Enzymatic and whole-cell synthesis of lactate-containing polyesters: Toward the complete biological production of polylactate
Abstract
The importance of polylactic acid, a representative bio-based polyester, has been established on a worldwide scale in response to emerging global environmental problems such as green house gas emission and limited petroleum consumption. The current methods for generating this bio-based polymer involve biological synthesis and lactic acid (LA) fermentation, followed by chemical ring-opening polymerization. Among the research community working on polyhydroxyalkanoate polyesters, the prospect of direct biological synthesis of LA into a polymeric form is very attractive from the academic and industrial perspectives. In 2008, this challenge was met for the first time by the discovery of an "LA-polymerizing enzyme". Using this novel enzyme, the metabolic engineering approach outlined here provided an entirely new, single organism generation of the polymer. This is a major breakthrough in the field. In this review, we provide an overview of the whole-cell synthesis of LA-containing polyesters in comparison with conventional lipase-catalyzed polymer synthesis in terms of both the concepts and strategies of their synthetic processes.
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Enzymatic polymerization is more environmentally friendly than chemical synthesis methods.
“Additionally, according to research, enzymatic polymerization is more environmentally friendly than chemical synthesis methods are.”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [47]
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Synthesis and Biological Application of Polylactic Acid
Li, G., Zhao, M., Xu, F., Yang, B., Li, X., Meng, X., Teng, L., Sun, F., & Li, Y. (2020) · Molecules · doi:10.3390/molecules25215023 · Cited by 492 · see citing works
“However, not many references are available for this method [47].”
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- Authors
- Matsumoto, K., & Taguchi, S.
- Affiliations
- Hokkaido University (JP)
- Corresponding author
- Taguchi, Seiichi
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2009-12-10
- Volume
- 85
- Issue
- 4
- Pages
- 921-932
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W2056284336
- Cited by
- 86
- References
- 58
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 10 · 2012: 11
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Applied Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biopolymer Synthesis and Applications
- Keywords
- polylactic acid, enzymatic polymerization, polyhydroxyalkanoates, metabolic engineering, lipase-catalyzed polymerization, bio-based polyesters, lactic acid fermentation
- MeSH terms
- Catalysis, Dioxanes, Fermentation, Hot Temperature, Lipase, Polyesters, Polymers, Lactic Acid
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