Indicative findings of pancreatic cancer in prediagnostic CT
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We examined 20 prediagnostic CTs from 16 patients for whom the diagnosis of pancreatic cancer was delayed until full diagnostic CT was performed. Three radiologists independently reviewed the prediagnostic CTs along with 50 CTs of control subjects, including patients without pancreatic disease (n = 38) or with chronic pancreatitis without calcification visible on CT (n = 12). The reviewers recorded the presence of biliary or pancreatic ductal dilation, interruption of the pancreatic duct, distal parenchymal atrophy, contour abnormality and focal hypoattenuation. Frequency, sensitivity and specificity of the significant findings were calculated. Logistic regression analysis was performed. Findings indicative of pancreatic cancer were seen on 85% (17/20) of the prediagnostic CTs. Patients with pancreatic cancer were significantly (p < 0.05) more likely to show focal hypoattenuation, pancreatic duct dilation, interruption of the pancreatic duct, and distal parenchymal atrophy, with sensitivities and specificities of 75%/84%, 50%/78%, 45%/82% and 45%/96%, respectively. Focal hypoattenuation and distal parenchymal atrophy were the independent predictors of pancreatic cancer with odds ratios of 20.92 and 11.22, respectively. In conclusion, focal hypoattenuation and pancreatic duct dilation with or without interruption, especially when accompanied by distal parenchymal atrophy, were the most useful findings for avoiding delayed diagnosis of pancreatic cancer.
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MPD abnormalities are not specific to PDAC and are often observed in benign pancreatic diseases.
“However, MPD abnormalities are not specific to PDAC and are often observed in benign pancreatic diseases.”
Suspected lesions of pancreatic cancer have been found in 40-85% of cases where CT was conducted before a pancreatic cancer diagnosis.
“Suspected lesions of pancreatic cancer have been found in 40–85% of cases where CT was conducted before a pancreatic cancer diagnosis (11,16-18).”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [11]
Main pancreatic duct dilatation and distal parenchymal atrophy are characteristic findings of early pancreatic cancer.
“In addition, main pancreatic duct dilatation and distal parenchymal atrophy are characteristic findings of early pancreatic cancer (9-12).”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [11]
Distal parenchymal atrophy is another characteristic feature of early pancreatic cancer and may be associated with a hypoattenuating mass or focal pancreatic duct dilatation.
“Distal parenchymal atrophy is another characteristic feature of early pancreatic cancer and may be associated with a hypoattenuating mass or focal pancreatic duct dilatation (11,32,34).”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [11]
Pancreatic duct dilatation and interruption are the most important secondary findings of pancreatic cancer.
“Pancreatic duct dilatation and interruption are the most important secondary findings of pancreatic cancer, and they can be a crucial key in diagnosing small pancreatic cancer (11,12,16,28).”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [11]
Distal parenchymal atrophy was present in 4% of controls without pancreatic diseases.
“Distal parenchymal atrophy was present in 4% of controls without pancreatic diseases (11,35) and in 7.1–15.8% of patients with benign main pancreatic duct stricture (32,34,36).”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [11]
Ahn et al. reported that findings indicative of pancreatic cancer were observed on 85% (17/20) of prediagnostic CTs, and that focal hypoattenuation, pancreatic duct dilatation, and distal parenchymal atrophy were significant findings to observe to avoid missing a diagnosis of pancreatic cancer.
“Ahn et al. (11) reported that findings indicative of pancreatic cancer were observed on 85% (17/20) of the prediagnostic CTs, and that focal hypoattenuation, pancreatic duct dilatation, and distal parenchymal atrophy were significant findings to observe to avoid missing a diagnosis of pancreatic cancer.”
From Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer (2023) · cites this paper as [11]
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- Authors
- Ahn, S. S., Kim, M.-J., Choi, J.-Y., Hong, H.-S., Chung, Y. E., & Lim, J. S.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Kim, Myeong-Jin
- Venue
- European Radiology
- Published
- 2009-05-05
- Volume
- 19
- Issue
- 10
- Pages
- 2448-2455
- ISSN
- 0938-7994 (ISSN-L)
- 1432-1084
- OpenAlex
- W2108632649
- Cited by
- 105
- References
- 31
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- link.springer.com
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- European Radiology (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Keywords
- pancreatic cancer, delayed diagnosis, pancreatic duct dilatation, chronic pancreatitis, diagnostic accuracy, early detection
- MeSH terms
- Adult, Diagnosis, Differential, Female, Humans, Male, Pancreas, Pancreatic Neoplasms, Pancreatitis, Sensitivity and Specificity, Tomography, X-Ray Computed, Reproducibility of Results, Early Diagnosis, Delayed Diagnosis
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