Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis
Open accessAbstract
Rheumatoid arthritis (RA) is a chronic immuno-mediated disease primarily affecting the joints, characterized by persistent high-grade systemic inflammation. Cardiovascular morbidity and mortality are significantly increased in RA, with >50% of premature deaths attributable to cardiovascular disease. In particular, RA patients were twice as likely to experience sudden cardiac death compared with non-RA subjects, pointing to an increased propensity to develop malignant ventricular arrhythmias. Indeed, ventricular repolarization (QT interval) abnormalities and cardiovascular autonomic nervous system dysfunction, representing two well-recognized risk factors for life-threatening ventricular arrhythmias in the general population, are commonly observed in RA. Moreover, large population-based studies seem to indicate that also the prevalence of atrial fibrillation is significantly higher in RA subjects than in the general population, thus suggesting that these patients are characterized by an abnormal diffuse myocardial electrical instability. Although the underlying mechanisms accounting for the pro-arrhythmogenic substrate in RA are probably intricate, the leading role seems to be played by chronic systemic inflammatory activation, able to promote arrhythmias both indirectly, by accelerating the development of ischaemic heart disease and congestive heart failure, and directly, by affecting cardiac electrophysiology. In this integrated mechanistic view, lowering the inflammatory burden through an increasingly tight control of disease activity may represent the most effective intervention to reduce arrhythmic risk in these patients. Intriguingly, these considerations could be more generally applicable to all the diseases characterized by chronic systemic inflammation, and could help elucidate the link between low-grade chronic inflammation and arrhythmic risk in the general population.
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Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,875 · see citing works
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728 · see citing works
Scott, D. L., Wolfe, F., & Huizinga, T. W. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60826-4 · Cited by 3,019 · see citing works
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252 · see citing works
Sudden Death Due to Cardiac Arrhythmias
Huikuri, H. V., Castellanos, A., & Myerburg, R. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmra000650 · Cited by 1,476 · see citing works
Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
Nattel, S., Burstein, B., & Dobrev, D. (2008) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.107.754564 · Cited by 1,124 · see citing works
Inflammation and the pathogenesis of atrial fibrillation
Hu, Y., Chen, Y., Lin, Y., & Chen, S. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.2 · Cited by 1,101 · see citing works
Yan, G., & Antzelevitch, C. (1998) · Circulation · doi:10.1161/01.cir.98.18.1928 · Cited by 992 · see citing works
Aviña-Zubieta, J. A., Thomas, J. M., Sadatsafavi, M., Lehman, A. J., & Lacaille, D. V. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200726 · Cited by 948 · see citing works
Kremers, H. M., Crowson, C. S., Nicola, P., Ballman, K. V., Roger, V. L., Jacobsen, S. J., & Gabriel, S. E. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20853 · Cited by 923 · see citing works
Roubille, C., Richer, V., Starnino, T., McCourt, C., McFarlane, A., Fleming, P., Siu, S., Kraft, J., Lynde, C., Pope, J., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206624 · Cited by 907 · see citing works
Inflammation in Atrial Fibrillation
Guo, Y., Lip, G. Y. H., & Apostolakis, S. Z. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.063 · Cited by 868 · see citing works
Nattel, S., Maguy, A., Bouter, S. L., & Yeh, Y. (2007) · Physiological Reviews · doi:10.1152/physrev.00014.2006 · Cited by 857 · see citing works
Heart rate variability: A measure of cardiac autonomic tone
Stein, P. K., Bosner, M. S., Kleiger, R. E., & Conger, B. M. (1994) · American Heart Journal · doi:10.1016/0002-8703(94)90059-0 · Cited by 719 · see citing works
What Causes Sudden Death in Heart Failure?
Tomaselli, G. F., & Zipes, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000145047.14691.db · Cited by 561 · see citing works
Anti-inflammatory therapies for cardiovascular disease
Ridker, P. M., & Lüscher, T. F. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu203 · Cited by 558 · see citing works
Albert, C. M., Ma, J., Rifai, N., Stampfer, M. J., & Ridker, P. M. (2002) · Circulation · doi:10.1161/01.cir.0000017493.03108.1c · Cited by 532 · see citing works
Falk, R. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441407 · Cited by 428 · see citing works
Mason, J. C., & Libby, P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu403 · Cited by 420 · see citing works
Role of Inflammation in Atherosclerosis Associated with Rheumatoid Arthritis
Libby, P. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.06.014 · Cited by 413 · see citing works
Sajadieh, A. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.003 · Cited by 393 · see citing works
Mortality studies in systemic lupus erythematosus. Results from a single center. I. Causes of death.
Abu‐Shakra, M., Urowitz, M. B., Gladman, D. D., & Gough, J. (1995) · PubMed · Cited by 376 · see citing works
Corticosteroids for the Prevention of Atrial Fibrillation After Cardiac Surgery
Halonen, J., Halonen, P. M., Järvinen, O., Taskinen, P., Auvinen, T., Tarkka, M. R., Hippeläinen, M., Juvonen, T. S., Hartikainen, J. E. K., & Hakala, T. (2007) · JAMA · doi:10.1001/jama.297.14.1562 · Cited by 330 · see citing works
Cardiovascular disease in rheumatoid arthritis: state of the art and future perspectives
Kitas, G. D., & Gabriel, S. E. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.142133 · Cited by 320 · see citing works
Cardiovascular Morbidity and Mortality in Rheumatoid Arthritis
Gabriel, S. E. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.06.011 · Cited by 315 · see citing works
P‐Wave Dispersion: A Novel Predictor of Paroxysmal Atrial Fibrillation
