Incidentally detected pancreatic adenocarcinomas on computed tomography obtained during the follow-up for other diseases
Abstract
Purpose To determine imaging findings of pancreatic adenocarcinomas incidentally detected on contrast-enhanced multiphasic dynamic computed tomography (CT) obtained during the follow-up for other diseases. Methods From January 2007 to December 2018, 14 patients with pancreatic adenocarcinomas incidentally detected on CT obtained during the follow-up for other diseases (incidental group) and 105 patients with pancreatic adenocarcinomas symptomatically detected on ultrasound or CT (non-incidental group) were included. Imaging characteristics of the tumor were compared between the two groups. Additionally, imaging findings prior to the detection of a tumor on previous CT images in the incidental group were also assessed. Results In cancers of the pancreas body/tail, there was a significantly smaller tumor size (median, 17 mm vs. 42 mm, p < 0.001), a significantly lower incidence of loss of fatty marbling (p = 0.025), vascular involvement (p < 0.001), lymph node metastasis (p = 0.046) and distant metastasis (p = 0.017), and a significantly higher incidence of preserved lobulation (p < 0.001) in the incidental group than in the non-incidental group. Regarding the cancers of the pancreas head, there were no significant differences in the radiological findings between the two groups. On previous CT images, small pancreatic nodules, secondary signs, and loss of fatty marbling tended to be the preceding findings of incidental pancreatic adenocarcinomas. Conclusion Incidentally detected pancreatic adenocarcinomas in the pancreas body/tail were characterized by an earlier tumor stage than in cases of symptomatically detected pancreatic adenocarcinoma. Several CT findings prior to the detection of a tumor may be useful for the early detection of pancreatic adenocarcinoma during the follow-up for other diseases.
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Suspected lesions of pancreatic cancer have been found in 40-85% of cases where CT was conducted before a pancreatic cancer diagnosis.
“Suspected lesions of pancreatic cancer have been found in 40–85% of cases where CT was conducted before a pancreatic cancer diagnosis (11,16-18).”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [17]
Higashi et al. reported that, among 14 patients, small nodules were found in 40% of patients and pancreatic duct dilatation in 36% of patients on prediagnostic CT within 18 months before a pancreatic cancer diagnosis.
“Higashi et al. (17) also reported that, among 14 patients, small nodules were found in 40% of patients and pancreatic duct dilatation in 36% of patients on prediagnostic CT within 18 months before a pancreatic cancer diagnosis.”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [17]
Cites
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Factors associated with missed and misinterpreted cases of pancreatic ductal adenocarcinoma
Kang, J. D., Clarke, S. E., & Costa, A. F. (2021) · European Radiology · doi:10.1007/s00330-020-07307-5 · Cited by 84 · see citing works
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“The average size was 16.4 mm. Higashi et al. (17) also reported that, among 14 patients, small nodules were found in 40% of patients and pancreatic duct dilatation in 36% of patients on prediagnostic CT within 18 months before a pancreatic cancer diagnosis.”
Influential
- Authors
- Higashi, M., Tanabe, M., Onoda, H., Nakao, S., Miyoshi, K., Iida, E., Okada, M., Furukawa, M., & Ito, K.
- Affiliations
- Yamaguchi University (JP)
- Corresponding author
- Higashi, Mayumi
- Venue
- Abdominal Radiology
- Published
- 2019-12-12
- Volume
- 45
- Issue
- 3
- Pages
- 774-781
- ISSN
- 2366-004X (ISSN-L)
- 2366-0058
- OpenAlex
- W2994697180
- Cited by
- 10
- References
- 4
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2021: 3 · 2020: 2
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Abdominal Radiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (17H02110, 19K09824)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Keywords
- pancreatic ductal adenocarcinoma, incidental finding, early detection, contrast-enhanced CT, tumor stage, pancreatic head, lymph node metastasis, distant metastasis, vascular involvement, follow-up imaging
- MeSH terms
- Adenocarcinoma, Aged, Aged, 80 and over, Contrast Media, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Pancreatic Neoplasms, Retrospective Studies, Tomography, X-Ray Computed, Incidental Findings
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