Cited by 158Plant tissue culture and regenerationPlant biochemistry and biosynthesisSesquiterpenes and Asteraceae Studies

The DOI matches its Crossref record; 101 of the 102 references it cites were found in a registry or an index.

Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

Open access

Liu, Chunzhao, Zhao, Yan, Wang, Yuchun·2006·Applied Microbiology and Biotechnology

DOI 10.1007/s00253-006-0452-0

Open this paper in CoChat — free account

Abstract

Artemisinin isolated from the aerial parts of Artemisia annua L. is a promising and potent antimalarial drug which has a remarkable activity against chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, and is useful in treatment of cerebral malaria. Because the low content (0.01-1 %) of artemisinin in A. annua is a limitation to the commercial production of the drug, many research groups have been focusing their researches on enhancing the production of artemisinin in tissue culture or in the whole plant of A. annua. This review mainly focuses on the progresses made in the production of artemisinin from A. annua by biotechnological strategies including in vitro tissue culture, metabolic regulation of artemisinin biosynthesis, genetic engineering, and bioreactor technology.

Integrity signals

Registry

Crossref · 10.1007/s00253-006-0452-0

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Qinghaosu (Artemisinin): an Antimalarial Drug from China
Klayman, D. L. (1985) · Science · doi:10.1126/science.3887571 · Cited by 2,207
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003) · Nature Biotechnology · doi:10.1038/nbt833 · Cited by 1,720
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67176-0 · Cited by 1,050
Artemisinins target the SERCA of Plasmodium falciparum
Eckstein‐Ludwig, U., Webb, R. J., van Goethem, I. D. A., East, J. M., Lee, A. G., Kimura, M., O’Neill, P. M., Bray, P. G., Ward, S. A., & Krishna, S. (2003) · Nature · doi:10.1038/nature01813 · Cited by 1,043
Identification of an antimalarial synthetic trioxolane drug development candidate
Vennerstrom, J. L., Arbe‐Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., et al. (2004) · Nature · doi:10.1038/nature02779 · Cited by 632
Untitled work
(1994) · Medical Entomology and Zoology · Cited by 615
T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin biosynthesis.
Akiyoshi, D. E., Klee, H. J., Amasino, R. M., Nester, E. W., & Gordon, M. P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.5994 · Cited by 513
Enzymic formation of sesquiterpenes
Cane, D. E. (1990) · Chemical Reviews · doi:10.1021/cr00105a002 · Cited by 463
Artemisia annua L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin
Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., & Covello, P. S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.065 · Cited by 409
Automation and environmental control in plant tissue culture
Aitken-Christie, J., Kozai, T., & Lila, M. A. (1995) · Springer eBooks · doi:10.1007/978-94-015-8461-6 · Cited by 347

Show all 102 references

Research works printed but not linked: 7

Geng S, Ye HC, Li GF (2001a) Flowering of Artemisia annua L. test-tube plantlets and artemisinin production with shoot cultures induced from flower organ explants. Chin Appl Environ Biol 7:201–206
Guo C, Liu CZ, Ye HC, Li GF (2004) Effect of temperature on growth and artemisinin biosynthesis in hairy root cultures of Artemisia annua. Acta Bot Boreal-Occident Sin 24:1828–1831
Liu BY, Ye HC, Li GF (1998a) Studies on dynamic of growth and artemisinin biosynthesis of hairy root of Artemisia annua L. Chin J Biotechnol 14:401–404
Qinghaosu Antimalaria Coordinating Research Group (1979) Antimalaria studies on qinghaosu. Chin Med J (Engl) 92:811–816
Teo CKH, Yap AW, Chan KL, Gan EK, Tanaka M (1995) Artemisinin production from callus of Artemisia annua cultured in fluorocarbon polymer film culture bag. Asia-Pac J Mol Biol Biotechnol 3:317–321
Wang CW (1961) The forest of China with a survey of grassland and desert vegetation In: Harvard University Maria moors cabot foundation, vol 5. Harvard University, Cambridge, MA, pp 171–187
Whipkey A, Simon JE, Charles DJ, Janick J (1992) In vitro production of artemisinin from Artemisia annua L. Phytother Res 1:15–25