Dilaveris, P., & Gialafos, J. E. (2001) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2001.tb00101.x · Cited by 313 · see citing works
The QT syndromes: long and short
Morita, H., Wu, J., & Zipes, D. P. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61307-0 · Cited by 311 · see citing works
Heart Rate Variability in Risk Stratification of Cardiac Patients
Huikuri, H. V., & Stein, P. K. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.07.003 · Cited by 282 · see citing works
RR Interval Variability Is Inversely Related to Inflammatory Markers: The CARDIA Study
Sloan, R. P., McCreath, H., Tracey, K. J., Sidney, S., Liu, K., & Seeman, T. (2007) · Molecular Medicine · doi:10.2119/2006-00112.sloan · Cited by 264 · see citing works
Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study
Ahlehoff, O., Gislason, G., Jørgensen, C. H., Lindhardsen, J., Charlot, M. G., Olesen, J. B., Abildstrom, S. Z., Skov, L., Torp-Pedersen, C. T., & Hansen, P. R. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr285 · Cited by 250 · see citing works
Goodson, N. J., Marks, J., Lunt, M., & Symmons, D. P. M. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.034777 · Cited by 249 · see citing works
Mok, C. C., Kwok, C., Ho, L. Y., Chan, P. T., & Yip, S. F. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30277 · Cited by 248 · see citing works
Autonomic aspects of arrhythmogenesis: the enduring and the new
Verrier, R. L., & Antzelevitch, C. N. (2003) · Current Opinion in Cardiology · doi:10.1097/00001573-200401000-00003 · Cited by 208 · see citing works
Karpouzas, G. A., Malpeso, J. M., Choi, T.-Y., Li, D., Munoz, S., & Budoff, M. J. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203617 · Cited by 202 · see citing works
Risk of atrial fibrillation and stroke in rheumatoid arthritis: Danish nationwide cohort study
Lindhardsen, J., Ahlehoff, O., Gislason, G., Madsen, O. R., Olesen, J. B., Svendsen, J. H., Torp-Pedersen, C. T., & Hansen, P. R. (2012) · BMJ · doi:10.1136/bmj.e1257 · Cited by 192 · see citing works
Thomas, G., Mancini, J., Jourde‐Chiche, N., Sarlon, G., Amoura, Z., Harlé, J., Jougla, É., & Chiche, L. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38731 · Cited by 190 · see citing works
Long QT Syndrome: An Emerging Role for Inflammation and Immunity
Lazzerini, P. E., Capecchi, P. L., & Pasini, F. L. (2015) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2015.00026 · Cited by 172 · see citing works
Self-citationHeart rate variability in patients with rheumatoid arthritis
Evrengül, H., Dursunoglu, D., Cobankara, V., Polat, B., Seleci, D., Kabukçu, S., Kaftan, A., Semiz, E., & Kilic, M. (2004) · Rheumatology International · doi:10.1007/s00296-003-0357-5 · Cited by 159 · see citing works
Duncan, D. J., Yang, Z., Hopkins, P. M., Steele, D. S., & Harrison, S. M. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.02.002 · Cited by 159 · see citing works
Saba, S., Janczewski, A. M., Baker, L. C., Shusterman, V., Gursoy, E. C., Feldman, A. M., Salama, G., McTiernan, C. F., & London, B. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00733.2004 · Cited by 158 · see citing works
Rheumatoid arthritis and macrovascular disease
Alkaabi, J. (2003) · British journal of rheumatology · doi:10.1093/rheumatology/keg083 · Cited by 155 · see citing works
Atrial Fibrillation in Congestive Heart Failure
Lubitz, S. A., Benjamin, E. J., & Ellinor, P. T. (2010) · Heart Failure Clinics · doi:10.1016/j.hfc.2009.11.001 · Cited by 149 · see citing works
Impairment of HERG K+ Channel Function by Tumor Necrosis Factor-α
Wang, J., Wang, H., Zhang, Y., Gao, H., Nattel, S., & Wang, Z. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400025200 · Cited by 146 · see citing works
Excess recurrent cardiac events in rheumatoid arthritis patients with acute coronary syndrome
Douglas, K., Pace, A. V., Treharne, G. J., Saratzis, A. N., Nightingale, P., Erb, N., Banks, M. J., & Kitas, G. D. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.037978 · Cited by 146 · see citing works
Sawaya, S. E., Rajawat, Y. S., Rami, T. G., Szalai, G., Price, R. L., Sivasubramanian, N., Mann, D. L., & Khoury, D. S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00285.2006 · Cited by 143 · see citing works
Kristensen, S. L., Lindhardsen, J., Ahlehoff, O., Erichsen, R., Lamberts, M., Khalid, U., Torp-Pedersen, C. T., Nielsen, O. H., Gislason, G., & Hansen, P. R. (2013) · EP Europace · doi:10.1093/europace/eut312 · Cited by 140 · see citing works
Calcium-dependent arrhythmias in transgenic mice with heart failure
London, B., Baker, L. C., Lee, J. S., Shusterman, V., Choi, B., Kubota, T., McTiernan, C. F., Feldman, A. M., & Salama, G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00431.2002 · Cited by 131 · see citing works
Ischemic ventricular arrhythmias: Experimental models and their clinical relevance
Diego, J. M. D., & Antzelevitch, C. N. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.06.036 · Cited by 125 · see citing works
Liew, R., Khairunnisa, K., Gu, Y., Tee, N., Yin, N. O., Naylynn, T. M., & Moe, K. T. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-1155 · Cited by 123 · see citing works
PORTER, K., TURNER, N., OREGAN, D., & BALL, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.07.020 · Cited by 123 · see citing works
Autonomic function and rheumatoid arthritis—A systematic review
Adlan, A., Lip, G. Y. H., Paton, J. F. R., Kitas, G. D., & Fisher, J. P. (2014) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2014.06.003 · Cited by 122 · see citing works
Doornum, S. V., Brand, C. A., King, B., & Sundararajan, V. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21932 · Cited by 119 · see citing works
Fernández‐Velasco, M., Ruiz‐Hurtado, G., Hurtado, O., Moro, M. Á., & Delgado, C. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01122.2006 · Cited by 115 · see citing works
Pena, J. M., MacFadyen, J. G., Glynn, R., & Ridker, P. M. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr460 · Cited by 115 · see citing works
Petkova-Kirova, P. S., Gursoy, E. C., Mehdi, H., McTiernan, C. F., London, B., & Salama, G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00097.2005 · Cited by 112 · see citing works
