Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Abstract
Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist.
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IL-1Ra binds with IL-1R.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
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Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works
Endometrial receptivity markers, the journey to successful embryo implantation.
Achache, H., & Revel, A. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml004 · Cited by 952 · see citing works
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772 · see citing works
Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.949bp.x · Cited by 673 · see citing works
Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M., & Iwakura, Y. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1463 · Cited by 611 · see citing works
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
Tahtinen, S., Tong, A.-J., Himmels, P., Oh, J., Paler-Martinez, A., Kim, L., Wichner, S., Oei, Y., McCarron, M. J., Freund, E. C., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01160-y · Cited by 535 · see citing works
Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000586 · Cited by 380 · see citing works
Tilders, F. J. H., DeRuk, R. H., Van Dam, A.-M., Vincent, V. A. M., Schotanus, K., & Persoons, J. H. A. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90010-8 · Cited by 277 · see citing works
Wood, J. A., Wood, P. L., Ryan, R., Graff-Radford, N. R., Pilapil, C., Robitaille, Y., & Quirion, R. (1993) · Brain Research · doi:10.1016/0006-8993(93)91327-o · Cited by 244 · see citing works
Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage.
Abramson, S. B. (2002) · Rheumatology · doi:10.1093/rheumatology/41.9.972 · Cited by 217 · see citing works
Ishida, Y., Kondo, T., Kimura, A., Matsushima, K., & Mukaida, N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5598 · Cited by 168 · see citing works
Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice
Somm, E., Henrichot, E., Pernin, A., Juge-Aubry, C. E., Muzzin, P., Dayer, J.-M., Nicklin, M. J. H., & Meier, C. A. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3503 · Cited by 114 · see citing works
Cultured sympathetic neurons synthesize and release the cytokine interleukin 1 beta.
Freidin, M., Bennett, M. V., & Kessler, J. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10440 · Cited by 113 · see citing works
Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late
Guirao, X., & Lowry, S. F. (1996) · World Journal of Surgery · doi:10.1007/s002689900069 · Cited by 102 · see citing works
Schmid, A. W., Lynch, M. A., & Herron, C. E. (2009) · Hippocampus · doi:10.1002/hipo.20542 · Cited by 64 · see citing works
Charbonneau, B., Maurer, M. J., Ansell, S. M., Slager, S. L., Fredericksen, Z. S., Ziesmer, S. C., Macon, W. R., Habermann, T. M., Witzig, T. E., Link, B. K., et al. (2012) · Cytokine · doi:10.1016/j.cyto.2012.08.028 · Cited by 55 · see citing works
Balakumar, A., Das, D., Datta, A., Mishra, A., Bryak, G., Ganesh, S. M., Netea, M. G., Kumar, V., Lionakis, M. S., Arora, D., et al. (2024) · PLOS Pathogens · doi:10.1371/journal.ppat.1012699 · Cited by 25 · see citing works
- Authors
- Hannum, C. H., Wilcox, C. J., Arend, W. P., Joslin, F. G., Dripps, D. J., Heimdal, P. L., Armes, L. G., Sommer, A., Eisenberg, S. P., & Thompson, R. C.
- Venue
- Nature
- Published
- 1990-01
- Volume
- 343
- Issue
- 6256
- Pages
- 336-340
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2007210793
- Cited by
- 1,122
- References
- 1
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 19 · 2023: 8 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 11 · 2018: 15 · 2017: 10 · 2016: 16 · 2015: 18 · 2014: 8 · 2013: 9 · 2012: 21
- FWCI
- 58.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- interleukin-1 receptor antagonist, IL-1 inhibitors, interleukin-1 receptor, receptor antagonism, glycosylation, monocyte-conditioned medium, protein purification
- MeSH terms
- Amidohydrolases, Amino Acid Sequence, Binding, Competitive, Cells, Cultured, Chromatography, Chromatography, High Pressure Liquid, Electrophoresis, Polyacrylamide Gel, Fibroblasts, Glycosylation, Humans, Interleukin-1, Molecular Sequence Data, Monocytes, Peptide Fragments, Proteins, Receptors, Immunologic, Recombinant Proteins, Sialoglycoproteins, Dinoprostone, Receptors, Interleukin-1, Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase, Interleukin 1 Receptor Antagonist Protein
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