One step further into the blackbox: A pilot study of how to build more confidence around an AI-based decision system of breast nodule assessment in 2D ultrasound
Abstract
Objectives To investigate how a DL model makes decisions in lesion classification with a newly defined region of evidence (ROE) by incorporating "explainable AI" (xAI) techniques.Methods A data set of 785 2D breast ultrasound images acquired from 367 females. The DenseNet-121 was used to classify whether the lesion is benign or malignant. For performance assessment, classification results are evaluated by calculating accuracy, sensitivity, specificity, and receiver operating characteristic for experiments of both coarse and fine regions of interest (ROIs). The area under the curve (AUC) was evaluated, and the true-positive, false-positive, true-negative, and false-negative results with breakdown in high, medium, and low resemblance on test sets were also reported.Results The two models with coarse and fine ROIs of ultrasound images as input achieve an AUC of 0.899 and 0.869, respectively. The accuracy, sensitivity, and specificity of the model with coarse ROIs are 88.4%, 87.9%, and 89.2%, and with fine ROIs are 86.1%, 87.9%, and 83.8%, respectively. The DL model captures ROE with high resemblance of physicians' consideration as they assess the image.Conclusions We have demonstrated the effectiveness of using DenseNet to classify breast lesions with limited quantity of 2D grayscale ultrasound image data. We have also proposed a new ROE-based metric system that can help physicians and patients better understand how AI makes decisions in reading images, which can potentially be integrated as a part of evidence in early screening or triaging of patients undergoing breast ultrasound examinations.Key points • The two models with coarse and fine ROIs of ultrasound images as input achieve an AUC of 0.899 and 0.869, respectively. The accuracy, sensitivity, and specificity of the model with coarse ROIs are 88.4%, 87.9%, and 89.2%, and with fine ROIs are 86.1%, 87.9%, and 83.8%, respectively. • The first model with coarse ROIs is slightly better than the second model with fine ROIs according to these evaluation metrics. • The results from coarse ROI and fine ROI are consistent and the peripheral tissue is also an impact factor in breast lesion classification.
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Dong et al. promoted the importance of an increased confidence in AI assistance in health care, which can be addressed by understanding the algorithm of the black box and encouraging the concept of 'explainable AI'.
“Dong et al. promoted the importance of an increased confidence in AI assistance in health care, which can be addressed by understanding the algorithm of the black box and encouraging the concept of ‘explainable AI’ [201].”
Lower accuracy in borderline findings was a limitation to AI usage in breast US.
“a lower accuracy in borderline findings [201].”
Some AI models can fail in pattern recognition tasks when subtle differences are diagnosis-relevant, e.g., in borderline findings or in small regions of interest such as endometrial thickness or fetal brain structures.
“some AI models can fail when subtle differences are diagnosis-relevant, e.g., in borderline findings or in small regions of interest such as endometrial thickness or fetal brain structures [95,201,208].”
Explainable AI is used in the studies of Sakai et al. and Dong et al.
“the concept of ‘explainable AI’, which is used in the studies of Sakai et al. and Dong et al. [7,201].”
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Süreyya, N. U. R. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1104.c4419
Metacognitive efficiency in learned value-based choice
Ershadmanesh, S., Gholamzadeh, A., Desender, K., & Dayan, P. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014108
- Authors
- Dong, F., She, R., Cui, C., Shi, S., Hu, X., Zeng, J., Wu, H., Xu, J., & Zhang, Y.
- Affiliations
- Shandong University (CN)
- Jinan University (CN)
- Corresponding author
- Xu, Jinfeng
- Zhang, Yun
- Venue
- European Radiology
- Published
- 2021-01-06
- Volume
- 31
- Issue
- 7
- Pages
- 4991-5000
- ISSN
- 0938-7994 (ISSN-L)
- 1432-1084
- OpenAlex
- W3119612737
- Cited by
- 43
- References
- 56
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 12 · 2023: 8 · 2022: 7 · 2021: 4
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Radiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Science and Technology Research Foundation of Guangdong (B2019045)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Physical Sciences › Computer Science › Artificial Intelligence › Explainable Artificial Intelligence (XAI)
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- breast ultrasound, explainable AI, DenseNet121, deep learning, benign versus malignant breast lesions, transparency in decision-making
- MeSH terms
- Artificial Intelligence, Breast, Breast Neoplasms, Female, Humans, Pilot Projects, Sensitivity and Specificity, Ultrasonography
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