Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late

Guirao, Xavier; Lowry, Stephen F.

doi:10.1007/s002689900069

Cited by 102Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late

Guirao, Xavier, Lowry, Stephen F.·1996·World Journal of Surgery

DOI 10.1007/s002689900069

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Abstract

A generalized host inflammatory response is necessary to orchestrate the maintenance or recovery of tissue repair and immune competence following severe injury or infection. When excessive in initial magnitude or duration, however, these otherwise beneficial inflammatory processes may eventuate in deterioration rather than restoration of homeostasis. Although the adverse consequences of excessive inflammatory stimuli may be acutely evident, their influences are more often insidious. A complex cascade of endogenously derived proinflammatory mediators are currently hypothesized to be responsible for both the beneficial and the adverse sequelae of infection and injury. The cytokine proteins tumor necrosis factor and interleukin 1 have been most widely studied as potential targets for antagonist intervention in both experimental models and prospective clinical trials. Preclinical evidence supporting these approaches is briefly discussed herein, as are the results of clinical trials attempting to modulate cytokine influences in the presence of sepsis. The present discussion focuses on potential insights gained from these investigations and the evolving appreciation for the importance of cytokine counterregulatory mechanisms. Examples of potentially complex interactions between inflammatory cytokines and infection‐induced antagonist proteins or counterregulatory hormones are provided. It is hypothesized that a sustained imbalance among these proinflammatory and counterregulatory influences may be a critical determinant of outcome in patients with severe infection.

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Successful repair of injured tissues requires diverse interactions among different cells, biochemical mediators, and the cellular microenvironment.
“Successful repair of injured tissues requires diverse interactions among different cells, biochemical mediators, and the cellular microenvironment47–49.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [49]

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Inflammatory cytokines and cell response in surgery
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Lidocaína por via venosa intraoperatória
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Neurokinin-1 Receptor and Substance P Messenger RNA Levels Increase during Intraabdominal Adhesion Formation
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Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis
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Association of Obesity With Inflammation and Pain After Total Hip Arthroplasty
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Biochemical Markers Associated With Acute Vocal Fold Wound Healing: A Rabbit Model
Branski, R. C., Rosen, C. A., Verdolini, K., & Hebda, P. A. (2005) · Journal of Voice · doi:10.1016/j.jvoice.2004.04.003 · Cited by 55 · see citing works
Intraoperative Intravenous Lidocaine
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Host Defense Response and Outcome in ARDS
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Anthocyanins From Black Soybean Seed Coat Enhance Wound Healing
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PERIPHERAL HEMOPHAGOCYTOSIS
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Levels of vasodilators (SP, CGRP) and vasoconstrictor (NPY) peptides in early human burns
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Peptidomimetic Fluoromethylketone Rescues Mice from Lethal Endotoxic Shock
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Growth Hormone Down-Regulation of Interleukin-1?? and Interleukin-6 Induced Acute Phase Protein Gene Expression is Associated with Increased Gene Expression of Suppressor of Cytokine Signal-3
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Psychoneuroimmunology in Critically Ill Patients
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The Inhibitory Effects of Interleukin‐1 on Growth Hormone Action During Catabolic Illness
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Gene expression analysis of follicular cells revealed inflammation as a potential IVF failure cause
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Severe Postoperative Complications may be Related to Mesenteric Traction Syndrome during Open Esophagectomy
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Besaran Neutrofil dan Kadar C-reactive Protein sebagai Faktor Prognostik Multi Organ Failure pada Pasien Multi-trauma
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Vocal Fold Fibroblast Response to Mechanical Stress
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Early Detection of Sepsis, MOF and Outcome Prediction in Severely Traumatized Patients
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Characterization of the In Vitro Anti-inflammatory Activity of AL-5898 and Related Benzopyranyl Esters and Amides
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Immunomodulation of Cell-Mediated Responses: Is It Feasible?
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Authors: Guirao, X., & Lowry, S. F.
Affiliations: NewYork–Presbyterian Hospital (US)
ORCID: Guirao, Xavier
Venue: World Journal of Surgery
Publisher: Wiley
Published: 1996-05
Volume: 20
Issue: 4
Pages: 437-446
ISSN: 0364-2313 (ISSN-L)
1432-2323
DOI: 10.1007/s002689900069
OpenAlex: W2035192249
Cited by: 102
References: 80
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 2
FWCI: 5.78
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: World Journal of Surgery (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service
National Institute of General Medical Sciences (GM-34695)
Topics: Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: host inflammatory response, injuries, infection, sepsis, cytokines, TNF-α, interleukin-1, cytokine antagonists, counterregulatory hormones, pro-inflammatory mediators, tissue repair, immunocompetence, cytokine imbalance
MeSH terms: Animals, Clinical Trials as Topic, Critical Care, Homeostasis, Humans, Immunocompetence, Multiple Organ Failure, Multiple Trauma, Wound Healing, Survival Rate, Cytokines, Treatment Outcome, Inflammation Mediators

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Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late

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