Empana, J. P., Jouven, X., Canouï‐Poitrine, F., Luc, G., Tafflet, M., Haas, B., Arveiler, D., Ferrières, J., Ruidavets, J., Montaye, M., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.208785 · Cited by 108 · see citing works
Cardiac autonomic profile in rheumatoid arthritis and systemic lupus erythematosus
Aydemir, M., Yazısız, V., Başarıcı, İ., Avci, A. B., Erbasan, F., Belgi, A., & Terzıoğlu, E. (2009) · Lupus · doi:10.1177/0961203309351540 · Cited by 107 · see citing works
Lazzerini, P. E., Acampa, M., Capecchi, P. L., Fineschi, I., Selvi, E., Moscadelli, V., Zimbone, S., Gentile, D., Galeazzi, M., & Pasini, F. L. (2014) · Arthritis Care & Research · doi:10.1002/acr.22455 · Cited by 101 · see citing works
Self-citationMantel, Ä., Holmqvist, M. E., Jernberg, T., Wållberg‐Jonsson, S., & Askling, J. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv461 · Cited by 101 · see citing works
Bruchfeld, A., Goldstein, R. S., Chavan, S., Patel, N. B., Rosas‐Ballina, M., Kohn, N., Qureshi, A. R., & Tracey, K. J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02226.x · Cited by 99 · see citing works
Hagiwara, Y., Miyoshi, S., Fukuda, K., Nishiyama, N., Ikegami, Y., Tanimoto, K., Murata, M., Takahashi, E., Shimoda, K., Hirano, T., et al. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.09.004 · Cited by 98 · see citing works
Lazzerini, P. E., Acampa, M., Guideri, F., Capecchi, P. L., Campanella, V., Morozzi, G., Galeazzi, M., Marcolongo, R., & Pasini, F. L. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20130 · Cited by 97 · see citing works
Self-citationPanoulas, V. F., Toms, T. E., Douglas, K., Sandoo, A., Metsios, G. S., Stavropoulos‐Kalinoglou, A., & Kitas, G. D. (2013) · Lara D. Veeken · doi:10.1093/rheumatology/ket338 · Cited by 92 · see citing works
Arrhythmic risk in rheumatoid arthritis: the driving role of systemic inflammation
Lazzerini, P. E., Capecchi, P. L., Acampa, M., Galeazzi, M., & Pasini, F. L. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.05.007 · Cited by 90 · see citing works
Self-citationEffects of human recombinant interleukin-1 on electrical properties of guinea pig ventricular cells
Li, Y.-H., & Rozanski, G. J. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.3.525 · Cited by 90 · see citing works
Mackey, R. H., Kuller, L. H., Deane, K. D., Walitt, B. T., Chang, Y., Holers, V. M., Robinson, W. H., Tracy, R. P., Hlatky, M. A., Eaton, C. B., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39198 · Cited by 88 · see citing works
Jesus, N. M. D., Wang, L., Herren, A. W., Wang, J., Shenasa, F., Bers, D. M., Lindsey, M. L., & Ripplinger, C. M. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.10.007 · Cited by 81 · see citing works
Hussein, A. A., Gottdiener, J. S., Bartz, T. M., Sotoodehnia, N., deFilippi, C. R., See, V. Y., Deo, R., Siscovick, D. S., Stein, P. K., & Lloyd‐Jones, D. M. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.07.004 · Cited by 72 · see citing works
Association between corrected QT interval and inflammatory cytokines in rheumatoid arthritis
Adlan, A. M., Panoulas, V. F., Smith, J. P., Fisher, J. P., & Kitas, G. D. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.140861 · Cited by 71 · see citing works
Diabetes mellitus and risk of sudden cardiac death: a systematic review and meta-analysis
Zaccardi, F., Khan, H., & Laukkanen, J. A. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.105 · Cited by 69 · see citing works
Lazzerini, P. E., Acampa, M., Capecchi, P. L., Hammoud, M., Maffei, S., Bisogno, S., Barreca, C., Galeazzi, M., & Pasini, F. L. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.02.009 · Cited by 69 · see citing works
Self-citationKawada, H., Niwano, S., Niwano, H., Yumoto, Y., Wakisaka, Y., Yuge, M., Kawahara, K., & Izumi, T. (2006) · Circulation Journal · doi:10.1253/circj.70.605 · Cited by 66 · see citing works
Arrhythmogenicity of Anti-Ro/SSA Antibodies in Patients With Torsades de Pointes
Lazzerini, P. E., Yue, Y., Srivastava, U., Fabris, F., Capecchi, P. L., Bertolozzi, I., Bacarelli, M. R., Morozzi, G., Acampa, M., Natale, M., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003419 · Cited by 64 · see citing works
Self-citationPanama, B. K., Latour-Villamil, D., Farman, G. P., Zhao, D., Bolz, S., Kirshenbaum, L. A., & Backx, P. H. (2011) · Circulation Research · doi:10.1161/circresaha.110.229112 · Cited by 63 · see citing works
Ungprasert, P., Srivali, N., & Kittanamongkolchai, W. (2015) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12820 · Cited by 59 · see citing works
Bertino, J., Owens, R. C., Carnes, T. D., & Iannini, P. B. (2002) · Clinical Infectious Diseases · doi:10.1086/339075 · Cited by 57 · see citing works
Chiu, H., Chang, W.-L., Huang, W.-F., Wen, Y., Tsai, Y., & Tsai, T. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.06.023 · Cited by 54 · see citing works
Baum, J. R., Long, B., Cabo, C., & Duffy, H. S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00498.2011 · Cited by 54 · see citing works
Milovanović, B., Stojanovich, L., Milicevic, N., Vasić, K., Bjelakovic, B. B., & Krotin, M. (2010) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh1002026m · Cited by 52 · see citing works
Population-based study of QT interval prolongation in patients with rheumatoid arthritis.
Chauhan, K., Ackerman, M. J., Crowson, C. S., Matteson, E. L., & Gabriel, S. E. (2015) · PubMed · Cited by 50 · see citing works
Doğan, Y., Soylu, A., Eren, G. A., Poturoğlu, Ş., Dolapçıoğlu, C., Sönmez, K., Duman, H., & Sevindir, İ. (2011) · International Journal of Medical Sciences · doi:10.7150/ijms.8.540 · Cited by 50 · see citing works
Increased Incidence of Atrial Fibrillation in Patients with Rheumatoid Arthritis
Bacani, A. K., Crowson, C. S., Roger, V. L., Gabriel, S. E., & Matteson, E. L. (2015) · BioMed Research International · doi:10.1155/2015/809514 · Cited by 47 · see citing works
The risk of atrial fibrillation in patients with rheumatoid arthritis
Kim, S. C., Liu, J., & Solomon, D. H. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203343 · Cited by 47 · see citing works
Püntmann, V. O., Taylor, P. C., Barr, A., Schnackenburg, B., Jahnke, C., & Paetsch, I. (2009) · Rheumatology · doi:10.1093/rheumatology/kep426 · Cited by 46 · see citing works