Sorted by citations

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics
Pan, S.-Y., Zhou, S.-F., Gao, S.-H., Yu, Z., Zhang, S.-F., Tang, M.-K., Sun, J.-N., Ma, D., Han, Y., Fong, W. F., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/627375 · Cited by 750
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
Corson, T. W., & Crews, C. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.021 · Cited by 656
Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms
Ajikumar, P. K., Tyo, K. E. J., Carlsen, S., Mucha, O., Too, H., & Stephanopoulos, G. N. (2008) · Molecular Pharmaceutics · doi:10.1021/mp700151b · Cited by 451
Genome Sequence of Babesia bovis and Comparative Analysis of Apicomplexan Hemoprotozoa
Brayton, K. A., Lau, A. O. T., Herndon, D. R., Hannick, L. I., Kappmeyer, L. S., Berens, S. J., Bidwell, S. L., Brown, W. C., Crabtree, J., Fadrosh, D., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030148 · Cited by 401
Production and engineering of terpenoids in plant cell culture
Roberts, S. C. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.8 · Cited by 377
The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363
Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules
Wilson, S., & Roberts, S. C. (2011) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00664.x · Cited by 359
Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis
Zhao, L., Chang, W., Xiao, Y., Liu, H., & Liu, P. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052010-100934 · Cited by 365
Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology
Kolewe, M. E., Gaurav, V., & Roberts, S. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp7001494 · Cited by 294
21st Century natural product research and drug development and traditional medicines
Ngô, L., Okogun, J. I., & Folk, W. R. (2013) · Natural Product Reports · doi:10.1039/c3np20120a · Cited by 254
Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti‐malarial drug, by hairpin‐RNA‐mediated gene silencing
Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., & Tang, K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080068 · Cited by 206
Self-citation
Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae
Sun, J., Shao, Z., Zhao, H., Nair, N. U., Wen, F., Xu, J., & Zhao, H. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24481 · Cited by 186
Applications of synthetic biology in medical and pharmaceutical fields
Yan, X., Liu, X., Zhao, C., & Chen, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01440-5 · Cited by 191
Artemisia afra: A potential flagship for African medicinal plants?
Liu, N. Q., van der Kooy, F., & Verpoorte, R. (2008) · South African Journal of Botany · doi:10.1016/j.sajb.2008.11.001 · Cited by 145
Artemisia annua as a self-reliant treatment for malaria in developing countries
de Ridder, S., van der Kooy, F., & Verpoorte, R. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.09.017 · Cited by 141
Light-induced biochemical variations in secondary metabolite production and antioxidant activity in callus cultures of Stevia rebaudiana (Bert)
Ahmad, N., Rab, A., & Ahmad, N. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.11.015 · Cited by 140
Current progress in the study on biosynthesis and regulation of ganoderic acids
Shi, L., Ren, A., Mu, D., & Zhao, M. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2871-1 · Cited by 132
Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway
Jing, F., Zhang, L., Li, M., Tang, Y., Wang, Y., Wang, Y., Wang, Q., Pan, Q., Wang, G., & Tang, K. (2009) · Biologia · doi:10.2478/s11756-009-0040-8 · Cited by 123
Self-citation
Comparative Effects of Different Light Sources on the Production of Key Secondary Metabolites in Plants In Vitro Cultures
Hashim, M., Ahmad, B., Drouet, S., Hano, C., Abbasi, B. H., & Anjum, S. (2021) · Plants · doi:10.3390/plants10081521 · Cited by 123
UV-B and UV-C pre-treatments induce physiological changes and artemisinin biosynthesis in Artemisia annua L. – An antimalarial plant
Rai, R., Meena, R. P., Smita, S. S., Shukla, A., Kumar, S., & Rai, S. P. (2011) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2011.09.004 · Cited by 116
Regulation of cell fate determination by single-repeat R3 MYB transcription factors in Arabidopsis
Wang, S., & Chen, J. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00133 · Cited by 112
Comparison of the effects of Artemisia vulgaris and Artemisia absinthium growing in western Anatolia against trichinellosis (Trichinella spiralis) in rats
Caner, A., Döşkaya, M., Döşkaya, A. D., Can, H., Baykan, Ş., Üner, A., Başdemir, G., Zeybek, U., & Gürüz, Y. (2008) · Experimental Parasitology · doi:10.1016/j.exppara.2008.01.012 · Cited by 98
