Cited by 62Advanced Glycation End Products researchNutritional Studies and DietPotato Plant Research

Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults

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Cordova, R., Knaze, V., Viallon, V., Rust, P., Schalkwijk, C. G., Weiderpass, E., Wagner, K-H., Mayen-Chacon, A-L. +41 more·2020·European Journal of Nutrition

Abstract

Purpose Advanced glycation end products (AGEs) can be formed in foods by the reaction of reducing sugars with proteins, and have been shown to induce insulin resistance and obesity in experimental studies. We examined the association between dietary AGEs intake and changes in body weight in adults over an average of 5 years of follow-up.Methods A total of 255,170 participants aged 25-70 years were recruited in ten European countries (1992-2000) in the PANACEA study (Physical Activity, Nutrition, Alcohol, Cessation of smoking, Eating out of home in relation to Anthropometry), a sub-cohort of the EPIC (European Prospective Investigation into Cancer and Nutrition). Body weight was measured at recruitment and self-reported between 2 and 11 years later depending on the study center. A reference database for AGEs was used containing UPLC-MS/MS-measured N ε-(carboxymethyl)-lysine (CML), N ε-(1-carboxyethyl)-lysine (CEL), and N δ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) in 200 common European foods. This reference database was matched to foods and decomposed recipes obtained from country-specific validated dietary questionnaires in EPIC and intake levels of CEL, CML, and MG-H1 were estimated. Associations between dietary AGEs intake and body weight change were estimated separately for each of the three AGEs using multilevel mixed linear regression models with center as random effect and dietary AGEs intake and relevant confounders as fixed effects.Results A one-SD increment in CEL intake was associated with 0.111 kg (95% CI 0.087-0.135) additional weight gain over 5 years. The corresponding additional weight gain for CML and MG-H1 was 0.065 kg (0.041-0.089) and 0.034 kg (0.012, 0.057), respectively. The top six food groups contributing to AGEs intake, with varying proportions across the AGEs, were cereals/cereal products, meat/processed meat, cakes/biscuits, dairy, sugar and confectionary, and fish/shellfish.Conclusion In this study of European adults, higher intakes of AGEs were associated with marginally greater weight gain over an average of 5 years of follow-up.

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  • Consumption of dietary AGEs does not necessarily increase obesity based on its marginal association with increased body weight gain.

    “although consumption of dietary AGEs does not necessarily increase obesity based on its marginal association with increased body weight gain67,76.”
  • Dietary and endogenous AGEs and the AGE-RAGE interaction can promote oxidative stress and inflammation, contributing to accelerated progression of obesity-related complications.

    “Dietary and endogenous AGEs and the AGE-RAGE interaction can promote oxidative stress and inflammation, contributing to the accelerated progression of obesity-related complications such as elevated serum AGEs, insulin resistance, AGE accumulation, and elevated proinflammatory cytokines in adipose tissues67,76, although consumption of dietary AGEs does not necessarily increase obesity based on its”

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Authors
Cordova, R., Knaze, V., Viallon, V., Rust, P., Schalkwijk, C. G., Weiderpass, E., Wagner, K.-H., Mayen-Chacon, A.-L., Aglago, E. K., Dahm, C. C., Overvad, K., Tjønneland, A., Halkjær, J., Mancini, F. R., Boutron-Ruault, M.-C., Fagherazzi, G., Katzke, V., Kühn, T., Schulze, M. B., Boeing, H., Trichopoulou, A., Karakatsani, A., Thriskos, P., Masala, G., Krogh, V., Panico, S., Tumino, R., Ricceri, F., Spijkerman, A., Boer, J., Skeie, G., Rylander, C., Borch, K. B., Quirós, J. R., Agudo, A., Redondo-Sánchez, D., Amiano, P., Gómez-Gómez, J.-H., Barricarte, A., Ramne, S., Sonestedt, E., Johansson, I., Esberg, A., Tong, T., Aune, D., Tsilidis, K. K., Gunter, M. J., Jenab, M., & Freisling, H.
Affiliations
  • Centre international de recherche sur le cancer (FR)
  • University of Vienna (AT)
  • Maastricht University Medical Centre (NL)
  • Aarhus University (DK)
  • University of Copenhagen (DK)
  • Danish Cancer Society (DK)
  • Inserm (FR)
  • German Cancer Research Center (DE)
  • University of Potsdam (DE)
  • German Institute of Human Nutrition (DE)
  • Hellenic Health Foundation (GR)
  • National and Kapodistrian University of Athens (GR)
  • Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
  • Federico II University Hospital (IT)
  • University of Turin (IT)
  • National Institute for Public Health and the Environment (NL)
  • UiT The Arctic University of Norway (NO)
  • Gobierno del Principado de Asturias (ES)
  • Institut d'Investigació Biomédica de Bellvitge (ES)
  • Biogipuzkoa Health Research Institute (ES)
  • Universidad de Murcia (ES)
  • Instituto de Salud Pública de Navarra (ES)
  • Lund University (SE)
  • Umeå University (SE)
  • University of Oxford (GB)
  • Imperial College London (GB)
  • University of Ioannina (GR)
Corresponding author
Freisling, Heinz
Venue
European Journal of Nutrition
Published
2019-11-07
Volume
59
Issue
7
Pages
2893-2904
ISSN
  • 1436-6207 (ISSN-L)
  • 1436-6215
OpenAlex
W2989531702
Cited by
62
References
46
Citations by year
2026: 5 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 8 · 2021: 16 · 2020: 6
FWCI
5.16
Type
journal article
Language
en
Open access
Locations
  • European Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion, other-oa)
  • Rivm (National Institute for Public Health and the Environment) (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Funders
  • World Cancer Research Fund International (2015/1391)
  • Fondation de France (00081166, 00089811)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
Keywords
advanced glycation end products, weight change, weight gain, carboxymethyllysine, MG-H1, food composition, obesity, insulin resistance
MeSH terms
Adult, Body Weight, Chromatography, Liquid, Diet, Europe, Humans, Prospective Studies, Glycation End Products, Advanced, Tandem Mass Spectrometry

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