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Cited by 159Heart Rate Variability and Autonomic ControlRheumatoid Arthritis Research and TherapiesVagus Nerve Stimulation Research

Heart rate variability in patients with rheumatoid arthritis

Evrengül, Harun, Dursunoglu, Dursun, Cobankara, Veli, Polat, Bülent, Seleci, Deniz, Kabukçu, Sibel, Kaftan, Asuman, Semiz, Ender +1 more·2004·Rheumatology International
DOI 10.1007/s00296-003-0357-5
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Abstract

Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed changes in patients with RA in comparison with the normal population. Short-term analysis of HRV was performed for time-domain frequency in 42 patients with RA and 44 matched controls. In this analysis, patients displayed lower standard deviation of the mean than healthy subjects ( P<0.0001). Patients tended to display higher pNN50 and root-mean-square of successive difference values than did healthy subjects, but these differences were not statistically significant (P >0.05). In frequency domain analysis, the spectral measures of HRV showed reduced high-frequency (HF) values and an higher low-frequency (LF) values; as a result, the ratio between low and high frequencies (LF/HF), representative of sympathovagal modulation, was significantly increased (P=0.001, P=0.012, and P=0.003, respectively). Our data suggest an increase in sympathetic control of the heart rate in patients with RA. This increased sympathetic activity could play a key role in the development of ventricular tachyarrhythmias in RA and may be related to the higher incidence of sudden death in this disorder.

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  • Depressed vagus nerve activity is significantly correlated with increased morbidity and mortality in sepsis, rheumatoid arthritis, lupus, sarcoidosis, inflammatory bowel diseases, other diseases, and trauma.

    “Clinical research implicates a significant correlation between depressed vagus nerve activity and increased morbidity and mortality in sepsis, rheumatoid arthritis, lupus, sarcoidosis, inflammatory bowel diseases, other diseases, and trauma (55)(56)(57)(58)(59)(60)(61)(62)(63).”

    From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [57]

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Authors
Evrengül, H., Dursunoglu, D., Cobankara, V., Polat, B., Seleci, D., Kabukçu, S., Kaftan, A., Semiz, E., & Kilic, M.
Affiliations
Pamukkale University (TR)
Corresponding author
Evrengül, Harun
ORCID
Venue
Rheumatology International
Publisher
Springer Science and Business Media LLC
Published
2003-09-11
Volume
24
Issue
4
Pages
198-202
ISSN
  • 0172-8172 (ISSN-L)
  • 1437-160X
DOI
10.1007/s00296-003-0357-5
OpenAlex
W1979332100
Cited by
159
References
27
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 21 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 9 · 2012: 10
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Rheumatology International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
heart rate variability, rheumatoid arthritis, autonomic nervous system, sympathetic activity, sympathovagal balance, LF/HF ratio, ventricular tachyarrhythmia, sudden death, pNN50, spectral analysis
MeSH terms
Arrhythmias, Cardiac, Arthritis, Rheumatoid, Female, Heart Rate, Humans, Male, Middle Aged, Parasympathetic Nervous System, Electrocardiography, Ambulatory

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