Light-induced fluctuations in biomass accumulation, secondary metabolites production and antioxidant activity in cell suspension cultures of Artemisia absinthium L.
Ali, M., & Abbasi, B. H. (2014) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2014.08.008 · Cited by 94
Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco
Shangguan, X., Xu, B., Yu, Z.-X., Wang, L.-J., & Chen, X. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern204 · Cited by 93
Metabolic engineering of microorganisms for isoprenoid production
Kirby, J., & Keasling, J. D. (2008) · Natural Product Reports · doi:10.1039/b802939c · Cited by 91
Discovery of New Biocatalysts for the Glycosylation of Terpenoid Scaffolds
Caputi, L., Lim, E., & Bowles, D. J. (2008) · Chemistry - A European Journal · doi:10.1002/chem.200800548 · Cited by 90
In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species
Ramazani, A., Sardari, S., Zakeri, S., & Vaziri, B. (2010) · Parasitology Research · doi:10.1007/s00436-010-1900-4 · Cited by 78
Modulation of artemisinin biosynthesis by elicitors, inhibitor, and precursor in hairy root cultures of Artemisia annua L.
Ahlawat, S., Saxena, P., Alam, P., Wajid, S., & Abdin, M. Z. (2014) · Journal of Plant Interactions · doi:10.1080/17429145.2014.949885 · Cited by 78
Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches
Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74
Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies
Rayia, D. M. A., Saad, A. E., Ashour, D. S., & Oreiby, R. M. (2016) · Parasitology International · doi:10.1016/j.parint.2016.11.012 · Cited by 76
Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets
Ding, X. C., Beck, H., & Raso, G. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2010.11.006 · Cited by 74
Asteraceae species as potential environmental factors of allergy
Denisow‐Pietrzyk, M., Pietrzyk, Ł., & Denisow, B. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-04146-w · Cited by 70
Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity
Galal, A. M., Gul, W., Slade, D., Ross, S. A., Feng, S., Hollingshead, M. G., Alley, M. C., Kaur, G., & ElSohly, M. A. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.11.050 · Cited by 69
Lights triggered differential accumulation of antioxidant and antidiabetic secondary metabolites in callus culture of Eclipta alba L.
Khurshid, R., Ullah, M. A., Tungmunnithum, D., Drouet, S., Shah, M., Zaeem, A., Hameed, S., Hano, C., & Abbasi, B. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233963 · Cited by 69
Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro
Bhattacharya, A., Mishra, L. C., Sharma, M., Awasthi, S. K., & Bhasin, V. K. (2009) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2009.02.008 · Cited by 66
The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives
van der Kooy, F., & Sullivan, S. E. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.08.021 · Cited by 66
Chinese Medicine in the Battle Against Obesity and Metabolic Diseases
Xu, L., Zhao, W., Wang, D., & Ma, X. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00850 · Cited by 65
Microbial Production of Isoprenoids Enabled by Synthetic Biology
Immethun, C. M., Hoynes-O’Connor, A., Balassy, A., & Moon, T. S. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00075 · Cited by 61
Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method
Zou, R., Zhou, K., Stephanopoulos, G. N., & Too, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079557 · Cited by 61
Alkylating enzymes
Wessjohann, L. A., Keim, J., Weigel, B., & Dippe, M. (2013) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2013.02.016 · Cited by 60
Exogenous Strigolactone (GR24) Positively Regulates Growth, Photosynthesis, and Improves Glandular Trichome Attributes for Enhanced Artemisinin Production in Artemisia annua
Wani, K. I., Zehra, A., Choudhary, S., Naeem, M., Khan, M. M. A., Khan, R., & Aftab, T. (2022) · Journal of Plant Growth Regulation · doi:10.1007/s00344-022-10654-w · Cited by 61
Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
Muangphrom, P., Seki, H., Fukushima, E. O., & Muranaka, T. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1008-y · Cited by 63
Artemisinin production by plant hairy root cultures in gas- and liquid-phase bioreactors
Patra, N., & Srivastava, A. K. (2015) · Plant Cell Reports · doi:10.1007/s00299-015-1875-9 · Cited by 58
Synergistic effects of melatonin and distinct spectral lights for enhanced production of anti-cancerous compounds in callus cultures of Fagonia indica
Khan, T., Ullah, M. A., Garros, L., Hano, C., & Abbasi, B. H. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.10.010 · Cited by 58