van Nieuwenhoven, F. A., Hemmings, K. E., Porter, K. E., & Turner, N. A. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.03.008 · Cited by 45 · see citing works
Citalopram, QTc Prolongation, and Torsades de Pointes
Tampi, R. R., Balderas, M., Carter, K. V., Tampi, D. J., Moca, M., Knudsen, A., & May, J. T. (2014) · Psychosomatics · doi:10.1016/j.psym.2014.09.002 · Cited by 44 · see citing works
Keller, J. J., Hsu, J.-L., Lin, S.-M., Chou, C., Wang, L., Wang, J., Bai, C., & Chiou, H. (2013) · Rheumatology International · doi:10.1007/s00296-013-2912-z · Cited by 43 · see citing works
Lazzerini, P. E., Acampa, M., Hammoud, M., Maffei, S., Capecchi, P. L., Selvi, E., Bisogno, S., Guideri, F., Galeazzi, M., & Pasini, F. L. (2008) · PubMed · Cited by 39 · see citing works
Self-citationHeart rate variability is related to disease activity and smoking in rheumatoid arthritis patients
Аничков, Д. А., Shostak, N. A., & Ivanov, D. S. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01099.x · Cited by 38 · see citing works
Yu, X., Patterson, E. S., Huang, S., Garrett, M. W., & Kem, D. C. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000151930.12026.b7 · Cited by 38 · see citing works
Güler, H., Seyfeli, E., Şahin, G., Duru, M., Akgül, F., Sağlam, H., & Yalçın, F. (2007) · Rheumatology International · doi:10.1007/s00296-007-0307-8 · Cited by 38 · see citing works
Medenwald, D., Kors, J. A., Loppnow, H., Thiery, J., Kluttig, A., Nuding, S., Tiller, D., Greiser, K. H., Werdan, K., & Haerting, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095994 · Cited by 37 · see citing works
Evaluation of Tp-e interval and Tp-e/QT ratio in patients with ankylosing spondylitis
Acar, G., Yorgun, H., İnci, M. F., Akkoyun, M., Bakan, B., Nacar, A. B., Dırnak, İ., Çetin, G. Y., & Bozoğlan, O. (2014) · Modern Rheumatology · doi:10.3109/14397595.2013.854072 · Cited by 35 · see citing works
Autonomic impairment in rheumatoid arthritis
van Rensburg, D. C. J., Ker, J. A., Grant, C. C., & Fletcher, L. (2012) · International Journal of Rheumatic Diseases · doi:10.1111/j.1756-185x.2012.01730.x · Cited by 34 · see citing works
Zarain‐Herzberg, Á., Estrada‐Avilés, R., & Fragoso-Medina, J. A. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-057 · Cited by 34 · see citing works
Göldeli, Ö., Dursun, E., & Komşuoğlu, B. (1998) · PubMed · Cited by 34 · see citing works
QT dispersion and cardiac involvement in patients with rheumatoid arthritis
Cindaş, A., Gökçe-Kutsal, Y., Tokgözoğlu, L. S., & Karanfil, A. (2002) · Scandinavian Journal of Rheumatology · doi:10.1080/030097402317255327 · Cited by 33 · see citing works
Effect of Ongoing Inflammation in Rheumatoid Arthritis on P-Wave Dispersion
Yavuzkır, M., Öztürk, A., Dagli, N., Koca, S. S., Karaca, I., Balın, M., & IŁik, A. (2007) · Journal of International Medical Research · doi:10.1177/147323000703500608 · Cited by 33 · see citing works
Association between C-reactive protein and QTc interval in middle-aged men and women
Kim, E., Joo, S., Kim, J., Ahn, J.-C., Kim, J. H., Kimm, K., & Shin, C. (2006) · European Journal of Epidemiology · doi:10.1007/s10654-006-9034-9 · Cited by 33 · see citing works
Joyal, D., & Arab, D. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.01.005 · Cited by 32 · see citing works
Borman, P., Gökoğlu, F., Kocaoğlu, S., & Yorgancioglu, Z. R. (2008) · Clinical Rheumatology · doi:10.1007/s10067-008-0906-0 · Cited by 31 · see citing works
Meek, I., Vonkeman, H. E., & van de Laar, M. A. F. J. (2014) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-15-142 · Cited by 31 · see citing works
Curione, M., Aratari, A., A, S. A., Colotto, M., Barbato, M., Leone, S., A, A. T., Panetti, D., & Parlapiano, C. (2010) · Internal and Emergency Medicine · doi:10.1007/s11739-010-0382-9 · Cited by 30 · see citing works
Increased Risk of Atrial and Ventricular Arrhythmia in Long‐Lasting Psoriasis Patients
Şimşek, H., Şahin, M., Akyol, A., Akdağ, S., Özkol, H. U., Gümrükçüoğlu, H. A., & Güneş, Y. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/901215 · Cited by 30 · see citing works
Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis
Açar, G. (2014) · Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · doi:10.5543/tkda.2014.52959 · Cited by 30 · see citing works
Doornum, S. V., Bohensky, M. A., TACEY, M. A., Brand, C. A., Sundararajan, V., & Wicks, I. P. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0552-2 · Cited by 30 · see citing works
Electrocardiographic P-wave characteristics in patients with psoriasis vulgaris
Bacaksız, A., Erdoğan, E., Tasal, A., Vatankulu, M. A., Kul, Ş., Sevgili, E., Ertaş, G., Dizman, D., Onsun, N., & Uysal, Ö. (2012) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2012.744372 · Cited by 27 · see citing works
Disease-modifying anti-rheumatic drugs improve autonomic neuropathy in arthritis: DIANA study
Syngle, A., Verma, I., Krishan, P., Garg, N. B., & Syngle, V. (2014) · Clinical Rheumatology · doi:10.1007/s10067-014-2716-x · Cited by 26 · see citing works
Rheumatoid arthritis and coronary atherosclerosis: two cousins engaging in a dangerous liaison
Klingenberg, R., & Lüscher, T. F. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv489 · Cited by 26 · see citing works
Assessment of Atrial Conduction Time in Patients with Systemic Lupus Erythematosus
Doğdu, O., Yarlıoğlueş, M., Kaya, M. G., Ardıç, İ., Kılınç, Y., Elçik, D., Keleşoğlu, Ş., Akpek, M., Şahin, Ö., Cosgun, S., et al. (2011) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e318207050a · Cited by 25 · see citing works
Mitrokhin, V. M., Mladenov, M. I., & Kamkin, A. G. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.05.003 · Cited by 23 · see citing works
Clarithromycin, QTc interval prolongation and torsades de pointes : the need to study case reports
Vieweg, W. V. R., Hancox, J. C., Hasnain, M., Koneru, J. N., Gysel, M., & Baranchuk, A. M. (2013) · Therapeutic Advances in Infectious Disease · doi:10.1177/2049936113497203 · Cited by 23 · see citing works
Yadav, R. K., Gupta, R., & Deepak, K. K. (2012) · Europe PMC (PubMed Central) · Cited by 23 · see citing works
Assessment of atrial conduction time in patients with systemic lupus erythematosus.
