Cited by 86biodegradable polymer synthesis and propertiesEnzyme Catalysis and ImmobilizationBiopolymer Synthesis and Applications

Enzymatic and whole-cell synthesis of lactate-containing polyesters: Toward the complete biological production of polylactate

Matsumoto, Ken’ichiro, Taguchi, Seiichi·2010·Applied Microbiology and Biotechnology

Abstract

The importance of polylactic acid, a representative bio-based polyester, has been established on a worldwide scale in response to emerging global environmental problems such as green house gas emission and limited petroleum consumption. The current methods for generating this bio-based polymer involve biological synthesis and lactic acid (LA) fermentation, followed by chemical ring-opening polymerization. Among the research community working on polyhydroxyalkanoate polyesters, the prospect of direct biological synthesis of LA into a polymeric form is very attractive from the academic and industrial perspectives. In 2008, this challenge was met for the first time by the discovery of an "LA-polymerizing enzyme". Using this novel enzyme, the metabolic engineering approach outlined here provided an entirely new, single organism generation of the polymer. This is a major breakthrough in the field. In this review, we provide an overview of the whole-cell synthesis of LA-containing polyesters in comparison with conventional lipase-catalyzed polymer synthesis in terms of both the concepts and strategies of their synthetic processes.

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Crossref · 10.1007/s00253-009-2374-0

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58 of 58 references verified0 citation errors · 0 not checkable

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  • Enzymatic polymerization is more environmentally friendly than chemical synthesis methods.

    “Additionally, according to research, enzymatic polymerization is more environmentally friendly than chemical synthesis methods are.”

    From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [47]

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Authors
Matsumoto, K., & Taguchi, S.
Affiliations
Hokkaido University (JP)
Corresponding author
Taguchi, Seiichi
Venue
Applied Microbiology and Biotechnology
Published
2009-12-10
Volume
85
Issue
4
Pages
921-932
ISSN
  • 0175-7598 (ISSN-L)
  • 1432-0614
OpenAlex
W2056284336
Cited by
86
References
58
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 10 · 2012: 11
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Microbiology and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biopolymer Synthesis and Applications
Keywords
polylactic acid, enzymatic polymerization, polyhydroxyalkanoates, metabolic engineering, lipase-catalyzed polymerization, bio-based polyesters, lactic acid fermentation
MeSH terms
Catalysis, Dioxanes, Fermentation, Hot Temperature, Lipase, Polyesters, Polymers, Lactic Acid

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