Strategies on biosynthesis and production of bioactive compounds in medicinal plants
Guo, M., Lv, H., Chen, H., Dong, S., Zhang, J., Liu, W., He, L., Ma, Y., Yu, H., Chen, S., et al. (2023) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2023.01.007 · Cited by 60
Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts
Muntendam, R., Melillo, E., Rydén, A., & Kayser, O. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2150-1 · Cited by 57
Schisandra lignans production regulated by different bioreactor type
Szopa, A., Kokotkiewicz, A., Łuczkiewicz, M., & Ekiert, H. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.02.007 · Cited by 54
Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from Artemisia annua L.
Al-Khayri, J. M., Sudheer, W. N., Lakshmaiah, V. V., Mukherjee, E., Nizam, A., Thiruvengadam, M., Nagella, P., Alessa, F. M., Al-Mssallem, M. Q., Adel Abdel-Sabour, R. E. Z. K., et al. (2022) · Molecules · doi:10.3390/molecules27093040 · Cited by 54
β-Cyclodextrins enhance artemisinin production in Artemisia annua suspension cell cultures
Durante, M., Caretto, S., Quarta, A., Paolis, A. D., Nisi, R., & Mita, G. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3232-4 · Cited by 51
Cambial meristematic cells: a platform for the production of plant natural products
Ochoa-Villarreal, M., Howat, S., Jang, M. O., Kim, I. S., Jin, Y.-W., Lee, E.-K., & Loake, G. J. (2015) · New Biotechnology · doi:10.1016/j.nbt.2015.02.003 · Cited by 52
Selection and Clonal Propagation of High Artemisinin Genotypes of Artemisia annua
Wetzstein, H. Y., Porter, J. A., Janick, J., Ferreira, J. F. S., & Mutui, T. M. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00358 · Cited by 49
Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production
Pandey, N., & Rai, S. P. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0805-6 · Cited by 48
Medicinal plants for in vitro antiplasmodial activities: A systematic review of literature
Lemma, M. T., Ahmed, A. M., Elhady, M. T., Ngo, H. T., Vu, T. L.-H., Sang, T. K., Campos‐Alberto, E., Sayed, A., Mizukami, S., Na‐Bangchang, K., et al. (2017) · Parasitology International · doi:10.1016/j.parint.2017.09.002 · Cited by 45
Comparison of Artemisia annua Bioactivities between Traditional Medicine and Chemical Extracts
Nageeb, A., Al-Tawashi, A., Emwas, A.-H. M., Al‐Talla, Z. A., & Al-Rifai, N. (2014) · Current Bioactive Compounds · doi:10.2174/157340720904140404151439 · Cited by 43
Bioreactor type affects the accumulation of phenolic acids and flavonoids in microshoot cultures of Schisandra chinensis (Turcz.) Baill.
Szopa, A., Kokotkiewicz, A., Bednarz, M., Jafernik, K., Łuczkiewicz, M., & Ekiert, H. (2019) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-019-01676-6 · Cited by 42
Hairy roots induction and artemisinin analysis in Artemisia dubia and Artemisia indica
Mannan, A., Shaheen, N., Arshad, W., Qureshi, R. A., Zia, M., & Mirza, B. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i18.59272 · Cited by 41
Inhibition of tumor cell proliferation and induction of apoptosis in human lung carcinoma 95-D cells by a new sesquiterpene from hairy root cultures of Artemisia annua
Zhai, D. D., Supaibulwatana, K., & Zhong, J. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.02.008 · Cited by 40
A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f.
Song, Y., Chen, S., Wang, X., Zhang, R., Tu, L., Hu, T., Liu, X., Zhang, Y., Huang, L., & Gao, W. (2019) · Plant Methods · doi:10.1186/s13007-019-0513-x · Cited by 39
Biotechnological approaches for artemisinin production in Artemisia
Kayani, W. K., Kiani, B. H., Dilshad, E., & Mirza, B. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2432-9 · Cited by 37
Differentially Expressed Genes during Contrasting Growth Stages of Artemisia annua for Artemisinin Content
Nair, P., Misra, A., Singh, A., Shukla, A. K., Gupta, M. M., Gupta, A. K., Gupta, V., Khanuja, S. P. S., & Shasany, A. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060375 · Cited by 38
Exogenous hydrogen sulphide alleviates copper stress impacts in Artemisia annua L.: Growth, antioxidant metabolism, glandular trichome development and artemisinin biosynthesis
Nomani, L., Zehra, A., Choudhary, S., Wani, K. I., Naeem, M., Siddiqui, M. H., Khan, M. M. A., & Aftab, T. (2021) · Plant Biology · doi:10.1111/plb.13242 · Cited by 34
Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts
Nahrevanian, H., Milan, B. S., Kazemi, M., Hajhosseini, R., Mashhadi, S. S., & Nahrevanian, S. (2012) · Malaria Research and Treatment · doi:10.1155/2012/727032 · Cited by 32