Doğdu, O., Yarlıoğlueş, M., Kaya, M. G., et al. (2011) · PubMed · Cited by 22 · see citing works
Autonomic Nervous System Function in Rheumatoid Arthritis
Vlček, M., Rovenský, J., Eisenhofer, G., Rádiková, Ž., Penesová, A., Kerlik, J., & Imrich, R. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9805-7 · Cited by 21 · see citing works
QT Dispersion in rheumatoid arthritis patients with and without sj�gren's syndrome
Pırıldar, T., Şekuri, C., �t�k, O., & Tezcan, U. K. (2003) · Clinical Rheumatology · doi:10.1007/s10067-003-0707-4 · Cited by 21 · see citing works
Vlček, M., Rovenský, J., Blazicek, P., Rádiková, Ž., Penesová, A., Kerlik, J., Květňanský, R., & Imrich, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.026 · Cited by 19 · see citing works
Kim, H., Jeon, J., Koh, B. R., Park, S. M., & Suh, C. (2013) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12224 · Cited by 17 · see citing works
Desai, S. P., Januzzi, J. L., Pande, A. N., Pomerantsev, E. V., Resnic, F. S., Fossel, A. H., Chibnik, L. B., & Solomon, D. H. (2010) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2010.04.002 · Cited by 17 · see citing works
Ben‐Zvi, I., Goldenberg, I., Matetzky, S., Grossman, C., Elis, A., Gavrielov‐Yusim, N., & Livneh, A. (2014) · Clinical Rheumatology · doi:10.1007/s10067-014-2695-y · Cited by 16 · see citing works
Medenwald, D., Dietz, S., Tiller, D., Kluttig, A., Greiser, K. H., Loppnow, H., Thiery, J., Nuding, S., Russ, M., Fahrig, A., et al. (2014) · Open Heart · doi:10.1136/openhrt-2013-000004 · Cited by 15 · see citing works
IL-1 provokes electrical abnormalities in rat atrial myocardium
Mitrokhin, V. M., Mladenov, M. I., & Kamkin, A. G. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.08.006 · Cited by 14 · see citing works
Predictors of atherosclerosis in rheumatoid arthritis
Ahmad, S., Garg, Dhar, M., Srivastava, Biswas, D., Barthwal, P., Shirazi, & Srivastava (2012) · VASA · doi:10.1024/0301-1526/a000221 · Cited by 14 · see citing works
Interleukin-6 blockade improves autonomic dysfunction in rheumatoid arthritis.
Syngle, A., Verma, I., & Krishan, P. (2015) · PubMed · Cited by 13 · see citing works
Massive Trials to Test Inflammation Hypothesis
Couzin-Frankel, J. (2012) · Science · doi:10.1126/science.337.6099.1158 · Cited by 11 · see citing works
Medikamenten-assoziiertes Long-QT-Syndrom
Bruggisser, Bravo, R., & Bodmer (2009) · Praxis · doi:10.1024/1661-8157.98.24.1409 · Cited by 10 · see citing works
Kamal, A. K. (2007) · Neurosciences · doi:10.17712/1658-3183.1489 · Cited by 10 · see citing works
Triggering of cardiac arrhythmic events in long QT syndrome: lessons from funny bunnies
Wu, C. T., & Nattel, S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229344 · Cited by 9 · see citing works
Clarithromycin-Induced Prolonged QT Syndrome
Lai, D., Brown, G., & Macdonald, I. (1996) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v49i1.2125 · Cited by 7 · see citing works
Vilaseca-Corbera, M., Vázquez-Oliva, G., Campoamor-Cela, C., Zamora, A., Bassanyanes-Vilarrasa, J., & Massa-Puig, R. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2011.05.015 · Cited by 3 · see citing works
Vilaseca-Corbera, M., Vázquez-Oliva, G., Campoamor-Cela, C., Zamora, A., Bassanyanes-Vilarrasa, J., & Massa-Puig, R. (2011) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2011.05.019 · Cited by 3 · see citing works
Lorenzo, M. D., & Schiavo, B. (1978) · PubMed · Cited by 3 · see citing works
正純, 辻., 慎恵, 堂., 明, 山., 奈倉勇爾, 進, 高., 道信, 波., 滋正, 澤., 西成田, 進., & 博敏, 石. (1991) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.80.1673 · Cited by 2 · see citing works
[A case of anti-RNP antibody positive malignant rheumatoid arthritis with pulmonary hypertension].
Tsuji, M., Dowaki, M., Yamada, A., Nakura, Y., Takahashi, S., Hatano, M., Sawada, S., Nishinarita, S., & Ishikawa, H. (1991) · PubMed · Cited by 2 · see citing works
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Cardioimmunology: the immune system in cardiac homeostasis and disease
Świrski, F. K., & Nahrendorf, M. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0065-8 · Cited by 853 · see citing works
Targher, G., Byrne, C. D., & Tilg, H. (2020) · Gut · doi:10.1136/gutjnl-2020-320622 · Cited by 848 · see citing works
Inflammation – Cause or Consequence of Heart Failure or Both?
Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 475 · see citing works
Pathophysiology of Takotsubo Syndrome
Lyon, A. R., Citro, R., Schneider, B., Morel, O., Ghadri, J. R., Templin, C., & Ömerovic, E. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.060 · Cited by 400 · see citing works
Risk of cardiomyopathy and cardiac arrhythmias in patients with nonalcoholic fatty liver disease
Anstee, Q. M., Mantovani, A., Tilg, H., & Targher, G. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0010-0 · Cited by 310 · see citing works
Dobrev, D., Heijman, J., Hiram, R., Li, N., & Nattel, S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00759-w · Cited by 272 · see citing works
COVID-19, Arrhythmic Risk, and Inflammation
Lazzerini, P. E., Boutjdir, M., & Capecchi, P. L. (2020) · Circulation · doi:10.1161/circulationaha.120.047293 · Cited by 256 · see citing works
Self-citationInflammation and atrial fibrillation: A comprehensive review
Korantzopoulos, P. G., Letsas, Κ. P., Tse, G., Fragakis, N., Goudis, C. A., & Liu, T. (2018) · Journal of Arrhythmia · doi:10.1002/joa3.12077 · Cited by 230 · see citing works
Implications of Angiogenesis Involvement in Arthritis
MacDonald, I. J., Liu, S., Su, C., Wang, Y., Tsai, C., & Tang, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072012 · Cited by 211 · see citing works
Lazzerini, P. E., Pasini, F. L., Acampa, M., Srivastava, U., Bertolozzi, I., Giabbani, B., Finizola, F., Vanni, F., Dokollari, A., Natale, M., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.011006 · Cited by 193 · see citing works
Self-citationTherapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy
Chelko, S. P., Asimaki, A., Lowenthal, J., Bueno-Beti, C., Bedja, D., Scalco, A., Amat-Alarcon, N., Andersen, P., Judge, D. P., Tung, L., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.040676 · Cited by 192 · see citing works
Yue, Y., Wang, C., Benedict, C., Huang, G., Truongcao, M. M., Roy, R., Cimini, M., Garikipati, V. N. S., Cheng, Z. A., Koch, W. J., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315829 · Cited by 175 · see citing works
Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies
Lazzerini, P. E., Pasini, F. L., Boutjdir, M., & Capecchi, P. L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0098-z · Cited by 170 · see citing works
