Cited by 77Carcinogens and Genotoxicity AssessmentPlant Genetic and Mutation StudiesGenomics and Rare Diseases

Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited

Keays, David A., Clark, Taane G., Campbell, Thomas G., Broxholme, John, Valdar, William·2007·Mammalian Genome

Abstract

We recently described methods for estimating the number of N-ethyl-N-nitrosourea (ENU)-induced coding mutations in phenotypic and genotypic screens. In this article we revisit these methods, clarifying their application. In particular, we focus on the difference between unconditional and conditional probabilities. We also introduce a website to assist investigators in the application of these equations ( http://www.well.ox.ac.uk/enuMutRat ).

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Crossref · 10.1007/s00335-006-0065-z

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43 of 43 references verified0 citation errors · 0 not checkable

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Authors
Keays, D. A., Clark, T. G., Campbell, T. G., Broxholme, J., & Valdar, W.
Affiliations
Centre for Human Genetics (GB)
Corresponding author
Keays, David A.
Venue
Mammalian Genome
Published
2007-02
Volume
18
Issue
2
Pages
123-124
ISSN
  • 0938-8990 (ISSN-L)
  • 1432-1777
OpenAlex
W2021794729
Cited by
77
References
43
Citations by year
2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 8
FWCI
4.45
Type
journal article
Language
en
Open access
closed
Locations
  • Mammalian Genome (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
Keywords
N-ethyl-N-nitrosourea, ENU mutagenesis screen, coding mutations, mutation rate estimation, conditional probability, phenotypic screening
MeSH terms
Ethylnitrosourea, Genetic Testing, Genotype, Mutation, Phenotype, Probability, Mutagenesis

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