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
Alejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011) · Planta · doi:10.1007/s00425-011-1430-z · Cited by 31
Volatile fingerprints of artemisinin‐rich Artemisia annua cultivars by headspace solid‐phase microextraction gas chromatography/mass spectrometry
Reale, S., Fasciani, P., Pace, L. G., Angelis, F. D., & Marcozzi, G. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5155 · Cited by 32
Spectral lights trigger biomass accumulation and production of antioxidant secondary metabolites in adventitious root cultures of Stevia rebaudiana (Bert.)
Idrees, M., Sania, B., Hafsa, B., Kumari, S., Khan, H., Fazal, H., Ahmad, I., Akbar, F., Ahmad, N., Ali, S., et al. (2018) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2018.05.003 · Cited by 31
Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L.
Wang, Y., Yang, K., Jing, F., Li, M., Deng, T., Huang, R.-Z., Wang, B., Wang, G., Sun, X., & Tang, K. (2011) · Molecular Biology · doi:10.1134/s0026893311040145 · Cited by 28
Self-citation
In Vitro Evaluation of Achillea Millefolium on the Production and Stimulation of Human Skin Fibroblast Cells (HFS-PI-16)
Ghobadian, Z., Ahmadi, M. R. H., Rezazadeh, L., Hosseini, E., Kokhazadeh, T., & Ghavam, S. (2015) · Medical Archives · doi:10.5455/medarh.2015.69.212-217 · Cited by 26
Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.
Li, L., Brinckmann, J. A., Liu, B., Zheng, S., Huang, L., & Chen, S. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01225 · Cited by 26
Genetic engineering of artemisinin biosynthesis: prospects to improve its production
Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25
Patterns and dynamics of genetic diversity in Plasmodium falciparum: What past human migrations tell us about malaria
Mita, T., & Jombart, T. (2014) · Parasitology International · doi:10.1016/j.parint.2014.09.007 · Cited by 25
Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin
Kong, J., Yang, Y., Wang, W., Cheng, K.-D., & Zhu, P. (2013) · RSC Advances · doi:10.1039/c3ra40525g · Cited by 25
Iron oxide nanoparticles (Fe3O4-NPs) elicited Artemisia annua L. in vitro, toward enhancing artemisinin production through overexpression of key genes in the terpenoids biosynthetic pathway and induction of oxidative stress
Ayoobi, A., Saboora, A., Asgarani, E., & Efferth, T. (2024) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-024-02705-9 · Cited by 23
Searching for Artemisinin Production Improvement in Plants and Microorganisms
Barbacka, K., & Baer‐Dubowska, W. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111798376923 · Cited by 22
Recent advances in plant biotechnology and genetic engineering for production of secondary metabolites
Sheludko, Y. V. (2010) · Cytology and Genetics · doi:10.3103/s009545271001010x · Cited by 22
Comparative artemisinin analysis in Artemisia dubia transformed with two different Agrobacteria harbouring rol ABC genes.
Kiani, B. H., Safdar, N., Mannan, A., & Mirza, B. (2012) · Plant Omics · Cited by 22
Cumulative role of bioinoculants on growth, antioxidant potential and artemisinin content in Artemisia annua L. under organic field conditions
Gupta, R., Singh, A., Gupta, M. M., & Pandey, R. (2016) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-016-2130-4 · Cited by 21
Regeneration and chemical profiling in Hemidesmus indicus (L.) R. Br.
Pathak, A. R., Joshi, A., Shrivastava, N., & Sharma, P. (2017) · South African Journal of Botany · doi:10.1016/j.sajb.2017.09.022 · Cited by 21
A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu
Li, Y., & Wu, Y. (2010) · Frontiers of Chemistry in China · doi:10.1007/s11458-010-0214-5 · Cited by 20
Production and Genetic Engineering of Terpenoids Production in Plant Cell and Organ Cultures
Bonfill, M., Malik, S., Mirjalili, M. H., Goleniowski, M. E., Cusido, R. M., & Palazón, J. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_123 · Cited by 19
The rise to prominence of Artemisia annual the transformation of a Chinese plant to a global pharmaceutical
zu Biesen, C. M. (2010) · African Sociological Review / Revue Africaine de Sociologie · doi:10.4314/asr.v14i2.70234 · Cited by 19
Influence of abiotic elicitors on improvement production of artemisinin in cell culture of Artemisia annua L.
Zebarjadi, A., Dianatkhah, S., Pour Mohammadi, P., & Qaderi, A. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2018.64.9.1 · Cited by 17
Effects of exogenous methyl jasmonate and 2-isopentenyladenine on artemisinin production and gene expression in Artemisia annua
Mehrjerdi, M. Z., Bihamta, M. R., Omidi, M., Naghavi, M. R., Soltanloo, H., & Ranjbar, M. (2013) · TURKISH JOURNAL OF BOTANY · doi:10.3906/bot-1206-12 · Cited by 17
