Cited by 158Plant tissue culture and regenerationPlant biochemistry and biosynthesisSesquiterpenes and Asteraceae Studies

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Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

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Liu, Chunzhao, Zhao, Yan, Wang, Yuchun·2006·Applied Microbiology and Biotechnology

DOI 10.1007/s00253-006-0452-0

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Abstract

Artemisinin isolated from the aerial parts of Artemisia annua L. is a promising and potent antimalarial drug which has a remarkable activity against chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, and is useful in treatment of cerebral malaria. Because the low content (0.01-1 %) of artemisinin in A. annua is a limitation to the commercial production of the drug, many research groups have been focusing their researches on enhancing the production of artemisinin in tissue culture or in the whole plant of A. annua. This review mainly focuses on the progresses made in the production of artemisinin from A. annua by biotechnological strategies including in vitro tissue culture, metabolic regulation of artemisinin biosynthesis, genetic engineering, and bioreactor technology.

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Authors: Liu, C., Zhao, Y., & Wang, Y.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Liu, Chunzhao
Wang, Yuchun
ORCID: Liu, Chunzhao
Zhao, Yan
Wang, Yuchun
Venue: Applied Microbiology and Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2006-06-03
Volume: 72
Issue: 1
Pages: 11-20
ISSN: 0175-7598 (ISSN-L)
1432-0614
DOI: 10.1007/s00253-006-0452-0
OpenAlex: W2051710000
Cited by: 158
References: 102
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 16 · 2012: 8
FWCI: 0.66
Type: journal article
Language: en
Open access: green
ir.ipe.ac.cn
Licence: cc-by-nc-sa
www.springer.com/tdm (tdm)
Locations: Applied Microbiology and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Institute of Process Engineering, CAS Institutional Repository (submittedVersion, cc-by-nc-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Keywords: artemisinin, Artemisia annua, antimalarial drugs, Plasmodium falciparum, chloroquine resistance, cerebral malaria, artemisinin biosynthesis, metabolic engineering, genetic engineering, in vitro tissue culture, bioreactors, plant secondary metabolites
MeSH terms: Antimalarials, Biotechnology, Fermentation, Sesquiterpenes, Technology, Pharmaceutical, Cell Culture Techniques, Bioreactors, Artemisia annua, Artemisinins

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Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

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