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Cited by 543

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis

Open access
Bohte, Anneloes E., van Werven, Jochem R., Bipat, Shandra, Stoker, Jaap·2011·European Radiology

Abstract

OBJECTIVE: To meta-analyse the diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis. METHODS: From a comprehensive literature search in MEDLINE, EMBASE, CINAHL and Cochrane (up to November 2009), articles were selected that investigated the diagnostic performance imaging techniques for evaluating hepatic steatosis with histopathology as the reference standard. Cut-off values for the presence of steatosis on liver biopsy were subdivided into four groups: (1) >0, >2 and >5% steatosis; (2) >10, >15 and >20%; (3) >25, >30 and >33%; (4) >50, >60 and >66%. Per group, summary estimates for sensitivity and specificity were calculated. The natural-logarithm of the diagnostic odds ratio (lnDOR) was used as a single indicator of test performance. RESULTS: 46 articles were included. Mean sensitivity estimates for subgroups were 73.3-90.5% (US), 46.1-72.0% (CT), 82.0-97.4% (MRI) and 72.7-88.5% (1H-MRS). Mean specificity ranges were 69.6-85.2% (US), 88.1-94.6% (CT), 76.1-95.3% (MRI) and 92.0-95.7% (1H-MRS). Overall performance (lnDOR) of MRI and 1H-MRS was better than that for US and CT for all subgroups, with significant differences in groups 1 and 2. CONCLUSION: MRI and 1H-MRS can be considered techniques of choice for accurate evaluation of hepatic steatosis.

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Metadata

Authors
Bohte, A. E., van Werven, J. R., Bipat, S., & Stoker, J.
Venue
European Radiology
Published
2010-07-31
Volume
21
Issue
1
Pages
87-97
ISSN
  • 0938-7994 (ISSN-L)
  • 1432-1084
OpenAlex
W2128682609
Cited by
543
References
5
FWCI
2.18
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis. https://app.cochat.ai/papers/10.1007/s00330-010-1905-5
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Bohte, A. E., van Werven, J. R., Bipat, S., & Stoker, J. (2011). The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis. European Radiology. https://doi.org/10.1007/s00330-010-1905-5

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