Production of Pharmaceuticals by Plant Tissue Cultures
Muranaka, T., & Saito, K. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00065-4 · Cited by 17
In Vivo Antimalarial Effects of Iranian Flora Artemisia khorassanica against Plasmodium berghei and Pharmacochemistry of its Natural Components.
Nahrevanian, H., Esmaeili, B., Kazemi, M., Nazem, H., & Amini, M. (2010) · Europe PMC (PubMed Central) · Cited by 17
Characterization of the Promoter of Artemisia annua Amorpha-4,11-diene Synthase (ADS) Gene Using Homologous and Heterologous Expression as well as Deletion Analysis
Zhu, M., Zhang, F., Lv, Z., Shen, Q., Zhang, L., Lu, X., Jiang, W., Fu, X., Yan, T., Chen, L., et al. (2013) · Plant Molecular Biology Reporter · doi:10.1007/s11105-013-0656-2 · Cited by 16
A Microbial Transformation Model for Simulating Mammal Metabolism of Artemisinin
Ma, Y., Sun, P., Zhao, Y., Wang, K., Chang, X., Bai, Y., Zhang, D., & Yang, L. (2019) · Molecules · doi:10.3390/molecules24020315 · Cited by 16
Self-citation
Characterization of santalene synthases using an inorganic pyrophosphatase coupled colorimetric assay
Hua, G., Hu, Y., Yang, C., Liu, D., Mao, Z., Zhang, L., & Zhang, Y. (2018) · Analytical Biochemistry · doi:10.1016/j.ab.2018.02.002 · Cited by 14
Influence of Agrobacterium rhizogenes on induction of hairy roots for enhanced production of artemisinin in Artemisia annua L. plants
Ahlawat, S. (2012) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb12.057 · Cited by 14
Synthesis of Silver Nanoparticles from Artemisia sieberiand Calotropis procera Medical Plant Extracts and their Characterization using SEM Analysis
Alkammash, N. M. (2017) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/2474 · Cited by 14
In vitro regeneration of gamma irradiated callus of artemisia annua and evaluation of increase artemisinin content by HPLC analysis
Patil, A. S. (2018) · Journal of Analytical & Pharmaceutical Research · doi:10.15406/japlr.2018.07.00284 · Cited by 14
New perspectives of the Artemisia annua bioactive compounds as an affordable cure in treatment of malaria and cancer
Kumar, S., Apoorva, Rai, K. K., & Rai, S. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820655-3.00015-x · Cited by 14
Bioconversion of Artemisinin to its Nonperoxidic Derivative Deoxyartemisinin through Suspension Cultures of Withania somnifera Dunal
Sabir, F., Kumar, A., Tiwari, P., Pathak, N., Sangwan, R. S., Bhakuni, R. S., & Sangwan, N. S. (2010) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2010-9-1013 · Cited by 13
Antioxidant properties of extracts from selected plant materials (Caesalpinia spinosa, Perilla frutescens, Artemisia annua and Viola wittrockiana) in vitro and in model food systems
Skowyra, M. (2014) · doi:10.5821/dissertation-2117-95555 · Cited by 13
Developmental variation during seed germination and biochemical responses of Brassica rapa exposed to various colored lights
Nawaz, T., Ahmad, N., Ali, S., Khan, M., Fazal, H., & Khalil, S. A. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.01.008 · Cited by 12
Influence of Plant Growth Regulators and Artificial Light on the Growth and Accumulation of Inulin of Dedifferentiated Chicory (Cichorium intybus L.) Callus Cells
Kirakosyan, R. N., Sumin, A. V., Polupanova, A. A., Pankova, M. G., Degtyareva, I. S., Sleptsov, N. N., & Khuat, Q. V. (2022) · Life · doi:10.3390/life12101524 · Cited by 11
Hairy root mediated functional derivatization of artemisinin and their bioactivity analysis
Pandey, P., Singh, S., Tewari, N., Srinivas, K. V. N. S., Shukla, A., Gupta, N., Vasudev, P. G., Khan, F., Pal, A., Bhakuni, R. S., et al. (2015) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2015.01.007 · Cited by 11
Bioreactor-Grown Shoot Cultures for the Secondary Metabolite Production
Król, A., Kokotkiewicz, A., Szopa, A., Ekiert, H., & Łuczkiewicz, M. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-30185-9_34 · Cited by 11
A new sesquiterpene from hairy root culture of Artemisia annua
Zhai, D. D., Jin, H. Z., & Zhong, J. (2010) · Chinese Chemical Letters · doi:10.1016/j.cclet.2010.01.034 · Cited by 11
Anti-toxoplasma, antioxidant and cytotoxic activities of Pleopeltis crassinervata (Fée) T. Moore hexane fraction
Anacleto-Santos, J., López-Camacho, P. Y., Mondragón‐Flores, R., Vega‐Avila, E., Basurto‐Islas, G., Mondragón-Castelán, M. E., Carrasco‐Ramírez, E., & Rivera-Fernández, N. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.12.032 · Cited by 10
Artemisinin and artemisinin-related agents
Rawe, S. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-101210-9.00004-4 · Cited by 12

