Cited by 123Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune ResponseGenetics, Aging, and Longevity in Model Organisms

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

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Vitlic, Ana, Lord, Janet M., Phillips, Anna C.·2014·AGE

Abstract

The immune response is essential for keeping an organism healthy and for defending it from different types of pathogens. It is a complex system that consists of a large number of components performing different functions. The adequate and controlled interaction between these components is necessary for a robust and strong immune response. There are, however, many factors that interfere with the way the immune response functions. Stress and ageing now consistently appear in the literature as factors that act upon the immune system in the way that is often damaging. This review focuses on the role of stress and ageing in altering the robustness of the immune response first separately, and then simultaneously, discussing the effects that emerge from their interplay. The special focus is on the psychological stress and the impact that it has at different levels, from the whole system to the individual molecules, resulting in consequences for physical health.

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Research works printed but not linked: 3

  1. Hussain D (2010) Stress, immunity, and health: Research findings and implications. Int J Psychosoc Rehab 15 (1):94-100
  2. Kiecolt-Glaser JK, Speicher CE, Glaser R, Dura JR, Trask OJ (1991b) Spousal caregivers of dementia victims -longitudinal changes in immunity and health. Psychosomatic Medicine 53 (4):345-362
  3. Siergist CA (2008) Vaccine immunology. In: Plotkin S, Orenstein, W., & Offit, P. (ed) Vaccines. Saunders, Elsevier, pp 17-36

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Authors
Vitlic, A., Lord, J. M., & Phillips, A. C.
Affiliations
Arthritis Research UK (GB)
Corresponding author
Phillips, Anna C.
Venue
AGE
Published
2014-02-25
Volume
36
Issue
3
Pages
9631-9631
ISSN
  • 0161-9152 (ISSN-L)
  • 1574-4647
OpenAlex
W2091660936
Cited by
123
References
199
Citations by year
2026: 8 · 2025: 11 · 2024: 14 · 2023: 12 · 2022: 9 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 5
FWCI
0.43
Type
journal article
Language
en
Open access
Locations
  • AGE (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Funders
  • Medical Research Council (MR/K00414X/1)
  • Economic and Social Research Council (ES/G037000/1, ES/H043772/1)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
psychological stress, aging, immune response, immunosenescence, stress-immune interaction, immune dysfunction, physical health
MeSH terms
Aging, Animals, Humans, Immune System, Stress, Psychological

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