Self-citationDherange, P., Lang, J. P., Qian, P. C., Oberfeld, B., Sauer, W. H., Koplan, B. A., & Tedrow, U. B. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.08.002 · Cited by 163 · see citing works
Systemic effects of IL-17 in inflammatory arthritis
Beringer, A., & Miossec, P. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0243-5 · Cited by 152 · see citing works
Evidence for Inflammation as a Driver of Atrial Fibrillation
Zhou, X., & Dudley, S. C. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00062 · Cited by 151 · see citing works
Role of Inflammation in the Pathogenesis of Atrial Fibrillation
Ihara, K., & Sasano, T. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.862164 · Cited by 146 · see citing works
Aromolaran, A. S., Srivastava, U., Alì, A., Chahine, M., Lazaro, D. M., El‐Sherif, N., Capecchi, P. L., Pasini, F. L., Lazzerini, P. E., & Boutjdir, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208321 · Cited by 143 · see citing works
Self-citationCardiac Fibrosis and Arrhythmogenesis
Nguyen, M., Kiriazis, H., Gao, X., & Du, X. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160046 · Cited by 151 · see citing works
miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis
Tavasolian, F., Hosseini, A. Z., Soudi, S., & Naderi, M. (2020) · Current Gene Therapy · doi:10.2174/1566523220666200916120708 · Cited by 125 · see citing works
Implications of Inflammation and Fibrosis in Atrial Fibrillation Pathophysiology
Harada, M., & Nattel, S. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.11.002 · Cited by 126 · see citing works
Luo, H., & Zhang, R. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9504 · Cited by 121 · see citing works
Systemic inflammation as a novel QT-prolonging risk factor in patients with torsades de pointes
Lazzerini, P. E., Pasini, F. L., Bertolozzi, I., Morozzi, G., Lorenzini, S., Simpatico, A., Selvi, E., Bacarelli, M. R., Finizola, F., Vanni, F., et al. (2017) · Heart · doi:10.1136/heartjnl-2016-311079 · Cited by 119 · see citing works
Self-citationLazzerini, P. E., Abbate, A., Boutjdir, M., & Capecchi, P. L. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.12.004 · Cited by 118 · see citing works
Self-citationEmerging Arrhythmic Risk of Autoimmune and Inflammatory Cardiac Channelopathies
Lazzerini, P. E., Capecchi, P. L., El‐Sherif, N., Pasini, F. L., & Boutjdir, M. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.010595 · Cited by 117 · see citing works
Self-citationNonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia
Chen, Z., Liu, J., Zhou, F., Li, H., Zhang, X., She, Z., Lu, Z., Cai, J., & Li, H. (2021) · Circulation Research · doi:10.1161/circresaha.121.319059 · Cited by 108 · see citing works
Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
Baena-Díez, J. M., García-Gil, M., Comas‐Cufí, M., Ramos, R., Prieto‐Alhambra, D., Salvador-González, B., Elosúa, R., Degano, I. R., Peñafiel, J., & Grau, M. (2017) · Heart · doi:10.1136/heartjnl-2017-311279 · Cited by 102 · see citing works
Bain, K. A., McDonald, E., Moffat, F., Tutino, M., Castelino, M., Barton, A. C., Cavanagh, J., Ijaz, U. Z., Siebert, S., McInnes, I. B., et al. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18008 · Cited by 96 · see citing works
Air Pollution and Cardiac Arrhythmias: A Comprehensive Review
Shahrbaf, M. A., Akbarzadeh, M. A., Tabary, M., & Khaheshi, I. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100649 · Cited by 91 · see citing works
Okoth, K., Wang, J., Zemedikun, D., Thomas, G., Nirantharakumar, K., & Adderley, N. (2021) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16692 · Cited by 88 · see citing works
Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future
Omran, F., Kyrou, I., Osman, F., Lim, V. G., Randeva, H. S., & Chatha, K. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105680 · Cited by 89 · see citing works
Inflammatory cytokines and cardiac arrhythmias: the lesson from COVID-19
Lazzerini, P. E., Pasini, F. L., Boutjdir, M., & Capecchi, P. L. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00714-3 · Cited by 90 · see citing works
Self-citationThe degree of hepatic steatosis associates with impaired cardiac and autonomic function
Houghton, D., Zalewski, P., Hallsworth, K., Cassidy, S., Thoma, C., Avery, L., Słomko, J., Hardy, T., Burt, A. D., TINIAKOS, D. G., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.035 · Cited by 85 · see citing works
Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms
Alì, A., Boutjdir, M., & Aromolaran, A. S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01866 · Cited by 82 · see citing works
Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection
Gopal, R., Marinelli, M. A., & Alcorn, J. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570681 · Cited by 74 · see citing works
Lazzerini, P. E., Acampa, M., Laghi-Pasini, F., Bertolozzi, I., Finizola, F., Vanni, F., Natale, M., Bisogno, S., Cevenini, G., Cartocci, A., et al. (2020) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.120.008627 · Cited by 74 · see citing works
Self-citationTian, G., Sun, Y., Liu, S., Li, C., Chen, S., Qiu, R., Zhang, X., Li, Y., Li, M., & Shang, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01005 · Cited by 70 · see citing works
Cardiac damage in autoimmune diseases: Target organ involvement that cannot be ignored
Pan, S.-Y., Tian, H., Zhu, Y., Gu, W.-J., Zou, H., Wu, X.-Q., Cheng, R., & Yang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1056400 · Cited by 68 · see citing works
New Concepts in Sudden Cardiac Arrest to Address an Intractable Epidemic
Narayan, S. M., Wang, P. J., & Daubert, J. P. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.083 · Cited by 69 · see citing works
Overview of Cardiac Arrhythmias and Treatment Strategies
Kingma, J. G., Simard, C., & Drolet, B. (2023) · Pharmaceuticals · doi:10.3390/ph16060844 · Cited by 75 · see citing works
Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment
Huseynov, A., Akın, İ., Duerschmied, D., & Scharf, R. E. (2023) · Viruses · doi:10.3390/v15020389 · Cited by 65 · see citing works
Lee, K. S., Kronbichler, A., Eisenhut, M., Lee, K. H., & Shin, J. I. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.12.001 · Cited by 58 · see citing works
Rubin, G. A., Desai, A. D., Chai, Z., Wang, A., Chen, Q., Wang, A. S., Kemal, C., Baksh, H., Biviano, A., Dizon, J. M., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.6842 · Cited by 54 · see citing works
