Leptin, leptin gene and leptin receptor gene polymorphism in heart failure with preserved ejection fraction
Abstract
Heart failure with a normal ejection fraction (HFNEF) is common in obesity and coronary artery disease (CAD). Both ischemia and reperfusion induce leptin (LEP) and leptin receptor (LEPR) gene expression. We aimed to investigate the possible associations of serum leptin, leptin gene and leptin receptor gene polymorphism with HFNEF in patients with CAD. 100 Egyptian CAD patients with HFNEF and 100 healthy subjects (the control group) were genotyped for LEP and LEPR polymorphism. Leptin levels were measured. Serum leptin levels were significantly increased in patients compared to the control group. There was a significant increase in the leptin gene (AA genotype) and the leptin receptor gene (RR genotype) in HFNEF patients compared to the control group. Leptin levels, leptin gene (AA genotype) and LEPR (RR genotype) were more associated with NYHA III than with NYHA I and II. We thus concluded that HFNEF is associated with increased serum leptin levels, and the LEP AA genotype or LEPR RR genotype carries at least a threefold increased risk of developing HFNEF.
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In CAD patients, both leptin gene (AA genotype) and leptin receptor gene (RR genotype) carried a risk that was at least tripled of developing HFpEF.
“Among inflammatory cytokines, leptin can play a relevant role as its circulating levels were correlated with EAT adiposity in T1DM patients independently of obesity, and in a study in CAD patients both leptin gene (AA genotype) and leptin receptor gene (RR genotype) carried a risk that was at least tripled of developing HFpEF [57,94].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [94]
Leptin circulating levels are correlated with EAT adiposity in T1DM patients independently of obesity.
“Among inflammatory cytokines, leptin can play a relevant role as its circulating levels were correlated with EAT adiposity in T1DM patients independently of obesity, and in a study in CAD patients both leptin gene (AA genotype) and leptin receptor gene (RR genotype) carried a risk that was at least tripled of developing HFpEF [57,94].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [94]
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- Authors
- Abd El-Aziz, T. A., Mohamed, R. H., Mohamed, R. H., & Pasha, H. F.
- Affiliations
- Zagazig University (EG)
- Venue
- Heart and Vessels
- Published
- 2011-05-17
- Volume
- 27
- Issue
- 3
- Pages
- 271-279
- ISSN
- 0910-8327 (ISSN-L)
- 1615-2573
- OpenAlex
- W1965623854
- Cited by
- 29
- References
- 50
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Heart and Vessels (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- heart failure with preserved ejection fraction, leptin, leptin receptor, leptin gene polymorphism, coronary artery disease, obesity, serum leptin, genetic susceptibility, NYHA functional class
- MeSH terms
- Adult, Aged, Analysis of Variance, Egypt, Female, Gene Frequency, Heart Failure, Humans, Lipids, Male, Middle Aged, Phenotype, Polymorphism, Genetic, Regression Analysis, Risk Factors, Severity of Illness Index, Stroke Volume, Echocardiography, Doppler, Biomarkers, Chi-Square Distribution, Odds Ratio, Case-Control Studies, Ventricular Function, Left, Risk Assessment, Genetic Predisposition to Disease, Leptin, Receptors, Leptin
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