Telomere shortening and ageing
Abstract
Telomeres form the ends of human chromosomes. Telomeres shorten with each round of cell division and this mechanism limits proliferation of human cells to a finite number of cell divisions by inducing replicative senescence, differentiation, or apoptosis. Telomere shortening can act as a tumor suppressor. However, as a downside, there is growing evidence indicating that telomere shortening also limits stem cell function, regeneration, and organ maintenance during ageing. Moreover, telomere shortening during ageing and disease is associated with increasing cancer risk. In this review we summarize our current knowledge on the role of telomere shortening in human ageing, chronic diseases, and cancer.
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Additional factors such as processing of telomeres during the cell cycle and reactive oxygen species worsen telomere shortening.
“Additional factors (processing of telomeres during the cell cycle, reactive oxygen species) also worsen telomere shortening [172].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [172]
Cites
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BackgroundTelomere Shortening Is Associated with Cell Division in Vitro and in Vivo
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Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
- Authors
- Jiang, H., Ju, Z., & Rudolph, K. L.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Universität Ulm (DE)
- Corresponding author
- Rudolph, K. L.
- Venue
- Zeitschrift für Gerontologie und Geriatrie
- Published
- 2007-10
- Volume
- 40
- Issue
- 5
- Pages
- 314-324
- ISSN
- 0948-6704 (ISSN-L)
- 1435-1269
- OpenAlex
- W2099251709
- Cited by
- 165
- References
- 11
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 17 · 2021: 14 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 6 · 2014: 18 · 2013: 9 · 2012: 6
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Zeitschrift für Gerontologie und Geriatrie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- telomere shortening, aging, replicative senescence, stem cell function, regeneration, organ maintenance, cancer risk, chronic disease, tumor suppression, apoptosis, differentiation
- MeSH terms
- Aging, Cell Division, Chronic Disease, Humans, Models, Genetic, Neoplasms, Telomere, Cellular Senescence, Genetic Predisposition to Disease
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