Pranata, R., Huang, I., & Raharjo, S. B. (2020) · Indian Pacing and Electrophysiology Journal · doi:10.1016/j.ipej.2020.08.001 · Cited by 50 · see citing works
Left Atrial Cardiomyopathy – A Challenging Diagnosis
Kreimer, F., & Gotzmann, M. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.942385 · Cited by 53 · see citing works
The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
Chen, M., Li, X., Wang, S., Yu, L., Tang, J., & Zhou, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01113 · Cited by 46 · see citing works
COVID-19 and Cardiac Arrhythmias: a Contemporary Review
Saha, S. A., Russo, A. M., Chung, M. K., Deering, T. F., Lakkireddy, D., & Gopinathannair, R. (2022) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-022-00964-3 · Cited by 44 · see citing works
COVID-19 mRNA Vaccines: The Molecular Basis of Some Adverse Events
Giannotta, G., Murrone, A., & Giannotta, N. (2023) · Vaccines · doi:10.3390/vaccines11040747 · Cited by 43 · see citing works
Ba, W., Xu, W., Deng, Z., Zhang, B., Zheng, L., & Li, H. (2023) · Nutrients · doi:10.3390/nu15214652 · Cited by 43 · see citing works
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis
Li, W., Wang, X., Diao, H., Yang, Y., Ding, L., Huan, W., Chen, Y., & Cui, W. (2024) · Inflammation Research · doi:10.1007/s00011-024-01959-5 · Cited by 42 · see citing works
Leuschner, F., & Nahrendorf, M. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz159 · Cited by 42 · see citing works
Lionetti, V., Bollini, S., Coppini, R., Gerbino, A., Ghigo, A., Iaccarino, G., Madonna, R., Mangiacapra, F., Miragoli, M., Moccia, F. D., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105581 · Cited by 44 · see citing works
Predictors of electrocardiographic QT interval prolongation in men with HIV
Wu, K. C., Zhang, L., Haberlen, S. A., Ashikaga, H., Brown, T. T., Budoff, M. J., D’Souza, G., Kingsley, L. A., Palella, F. J., Margolick, J. B., et al. (2019) · Heart · doi:10.1136/heartjnl-2018-313667 · Cited by 40 · see citing works
Lazzerini, P. E., Acampa, M., Cupelli, M., Gamberucci, A., Srivastava, U., Nanni, C., Bertolozzi, I., Vanni, F., Frosali, A., Cantore, A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022095 · Cited by 41 · see citing works
Self-citationZhou, S., Zhao, G., Chen, R., Li, Y., Huang, J., Kuang, L., Zhang, D., Li, Z., Xu, H., Xiang, W., et al. (2023) · Theranostics · doi:10.7150/thno.90940 · Cited by 43 · see citing works
Proton Pump Inhibitors and Serum Magnesium Levels in Patients With Torsades de Pointes
Lazzerini, P. E., Bertolozzi, I., Finizola, F., Acampa, M., Natale, M., Vanni, F., Fulceri, R., Gamberucci, A., Rossi, M., Giabbani, B., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00363 · Cited by 40 · see citing works
Self-citationSudden cardiac death in patients with rheumatoid arthritis
Masoud, S., Lim, P. B., Kitas, G. D., & Panoulas, V. F. (2017) · World Journal of Cardiology · doi:10.4330/wjc.v9.i7.562 · Cited by 38 · see citing works
Saeedi‐Boroujeni, A., Purrahman, D., Shojaeian, A., Poniatowski, Ł. A., Rafiee, F., & Mahmoudian‐Sani, M. (2023) · Journal of Inflammation · doi:10.1186/s12950-023-00327-0 · Cited by 39 · see citing works
Chen, P., Tang, Y., He, W., Yang, R., Lan, Z., Chen, R., & Zhang, P. (2022) · Mediators of Inflammation · doi:10.1155/2022/7137900 · Cited by 39 · see citing works
Xue, X., Hu, J., Xiang, D., Li, H., Jiang, Y., Fang, W., Yan, H., Chen, J., Wang, W., Su, X., et al. (2023) · Canadian Medical Association Journal · doi:10.1503/cmaj.220929 · Cited by 37 · see citing works
Kobayashi, H., Kobayashi, Y., Yokoe, I., Kitamura, N., Nishiwaki, A., Takei, M., & Giles, J. T. (2018) · The Journal of Rheumatology · doi:10.3899/jrheum.180065 · Cited by 37 · see citing works
Zhang, S., Lu, W., Wei, Z., & Zhang, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.736151 · Cited by 38 · see citing works
Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders
Plastiras, S. C., & Moutsopoulos, H. Μ. (2021) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2020.43 · Cited by 35 · see citing works
Editorial: Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
Lazzerini, P. E., Hamilton, R. M., & Boutjdir, M. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00181 · Cited by 34 · see citing works
Self-citationDing, E., Deng, F., Fang, J., Liu, J., Yan, W., Yao, Q., Miao, K., Wang, Y., Sun, P., Li, C., et al. (2024) · Environmental Health Perspectives · doi:10.1289/ehp13864 · Cited by 33 · see citing works
Im, S. I., Heo, J., Kim, B., Cho, K. I., Kim, H. S., Heo, J. H., & Hwang, J. (2018) · Open Heart · doi:10.1136/openhrt-2017-000708 · Cited by 33 · see citing works
Proinflammatory cytokines and ageing of the cardiovascular-renal system
Smykiewicz, P., Segiet, A., Keag, M., & Żera, T. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.006 · Cited by 32 · see citing works
Distinct origins and functions of cardiac orthotopic macrophages
Wang, Z., Lu, Y., Zhao, W., Zhong, J., Lin, X., Sun, Z., He, Y., Miao, C., & Zheng, L. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-019-0769-3 · Cited by 33 · see citing works
The association of coagulation and atrial fibrillation: a systematic review and meta-analysis
Tilly, M. J., Geurts, S., Pezzullo, A. M., Bramer, W. M., de Groot, N. M. S., Kavousi, M., & de Maat, M. P. M. (2022) · EP Europace · doi:10.1093/europace/euac130 · Cited by 33 · see citing works
Tang, Y., Jiao, Y., An, X., Tu, Q., & Jiang, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117476 · Cited by 32 · see citing works
Cardiovascular system changes in rheumatoid arthritis patients with continued low disease activity
Biskup, M., Biskup, W., Majdan, M., & Targońska‐Stępniak, B. (2018) · Rheumatology International · doi:10.1007/s00296-018-4053-x · Cited by 31 · see citing works
Ventricular Fibrillation Storm in Coronavirus 2019
Elsaid, O., McCullough, P. A., Tecson, K. M., Williams, R. S., & Yoon, A. D. H. (2020) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2020.08.033 · Cited by 30 · see citing works
Lazzerini, P. E., Cevenini, G., Qu, Y. S., Fabris, F., El‐Sherif, N., Acampa, M., Cartocci, A., Pasini, F. L., Capecchi, P. L., Boutjdir, M., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.018735 · Cited by 30 · see citing works
Self-citationAcampa, M., Lazzerini, P. E., Guideri, F., Tassi, R., Monaco, A. L., & Martini, G. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.04.294 · Cited by 29 · see citing works
Self-citationKariki, O. K., Antoniou, C. K., Mavrogeni, S. I., & Gatzoulis, K. A. (2020) · Diagnostics · doi:10.3390/diagnostics10080541 · Cited by 29 · see citing works
Nerve–macrophage interactions in cardiovascular disease
