The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma
Open accessAbstract
Purpose Insulin-like growth factor 1 receptor signaling through upregulation of the stimulatory ligand IGF-II has been implicated in the pathogenesis of adrenocortical carcinoma. As there is a paucity of effective therapies, this dose expansion cohort of a phase 1 study was undertaken to determine the safety, tolerability, pharmacokinetics, and effects on endocrine markers of figitumumab in patients with adrenocortical carcinoma.Methods Figitumumab was administered on day 1 of each 21-day cycle at the maximal feasible dose (20 mg/kg) to a cohort of patients with metastatic, refractory adrenocortical carcinoma. Serum glucose, insulin, and growth hormone were measured pre-study, at cycle 4 and study end. Pharmacokinetic evaluation was performed during cycles 1 and 4.Results Fourteen patients with adrenocortical carcinoma received 50 cycles of figitumumab at the 20 mg/kg. Treatment-related toxicities were generally mild and included hyperglycemia, nausea, fatigue, and anorexia. Single episodes of grade 4 hyperuricemia, proteinuria, and elevated gamma-glutamyltransferase were observed. Pharmacokinetics of figitumumab was comparable to patients with solid tumors other than adrenocortical carcinoma. Treatment with figitumumab increased serum insulin and growth hormone levels. Eight of 14 patients (57%) had stable disease.Conclusions The side effect profile and pharmacokinetics of figitumumab were similar in patients with adrenocortical carcinoma in comparison to patients with other solid tumors. While hyperglycemia was the most common adverse event, no clear patterns predicting severity were observed. The majority of patients receiving protocol therapy with single agent figitumumab experienced stability of disease, warranting further evaluation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Eight of 14 patients had stable disease as their best response. However, after 7 cycles (∼6 months), all patients showed disease progression.”
From Adrenocortical carcinoma (2014) · cites this paper as [316]
In the citing paper
“Eight of 14 patients had stable disease as their best response.”
From Adrenocortical carcinoma (2014) · cites this paper as [316]
In the citing paper
“The first study investigated figtilimumab, a fully human monoclonal antibody directed toward IGF-1R (316). Treatment-related toxicities were generally mild and mainly included hyperglycemia, nausea, fatigue, and anorexia.”
From Adrenocortical carcinoma (2014) · cites this paper as [316]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Karp, D. D., Paz-Ares, L. G., Novello, S., Haluska, P., Garland, L. L., Cardenal, F., Blakely, L. J., Eisenberg, P. D., Langer, C. J., Blumenschein, G. R., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.9331 · Cited by 260
Self-citationRetractedGibaldi, M., & Perrier, D. G. (1982) · CRC Press eBooks · doi:10.1201/b14095 · Cited by 4,093
Circulating concentrations of insulin-like growth factor I and risk of breast cancer
Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B. J., ROSNER, B. A., Speizer, F. E., & Pollak, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10384-1 · Cited by 1,822
Insulin-like growth factors and neoplasia
Pollak, M., Schernhammer, E. S., & Hankinson, S. E. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1387 · Cited by 1,477
Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173
The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights
Samani, A. A., Yakar, S., LeRoith, D., & Brodt, P. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0001 · Cited by 1,017
Le Roith, D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702273360907 · Cited by 897
Adjuvant Mitotane Treatment for Adrenocortical Carcinoma
Terzolo, M., Angeli, A., Faßnacht, M., Daffara, F., Tauchmanovà, L., Conton, P. A., Rossetto, R., Buci, L., Sperone, P., Grossrubatscher, E. M., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063360 · Cited by 759
Icard, P., Goudet, P., Charpenay, C., Andreassian, B., Carnaille, B., Chapuis, Y., Cougard, P., Henry, J., & Proye, C. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0047-y · Cited by 543
Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
Giordano, T. J., Thomas, D. G., Kuick, R., Lizyness, M., Misek, D. E., Smith, A. L., Sanders, D., Aljundi, R. T., Gauger, P. G., Thompson, N. W., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63846-1 · Cited by 383
Cohen, B. D., Baker, D. A., Soderstrom, C. I., Tkalcevic, G. T., Rossi, A. M., Miller, P. E., Tengowski, M. W., Wang, F., Gualberto, A., BEEBE, J. S., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1070 · Cited by 367
