. Harvard University, Cambridge, MA, pp 171–187
- Whipkey A, Simon JE, Charles DJ, Janick J (1992) In vitro production of artemisinin from Artemisia annua L. Phytother Res 1:15–25
Cited by
Sorted by citations
Pan, S.-Y., Zhou, S.-F., Gao, S.-H., Yu, Z., Zhang, S.-F., Tang, M.-K., Sun, J.-N., Ma, D., Han, Y., Fong, W. F., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/627375 · Cited by 750
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
Corson, T. W., & Crews, C. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.021 · Cited by 656
Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms
Ajikumar, P. K., Tyo, K. E. J., Carlsen, S., Mucha, O., Too, H., & Stephanopoulos, G. N. (2008) · Molecular Pharmaceutics · doi:10.1021/mp700151b · Cited by 451
Genome Sequence of Babesia bovis and Comparative Analysis of Apicomplexan Hemoprotozoa
Brayton, K. A., Lau, A. O. T., Herndon, D. R., Hannick, L. I., Kappmeyer, L. S., Berens, S. J., Bidwell, S. L., Brown, W. C., Crabtree, J., Fadrosh, D., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030148 · Cited by 401
Production and engineering of terpenoids in plant cell culture
Roberts, S. C. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.8 · Cited by 377
Metadata
- Authors
- Liu, C., Zhao, Y., & Wang, Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Liu, Chunzhao
- Wang, Yuchun
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2006-06-03
- Volume
- 72
- Issue
- 1
- Pages
- 11-20
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W2051710000
- Cited by
- 158
- References
- 102
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 16 · 2012: 8
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- green
- ir.ipe.ac.cn
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (tdm)
- Locations
- Applied Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Institute of Process Engineering, CAS Institutional Repository (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Keywords
- artemisinin, Artemisia annua, antimalarial drugs, Plasmodium falciparum, chloroquine resistance, cerebral malaria, artemisinin biosynthesis, metabolic engineering, genetic engineering, in vitro tissue culture, bioreactors, plant secondary metabolites
- MeSH terms
- Antimalarials, Biotechnology, Fermentation, Sesquiterpenes, Technology, Pharmaceutical, Cell Culture Techniques, Bioreactors, Artemisia annua, Artemisinins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
