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Cited by 238Nutritional Studies and DietFood composition and propertiesDiet, Metabolism, and Disease

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Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress

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Montonen, Jukka, Boeing, Heiner, Fritsche, Andreas, Schleicher, Erwin, Joost, Hans-Georg, Schulze, Matthias B., Steffen, Annika, Pischon, Tobias·2013·European Journal of Nutrition
DOI 10.1007/s00394-012-0340-6PMC PMC3549403
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Abstract

PURPOSE: To examine the association of red meat and whole-grain bread consumption with plasma levels of biomarkers related to glucose metabolism, oxidative stress, inflammation and obesity. METHODS: Our cross-sectional study was based on 2,198 men and women who were selected as a sub-cohort for an investigation of biological predictors of diabetes and cardiovascular diseases from the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Circulating levels of glycated hemoglobin, adiponectin, hs-CRP, gamma-glutamyltransferase, alanine-aminotransferase, fetuin-A, HDL-cholesterol and triglycerides were measured from random blood samples. Diet and lifestyle data were assessed by questionnaires, and anthropometric data were measured. RESULTS: After multivariable adjustment, higher consumption of whole-grain bread was significantly (P trend <0.05) associated with lower levels of GGT, ALT and hs-CRP, whereas higher consumption of red meat was significantly associated with higher levels of GGT and hs-CRP when adjusted for potential confounding factors related to lifestyle and diet. Further adjustment for body mass index and waist circumference attenuated the association between red meat and hs-CRP (P = 0.19). CONCLUSIONS: The results of this study suggest that high consumption of whole-grain bread is related to lower levels of GGT, ALT and hs-CRP, whereas high consumption of red meat is associated with higher circulating levels of GGT and hs-CRP.

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Fig. 1 Geometric means (95 % CI) of plasma hs-CRP levels across quintiles of red meat according to categories of whole-grain bread consumption [adjusted for age, sex, education (sport activity (0, 0.1–4, or >4 h/week), occupational activity (light, moderate, heavy), smoking (never, past or current <20, current 20 or more cigarettes/day), alcohol intake (0, 0.1–5, 5.1–10, 10.1–20, 20.1–40 or >40 g/day) and dietary variables (continuous): energy intake, consumptions of coffee and food items aggregating into same dietary pattern with red meat such as cabbages, cooked vegetables, legumes, cooked potatoes, mushrooms, sauce and poultry and food items aggregating into same dietary pattern with whole-grain bread, such as pasta and rice, pizza, vegetarian dishes, muesli, other bread than whole-grain bread, wine and spirits. P for interaction = 0.02]
Fig. 1 Geometric means (95 % CI) of plasma hs-CRP levels across quintiles of red meat according to categories of whole-grain bread consumption [adjusted for age, sex, education (sport activity (0, 0.1–4, or >4 h/week), occupational activity (light, moderate, heavy), smoking (never, past or current <20, current 20 or more cigarettes/day), alcohol intake (0, 0.1–5, 5.1–10, 10.1–20, 20.1–40 or >40 g/day) and dietary variables (continuous): energy intake, consumptions of coffee and food items aggregating into same dietary pattern with red meat such as cabbages, cooked vegetables, legumes, cooked potatoes, mushrooms, sauce and poultry and food items aggregating into same dietary pattern with whole-grain bread, such as pasta and rice, pizza, vegetarian dishes, muesli, other bread than whole-grain bread, wine and spirits. P for interaction = 0.02]CC BY · PubMed Central

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Metadata

Authors
Montonen, J., Boeing, H., Fritsche, A., Schleicher, E., Joost, H.-G., Schulze, M. B., Steffen, A., & Pischon, T.
Affiliations
  • German Institute of Human Nutrition (DE)
  • University of Tübingen (DE)
  • Max Delbrück Center (DE)
Corresponding author
Steffen, Annika
ORCID
Venue
European Journal of Nutrition
Publisher
Springer Science and Business Media LLC
Published
2012-03-18
Volume
52
Issue
1
Pages
337-345
ISSN
  • 1436-6207 (ISSN-L)
  • 1436-6215
DOI
10.1007/s00394-012-0340-6
PMC
PMC3549403
OpenAlex
W1982890062
Cited by
234
References
62
Citations by year
2026: 5 · 2025: 4 · 2024: 15 · 2023: 12 · 2022: 27 · 2021: 26 · 2020: 19 · 2019: 19 · 2018: 17 · 2017: 21 · 2016: 12 · 2015: 27 · 2014: 17 · 2013: 11 · 2012: 2
FWCI
17.60
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • European Journal of Nutrition (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Funders
Bundesministerium für Bildung und Forschung (0315381A)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
red meat consumption, whole grain bread, obesity biomarkers, inflammation, glucose metabolism, oxidative stress, gamma-glutamyl transferase, alanine aminotransferase, high-sensitivity C-reactive protein, adiponectin, fetuin-A, HbA1c, HDL cholesterol, triglycerides, body mass index, waist circumference, diabetes risk
MeSH terms
Alanine Transaminase, Animals, Blood Glucose, Bread, C-Reactive Protein, Cardiovascular Diseases, Cattle, Edible Grain, Cross-Sectional Studies, Diet, Female, gamma-Glutamyltransferase, Glycated Hemoglobin, Humans, Inflammation, Life Style, Cholesterol, HDL, Male, Meat, Middle Aged, Obesity, Prospective Studies, Surveys and Questionnaires, Triglycerides, Biomarkers, Body Mass Index, Oxidative Stress, Adiponectin, Waist Circumference, alpha-2-HS-Glycoprotein

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