Self-citationHaluska, P., Shaw, H. M., Batzel, G. N., Yin, D., Molina, J. R., Molife, L. R., Yap, T. A., Roberts, M. L., Sharma, A., Gualberto, A., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1118 · Cited by 269
Self-citationGee, J. M. W., Robertson, J. F. R., Gutteridge, E., Ellis, I. O., Pinder, S. E., Rubini, M., & Nicholson, R. I. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.01005 · Cited by 209
Knowlden, J. M., Hutcheson, I. R., Barrow, D., Gee, J. M. W., & Nicholson, R. I. (2005) · Endocrinology · doi:10.1210/en.2005-0247 · Cited by 191
Sachdev, D., Li, S. L., Hartell, J. S., Fujita‐Yamaguchi, Y., Miller, J. S., & Yee, D. (2003) · PubMed · Cited by 190
Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma
Barlaskar, F. M., Spalding, A. C., Heaton, J. H., Kuick, R., Kim, A. C., Thomas, D. G., Giordano, T. J., Ben-Josef, E., & Hammer, G. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1456 · Cited by 189
Self-citationIGF-I mediated survival pathways in normal and malignant cells
Kurmasheva, R. T., & Houghton, P. J. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.05.003 · Cited by 186
Gene Expression Profiling of Childhood Adrenocortical Tumors
West, A. N., Neale, G. A. M., Pounds, S. B., de Figueiredo, B. C., Galindo, C. R., Pianovski, M. A. D., Filho, A. G. O., Malkin, D. M., Lalli, E., Ribeiro, R. C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3767 · Cited by 165
Lacy, M. Q., Alsina, M., Fonseca, R., Paccagnella, M. L., Melvin, C. L., Yin, D., Sharma, A., Enriquez-Sarano, M. L., Pollak, M., Jagannath, S., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.9319 · Cited by 164
Self-citationRoith, D. L., & Werner, H. (2002) · Elsevier eBooks · doi:10.1016/b0-12-227555-1/00108-8 · Cited by 157
Kalli, K. R., Falowo, O. I., Bale, L. K., Zschunke, M. A., Roche, P. C., & Conover, C. A. (2002) · Endocrinology · doi:10.1210/en.2001-211408 · Cited by 154
Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.
Cola, G. D., Cool, M. H., & Accili, D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119438 · Cited by 153
Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy
Velázquez‐Fernández, D., Laurell, C., Geli, J., Höög, A., Odeberg, J., Kjellman, M., Lundeberg, J., Hamberger, B., Nilsson, P., & Bäckdahl, M. (2005) · Surgery · doi:10.1016/j.surg.2005.09.031 · Cited by 135
Impact of IGF‐1R/EGFR cross‐talks on hepatoma cell sensitivity to gefitinib
Desbois‐Mouthon, C., Cacheux, W., Eggelpoël, M.-J. B.-V., Barbu, V. D., Fartoux, L., Poupon, R. Y., Housset, C., & Rosmorduc, O. (2006) · International Journal of Cancer · doi:10.1002/ijc.22221 · Cited by 111
The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge
Durai, R., Yang, W., Gupta, S., Seifalian, A. M., & Winslet, M. C. (2005) · International Journal of Colorectal Disease · doi:10.1007/s00384-004-0675-4 · Cited by 110
Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase.
Grønborg, M., Wulff, B. S., Rasmussen, J. S., Kjeldsen, T., & Gammeltoft, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49481-7 · Cited by 109
Emerging Treatment Strategies for Adrenocortical Carcinoma: A New Hope
Kirschner, L. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1739 · Cited by 107
Chang, Y. S., Kong, G., Sun, S., Liu, D., El‐Naggar, A. K., Khuri, F. R., Hong, W. K., Lee, H., & Gong, K. (2002) · PubMed · Cited by 99
EFFECT OF ACUTE ADMINISTRATION OF INSULIN-LIKE GROWTH FACTOR I IN PATIENTS WITH LARON-TYPE DWARFISM
Laron, Z., Erster, B., Klinger, B., & Anin, S. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90236-x · Cited by 98
Camirand, A., Lu, Y., & Pollak, M. (2002) · PubMed · Cited by 98
Insulin-like growth factor receptors in normal and tumorous adult human adrenocortical glands
Weber, M. M., Auernhammer, C. J., Kieß, W., & Engelhardt, D. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1360296 · Cited by 95
Insulin-like Growth Factor-I Receptor Signaling Blockade Combined with Radiation
Allen, G. W., Saba, C., Armstrong, E. A., Huang, S., Benavente, S., Ludwig, D. L., Hicklin, D. J., & Harari, P. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2000 · Cited by 94
Cardillo, M. R., Monti, S., Silverio, F. D., Gentile, V., Sciarra, F., & Toscano, V. (2003) · PubMed · Cited by 89
Wiseman, L. R., Johnson, M. D., Wakeling, A. E., Lykkesfeldt, A. E., May, F. E. B., & Westley, B. R. (1993) · European Journal of Cancer · doi:10.1016/0959-8049(93)90218-5 · Cited by 87
ドーパミン‐β‐ヒドロキシラーゼ欠乏症における前駆体療法による内因性ノルアドレナリンの回復
Biaggioni, I., & Robertson, D. (1987) · The Lancet · Cited by 68
Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice.
Chang, P.-Y., Benecke, H., MARCHAND‐BRUSTEL, Y. L., Lawitts, J. A., & Moller, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33969-8 · Cited by 56
Wan, X., & Helman, L. (2002) · Neoplasia · doi:10.1038/sj.neo.7900242 · Cited by 51
Increased Expression of Insulin-Like Growth Factor I is Associated with Ara-C Resistance in Leukemia
Abe, S., Funato, T., Takahashi, S., Yokoyama, H., Yamamoto, J., Tomiya, Y., Yamada‐Fujiwara, M., Ishizawa, K., Kameoka, J., Kaku, M., et al. (2006) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.209.217 · Cited by 46
Yin, D., Tamaki, N., Parent, A. D., & Zhang, J. H. (2005) · Neurological Research · doi:10.1179/016164105x18151 · Cited by 26
Self-citationCharacterization of NSCLC patients responding to anti-IGF-IR therapy
Gualberto, A., Melvin, C. L., Dean, A., Ang, A. L., Reynolds, J. M., Lee, A., Terstappen, L. W. M. M., Haluska, P., Lipton, A., & Karp, D. D. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.8000 · Cited by 24
Self-citationWajchenberg (2000) · doi:10.1002/(sici)1097-0142(20000215)88:4
Cited by
Sorted by citations
Faßnacht, M., Dekkers, O. M., Else, T., Baudin, É., Berruti, A., de Krijger, R. R., Haak, H. R., Mihai, R., Assié, G., & Terzolo, M. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0608 · Cited by 976
Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892
Self-citationFaßnacht, M., Berruti, A., Baudin, É., Demeure, M. J., Gilbert, J., Haak, H. R., Kroiß, M., Quinn, D. I., Hesseltine, E., Ronchi, C. L., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)70081-1 · Cited by 342
Self-citationOlmos, D., Postel-Vinay, S. C., Molife, L. R., Okuno, S. H., Schuetze, S. M., Paccagnella, M. L., Batzel, G. N., Yin, D., Pritchard‐Jones, K., Judson, I. R., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70354-7 · Cited by 339
Self-citationCancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?
Klil-Drori, A. J., Azoulay, L., & Pollak, M. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.120 · Cited by 212
Metadata
- Authors
- Haluska, P., Worden, F., Olmos, D., Yin, D., Schteingart, D., Batzel, G. N., Paccagnella, M. L., de Bono, J. S., Gualberto, A., & Hammer, G. D.
- Affiliations
- Mayo Clinic (US)
- University of Michigan (US)
- Royal Marsden NHS Foundation Trust (GB)
- Pfizer (United States) (US)
- Corresponding author
- Haluska, Paul
- Hammer, Gary D.
- Venue
- Cancer Chemotherapy and Pharmacology
- Published
- 2009-08-02
- Volume
- 65
- Issue
- 4
- Pages
- 765-773
- ISSN
- 0344-5704 (ISSN-L)
- 1432-0843
- PMC
- PMC2875253
- OpenAlex
- W2065302180
- Cited by
- 197
- References
- 41
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 13 · 2017: 8 · 2016: 17 · 2015: 17 · 2014: 18 · 2013: 20 · 2012: 20
- FWCI
- 17.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cancer Chemotherapy and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K12CA090628)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- figitumumab, adrenocortical carcinoma, pharmacokinetics, safety and tolerability, hyperglycemia, insulin-like growth factor II, growth hormone, serum insulin, disease stability
- MeSH terms
- Adrenal Cortex Neoplasms, Adult, Aged, Anorexia, Antibodies, Monoclonal, Drug Administration Schedule, Fatigue, Female, Humans, Hyperglycemia, Infusions, Intravenous, Insulin, Male, Metabolic Clearance Rate, Middle Aged, Nausea, Growth Hormone, Cohort Studies, Immunoglobulins, Intravenous, Treatment Outcome, Receptor, IGF Type 1, Adrenocortical Carcinoma, Area Under Curve, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