Fujiu, K., & Manabe, I. (2021) · International Immunology · doi:10.1093/intimm/dxab036 · Cited by 29 · see citing works
Geraldino-Pardilla, L. B., Gartshteyn, Y., Piña, P., Cerrone, M., Giles, J. T., Zartoshti, A., Bathon, J. M., & Askanase, A. (2016) · Lupus Science & Medicine · doi:10.1136/lupus-2016-000168 · Cited by 29 · see citing works
Interactions between atrial fibrosis and inflammation in atrial fibrillation
Pang, Z., Ren, Y., & Yao, Z. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1578148 · Cited by 31 · see citing works
Mechanistic Insights Into Inflammation-Induced Arrhythmias: A Simulation Study
Bi, X., Zhang, S., Jiang, H., Ma, W., Li, Y., Lu, W., Yang, F., & Wei, Z. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.843292 · Cited by 28 · see citing works
Simpson, E. L., Benedetto, A. D., Boguniewicz, M., Ong, P. Y., Lussier, S. J., Villarreal, M., Schneider, L. C., Paller, A. S., Guttman‐Yassky, E., Hanifin, J. M., et al. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.04.052 · Cited by 28 · see citing works
Sun, J., Roelstraete, B., Svennberg, E., Halfvarson, J., Sundström, J., Forss, A., Olén, O., & Ludvigsson, J. F. (2023) · PLoS Medicine · doi:10.1371/journal.pmed.1004305 · Cited by 28 · see citing works
Capecchi, P. L., Pasini, F. L., El‐Sherif, N., Qu, Y., Boutjdir, M., & Lazzerini, P. E. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2019.02.017 · Cited by 27 · see citing works
Self-citationWang, Z., Tong, Z., Chen, H., Nie, G., Hu, J., Liu, W., Wang, E., Yuan, B., Wang, Z., & Hu, J. (2023) · Photoacoustics · doi:10.1016/j.pacs.2023.100458 · Cited by 26 · see citing works
Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission
Bornaun, H., Yılmaz, N., Kutluk, G., Dedeoğlu, R., Öztarhan, K., Keskindemirci, G., Tulunoğlu, A., & Şap, F. (2017) · BioMed Research International · doi:10.1155/2017/6960810 · Cited by 26 · see citing works
Cardiac Fibrosis and Arrhythmogenesis
Nguyen, M., Kiriazis, H., Gao, X., & Du, X. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00771.x · Cited by 25 · see citing works
The Quest for Antiinflammatory and Immunomodulatory Strategies in Heart Failure
Linthout, S. V., & Tschöpe, C. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1637 · Cited by 25 · see citing works
The Critical Roles of Proteostasis and Endoplasmic Reticulum Stress in Atrial Fibrillation
Sirish, P., Diloretto, D. A., Thai, P. N., & Chiamvimonvat, N. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.793171 · Cited by 25 · see citing works
Androgen Deprivation Therapy for Prostatic Cancer in Patients With Torsades de Pointes
Lazzerini, P. E., Bertolozzi, I., Acampa, M., Cantara, S., Castagna, M. G., Pieragnoli, L., D’Errico, A., Rossi, M., Bisogno, S., El‐Sherif, N., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00684 · Cited by 24 · see citing works
Self-citationZhan, R., Rao, L., Chen, Z., Strash, N., & Bursac, N. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.007 · Cited by 24 · see citing works
An, Z., Tian, J., Liu, Y., Zhao, X., Yang, X.-Y., Yong, J., Liu, L., Zhang, L.-J., Jiang, W.-J., Song, X.-T., et al. (2022) · Aging and Disease · doi:10.14336/ad.2022.0416 · Cited by 20 · see citing works
Targońska‐Stępniak, B., Biskup, M., Biskup, W., & Majdan, M. (2019) · BioMed Research International · doi:10.1155/2019/3265847 · Cited by 24 · see citing works
He, F., Yanosky, J. D., Fernández‐Mendoza, J., Chinchilli, V. M., Al‐Shaar, L., Vgontzas, A. N., Bixler, E. O., & Liao, D. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026370 · Cited by 22 · see citing works
Marked QTc Prolongation and Torsades de pointes in Patients with Chronic Inflammatory Arthritis
Lazzerini, P. E., Capecchi, P. L., Bertolozzi, I., Morozzi, G., Lorenzini, S., Simpatico, A., Selvi, E., Bacarelli, M. R., Acampa, M., Lazaro, D. M., et al. (2016) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2016.00031 · Cited by 23 · see citing works
Self-citationAntiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction
Liang, B., Zhou, Y., Fu, L., & Liao, H.-L. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/9185707 · Cited by 23 · see citing works
Emerging biomarkers for cardiac arrhythmias.
Hammerer-Lercher, A., Namdar, M., & Vuilleumier, N. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.11.012 · Cited by 20 · see citing works
Carotid Intima‐Media Thickness and the Risk of Sudden Cardiac Death: The ARIC Study and the CHS
Suzuki, T., Wang, W., Wilsdon, A., Butler, K. R., Adabağ, S., Griswold, M. E., Nambi, V., Rosamond, W. D., Sotoodehnia, N., & Mosley, T. H. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016981 · Cited by 22 · see citing works
Gatti, M., Raschi, E., Poluzzi, E., Martignani, C., Salvagni, S., Ardizzoni, A., & Diemberger, I. (2020) · Current Heart Failure Reports · doi:10.1007/s11897-020-00485-9 · Cited by 22 · see citing works
Wang, X., Fan, H., Wang, Y., Xufang, Y., Liu, G., Gao, C., Li, X., & Liang, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.744254 · Cited by 22 · see citing works
Bennett, M. T., Nault, I., Koehle, M. S., & Wilton, S. B. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.03.023 · Cited by 22 · see citing works
Han, X., Gao, Y., He, M., Luo, Y., Wei, Y., Duan, Y., Zhang, S., Yu, H., Kan, J., Hou, T., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.09.007 · Cited by 22 · see citing works
- Authors
- Lazzerini, P. E., Capecchi, P. L., & Laghi-Pasini, F.
- Affiliations
- University of Siena (IT)
- Corresponding author
- Lazzerini, Pietro Enea
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06-01
- Volume
- 38
- Issue
- 22
- Pages
- ehw208
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2413246133
- Cited by
- 299
- References
- 134
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 37 · 2023: 29 · 2022: 36 · 2021: 40 · 2020: 48 · 2019: 35 · 2018: 28 · 2017: 11 · 2016: 7
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Use Siena air (University of Siena) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- rheumatoid arthritis, systemic inflammation, ventricular arrhythmias, sudden cardiac death, atrial fibrillation, cardiac autonomic dysfunction, cardiovascular disease, disease activity control, myocardial electrical instability, ischemic heart disease, congestive heart failure
- MeSH terms
- Arrhythmias, Cardiac, Arthritis, Rheumatoid, Electrocardiography, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Myocardial Infarction, Myocarditis, Risk Factors, Cytokines, Death, Sudden, Cardiac, Myocytes, Cardiac
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