Authors: Liu, C., Zhao, Y., & Wang, Y.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Liu, Chunzhao
Wang, Yuchun
ORCID: Liu, Chunzhao
Zhao, Yan
Wang, Yuchun
Venue: Applied Microbiology and Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2006-06-03
Volume: 72
Issue: 1
Pages: 11-20
ISSN: 0175-7598 (ISSN-L)
1432-0614
DOI: 10.1007/s00253-006-0452-0
OpenAlex: W2051710000
Cited by: 158
References: 102
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 16 · 2012: 8
FWCI: 0.66
Type: journal article
Language: en
Open access: green
ir.ipe.ac.cn
Licence: cc-by-nc-sa
www.springer.com/tdm (tdm)
Locations: Applied Microbiology and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Institute of Process Engineering, CAS Institutional Repository (submittedVersion, cc-by-nc-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Keywords: artemisinin, Artemisia annua, antimalarial drugs, Plasmodium falciparum, chloroquine resistance, cerebral malaria, artemisinin biosynthesis, metabolic engineering, genetic engineering, in vitro tissue culture, bioreactors, plant secondary metabolites
MeSH terms: Antimalarials, Biotechnology, Fermentation, Sesquiterpenes, Technology, Pharmaceutical, Cell Culture Techniques, Bioreactors, Artemisia annua, Artemisinins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks