Insulin-Like Growth Factors

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488 · see citing works

Role of insulin-like growth factors in embryonic and postnatal growth

Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463 · see citing works

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

Daughaday, W. H., & Rotwein, P. S. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-1-68 · Cited by 1,718 · see citing works

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

LeRoith, D., Werner, H., Beitner‐Johnson, D., & Roberts, C. T. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-143 · Cited by 1,424 · see citing works

Insulin Resistance — Mechanisms, Syndromes, and Implications

Epstein, F. H., Moller, D. E., & Flier, J. S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251307 · Cited by 800 · see citing works

Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta.

King, G. L., Goodman, A. D., Buzney, S. M., Moses, A. C., & Kahn, C. R. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111764 · Cited by 437 · see citing works

Dietary components that regulate serum somatomedin-C concentrations in humans.

Isley, W. L., Underwood, L. E., & Clemmons, D. R. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110757 · Cited by 434 · see citing works

The Molecular Mechanism of Insulin Action

Kahn, C. R. (1985) · Annual Review of Medicine · doi:10.1146/annurev.me.36.020185.002241 · Cited by 432 · see citing works

Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated Hypoglycemia

Daughaday, W. H., Emanuele, M. A., Brooks, M. H., Barbato, A. L., Kapadia, M., & Rotwein, P. S. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812013192202 · Cited by 348 · see citing works

Insulin-like Growth Factors and Cancer

LeRoith, D., Baserga, R., Helman, L., & Roberts, C. T., Jr. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-1-199501010-00009 · Cited by 317 · see citing works

Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.

El‐Badry, O. M., Minniti, C. P., Kohn, E. C., Houghton, P. J., Daughaday, W. H., & Helman, L. J. (1990) · PubMed · Cited by 249 · see citing works

Effects of insulin-like growth factor on linear growth, head circumference, and body fat in patients with Laron-type dwarfism

Laron, Z., Anin, S., Aurbach-Klipper, Y., & Klinger, B. (1992) · The Lancet · doi:10.1016/0140-6736(92)91594-x · Cited by 212 · see citing works

Insulin-like Growth Factors in Health and Disease

LeRoith, D., Clemmons, D. R., NISSLEY, P. S., & Rechler, M. M. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-10-854 · Cited by 161 · see citing works

Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.

Zenobi, P. D., Jaeggi-Groisman, S. E., Riesen, W. F., Røder, M. E., & Froesch, E. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116109 · Cited by 143 · see citing works

Clinical Uses of Insulin-like Growth Factor I

Bondy, C. A., Underwood, L. E., Clemmons, D. R., et al. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-7-199404010-00011 · Cited by 136 · see citing works

Recombinant human insulin-like growth factor I (rhIGF I) reduces hyperglycaemia in patients with extreme insulin resistance

Schoenle, E. J., Zenobi, P. D., Torresani, T., et al. (1991) · Diabetologia · doi:10.1007/bf00400998 · Cited by 114 · see citing works

Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

LeRoith, D., Adamo, M. L., Werner, H., & Roberts, C. T. (1991) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(91)90003-6 · Cited by 109 · see citing works

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene

Taylor, S. I. (1992) · Diabetes · doi:10.2337/diabetes.41.11.1473 · Cited by 108 · see citing works

Impaired Formation of the Ternary Insulin-Like Growth Factor-Binding Protein Complex in Patients with Hypoglycemia due to Nonislet Cell Tumors*

Baxter, R. C., & Daughaday, W. H. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-4-696 · Cited by 104 · see citing works

Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes

Moses, A. C., Young, S. C., Morrow, L. A., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.1.91 · Cited by 69 · see citing works

Acute Response to Recombinant Insulin-like Growth Factor I in a Patient with Mendenhall's Syndrome

Quin, J., Fisher, B. M., Paterson, K., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011153232016 · Cited by 67 · see citing works

Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography.

Eastman, R. C., Carson, R. E., Orloff, D. G., Cochran, C., Perdue, J. F., Rechler, M. M., Lanau, F., Roberts, C. T., Shapiro, J., & Roth, J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115803 · Cited by 66 · see citing works

Insulin-Like Growth Factor-1 Therapy in Diabetes: Physiologic Basis, Clinical Benefits, and Risks

Kolaczynski, J. W., & Caro, J. F. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-1-199401010-00009 · Cited by 61 · see citing works

Insulin-Like Growth Factor-II in Nonislet Cell Tumors Associated with Hypoglycemia: Increased Levels of Messenger Ribonucleic Acid*

Lowe, W. L., Roberts, C. T., LeRoith, D., et al. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-6-1153 · Cited by 57 · see citing works

Trial of insulinlike growth factor I therapy for patients with extreme insulin resistance syndromes

Kuzuya, H., Matsuura, N., Sakamoto, M., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.5.696 · Cited by 52 · see citing works

Serum levels of insulin‐like growth factor (IGF) I, II and IGF binding protein in diabetic adolescents treated with continuous subcutaneous insulin infusion

Hall, K., Johansson, B., Pòvoa, G., et al. (1989) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1989.tb00078.x · Cited by 50 · see citing works

Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome--a clinical research center study. GHIS Collaborative Group

Backeljauw, P. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.9.3312 · Cited by 50 · see citing works

IGFs: function and clinical importance 3 Role of insulin‐like growth factor (IGF) II and IGF binding proteins in extrapancreatic tumour hypoglycaemia

Zapf, J. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb01012.x · Cited by 48 · see citing works

Treatment with recombinant human insulin-like growth factor I of children with growth hormone receptor deficiency (Laron syndrome). Kabi Pharmacia Study Group on Insulin-like Growth Factor I Treatment in Growth Hormone Insensitivity Syndromes.

Wilton, P. (1992) · PubMed · Cited by 44 · see citing works

Insulin-like growth factor I (rhIGF-I) as a therapeutic agent for hyperinsulinemic insulin-resistant diabetes mellitus

MOSES, A. C., Morrow, L., O’Brien, M. E., et al. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(95)01084-q · Cited by 40 · see citing works

Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients

Jabri, N., Ds, S., Schwartz, S. L., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.3.369 · Cited by 32 · see citing works

Insulin-like growth factors (IGFs) and IGF-I treatment in the adolescent with insulin-dependent diabetes mellitus

Dunger, D. B., Cheetham, T. D., & Crowne, E. C. (1995) · Metabolism · doi:10.1016/0026-0495(95)90232-5 · Cited by 30 · see citing works

Clinical review 59: Uses of human insulin-like growth factor-I in clinical conditions

Clemmons, D. R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.1.4 · Cited by 25 · see citing works

The effects of subcutaneous insulin-like growth factor-I infusion in insulin-dependent diabetes mellitus

Bach, M. A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.4.1040 · Cited by 21 · see citing works

Disorders of growth hormone resistance in childhood

Laron, Z. (1993) · The Journal of Pediatrics · doi:10.1097/00008480-199308000-00018 · Cited by 15 · see citing works

Growth hormone therapy for adult growth hormone deficiency

Shalet, S. M., Rahim, A., & Toogood, A. A. (1996) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(96)00130-0 · Cited by 14 · see citing works

High dose intravenous, but not low dose subcutaneous, insulin-like growth factor-I therapy induces sustained insulin sensitivity in severely resistant type I diabetes mellitus

Usala, A. L. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.2.435 · Cited by 8 · see citing works

Risks and Benefits of Insulin-like Growth Factor

Malozowski, S., & Stadel, B. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-7-199410010-00017 · Cited by 7 · see citing works

[Insulin-like growth factors and their receptors].

Am, S. (1990) · PubMed · Cited by 4 · see citing works

Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus

Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295 · see citing works

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis

Noto, H., Goto, A., Tsujimoto, T., & Noda, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033411 · Cited by 566 · see citing works

Diabetes Mellitus and the Risk of Cancer: Results From a Large-Scale Population-Based Cohort Study in Japan

Inoue, M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.17.1871 · Cited by 561 · see citing works

Effects of exercise and diet on chronic disease

Roberts, C. K., & Barnard, R. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00852.2004 · Cited by 556 · see citing works

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308767101 · Cited by 505 · see citing works

Visceral adiposity, insulin resistance and cancer risk

Donohoe, C. L., Doyle, S. L., & Reynolds, J. V. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-12 · Cited by 247 · see citing works

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Ahmad, S. S., Ahmad, K., Lee, E. J., Lee, Y.-H., & Choi, I. (2020) · Cells · doi:10.3390/cells9081773 · Cited by 202 · see citing works

Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma

Haluska, P., Worden, F., Olmos, D., Yin, D., Schteingart, D., Batzel, G. N., Paccagnella, M. L., de Bono, J. S., Gualberto, A., & Hammer, G. D. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1083-9 · Cited by 197 · see citing works

Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation

Heemskerk, V. H., Daemen, M. A. R. C., & Buurman, W. A. (1999) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00022-7 · Cited by 182 · see citing works

Insulin-like growth factor (IGF-I) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in a clonal skeletal-muscle cell model

SEMSARIAN, C., SUTRAVE, P., RICHMOND, D. R., & GRAHAM, R. M. (1999) · Biochemical Journal · doi:10.1042/bj3390443 · Cited by 106 · see citing works

Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

Larsson, S. C., Spyrou, N., & Mantzoros, C. S. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155326 · Cited by 89 · see citing works

The role of insulin and insulin-like growth factor-I in mammalian ageing

Richardson, A., Liu, F., Adamo, M. L., Remmen, H. V., & Nelson, J. F. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.02.002 · Cited by 64 · see citing works

Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging

Maity, P., Singh, K., Krug, L., Koroma, A., Hainzl, A., Bloch, W., Kochanek, S., Wlaschek, M., Schorpp-Kistner, M., Angel, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109634 · Cited by 56 · see citing works

Insulin: the other anabolic hormone of puberty

Caprio, S. (1999) · Acta Paediatrica · doi:10.1111/j.1651-2227.1999.tb14410.x · Cited by 55 · see citing works

Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment

de la Garza, R. G., Morales-Garza, L. A., Martin-Estal, I., & Castilla-Cortazar, I. (2017) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2761w · Cited by 55 · see citing works

Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells

XIE, Y., WANG, J.-L., JI, M., YUAN, Z.-F., PENG, Z., ZHANG, Y., WEN, J.-G., & SHI, H.-R. (2014) · Oncology Letters · doi:10.3892/ol.2014.2466 · Cited by 46 · see citing works

DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes

Kim, E., Kwak, S. H., Chung, H. R., Ohn, J. H., Bae, J. H., Choi, S. H., Park, K. S., Hong, J.-S., Sung, J., & Jang, H. C. (2017) · Epigenetics · doi:10.1080/15592294.2017.1370172 · Cited by 36 · see citing works

Revealing the Potency of Growth Factors in Bovine Colostrum

Yalçıntaş, Y. M., Duman, H., López, J. M. M., Portocarrero, A. C. M., Lombardo, M., Khallouki, F., Koch, W., Bordiga, M., El-Seedi, H., Raposo, A., et al. (2024) · Nutrients · doi:10.3390/nu16142359 · Cited by 31 · see citing works

Decline in circulating insulin-like growth factors and mortality in older adults: cardiovascular health study all-stars study

Kaplan, R. C., Bùžková, P., Cappola, A. R., Strickler, H. D., McGinn, A. P., Mercer, L. D., Arnold, A. M., Pollak, M. N., & Newman, A. B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2967 · Cited by 24 · see citing works

Application of a Machine Learning Technology in the Definition of Metabolically Healthy and Unhealthy Status: A Retrospective Study of 2567 Subjects Suffering from Obesity with or without Metabolic Syndrome

Masi, D., Risi, R., Biagi, F., Vasquez Barahona, D., Watanabe, M., Zilich, R., Gabrielli, G., Santin, P., Mariani, S., Lubrano, C., et al. (2022) · Nutrients · doi:10.3390/nu14020373 · Cited by 20 · see citing works

Biological activity of some insulin derivatives

Šiševa, A., Sirakov, L. M., Slaninová, J., et al. (1981) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc19810300

Effects of Insulin and Glucose on Cultured Rat Hepatocyte Gene Expression

Mooradian, A. D., & Mariash, C. N. (1987) · Diabetes · doi:10.2337/diab.36.8.938 · Cited by 23 · see citing works

The early phase of insulin release in man — a new method for quantitative analysis

Dörfler, H., Wolfram, G., & Zöllner, N. (1977) · Research in Experimental Medicine · doi:10.1007/bf01851507 · Cited by 1 · see citing works

Reduced Insulin Clearance in Normal Subjects Due to Extreme Hyperinsulinemia

Nestler, J. E., Clore, J. N., & Blackard, W. G. (1988) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198801000-00005 · Cited by 13 · see citing works

Using Dextran-encapsulated Gold Nanoparticles As Insulin Carriers to Prolong Insulin Activity

Lee, K.-C., Chen, W.-J., & Chen, Y. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0019 · Cited by 14 · see citing works