CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injury

Endothelial Progenitor Cells

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Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

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Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis

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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

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Late Angiographic Stent Thrombosis (LAST) Events With Drug-Eluting Stents

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All in the CCN family: essential matricellular signaling modulators emerge from the bunker

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Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

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Functions and mechanisms of action of CCN matricellular proteins

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CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

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CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity

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Cyr61, a Product of a Growth Factor-Inducible Immediate-Early Gene, Promotes Cell Proliferation, Migration, and Adhesion

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The Angiogenic Factor Cyr61 Activates a Genetic Program for Wound Healing in Human Skin Fibroblasts

Chen, C.-C., Mo, F.-E., & Lau, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107666200 · Cited by 300 · see citing works

Essential Role of ICAM-1/CD18 in Mediating EPC Recruitment, Angiogenesis, and Repair to the Infarcted Myocardium

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Endothelial progenitor cells as a new agent contributing to vascular repair

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Exercise training improves function of circulating angiogenic cells in patients with chronic heart failure

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Vascular Endothelial Growth Factor Regulates Reendothelialization and Neointima Formation in a Mouse Model of Arterial Injury

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The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration

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Expression of CYR61, an Angiogenic Immediate Early Gene, in Arteriosclerosis and Its Regulation by Angiotensin II

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Temporal Expression of the Chondrogenic and Angiogenic Growth Factor CYR61 During Fracture Repair

Hadjiargyrou, M., Ahrens, W., & Rubin, C. T. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.1014 · Cited by 110 · see citing works

Regulation of Proangiogenic Factor CCN1 in Cardiac Muscle: Impact of Ischemia, Pressure Overload, and Neurohumoral Activation

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Forkhead Transcription Factor FOXO3a Is a Negative Regulator of Angiogenic Immediate Early Gene CYR61, Leading to Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

Lee, H.-Y., Chung, J.-W., Youn, S.-W., Kim, J.-Y., Park, K.-W., Koo, B.-K., Oh, B.-H., Park, Y.-B., Chaqour, B., Walsh, K., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000257945.97958.77 · Cited by 107 · see citing works

Mechanisms of Hypoxic Gene Regulation of Angiogenesis Factor Cyr61 in Melanoma Cells

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An essential role for stromal interaction molecule 1 in neointima formation following arterial injury

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Induction of C/EBPα activity alters gene expression and differentiation of human CD34+ cells

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Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways

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Id1 Restrains p21 Expression to Control Endothelial Progenitor Cell Formation

Ciarrocchi, A., Janković, V., Shaked, Y., Nolan, D. J., Mittal, V., Kerbel, R. S., Nimer, S. D., & Benezra, R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001338 · Cited by 75 · see citing works

CCN5 Is a Growth Arrest-Specific Gene That Regulates Smooth Muscle Cell Proliferation and Motility

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Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression

Seeger, F. H., Sedding, D., Langheinrich, A. C., Haendeler, J., Zeiher, A. M., & Dimmeler, S. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0072-9 · Cited by 69 · see citing works

Nov Gene Encodes Adhesion Factor for Vascular Smooth Muscle Cells and Is Dynamically Regulated in Response to Vascular Injury

Ellis, P. D., Chen, Q., Barker, P. J., Metcalfe, J. C., & Kemp, P. R. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1912 · Cited by 66 · see citing works

CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model

Matsumae, H., Yoshida, Y., Ono, K., Togi, K., Inoue, K., Furukawa, Y., Nakashima, Y., Kojima, Y., Nobuyoshi, M., Kita, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.162362 · Cited by 59 · see citing works

AMD3100 Mobilizes Endothelial Progenitor Cells in Mice, But Inhibits Its Biological Functions by Blocking an Autocrine/Paracrine Regulatory Loop of Stromal Cell Derived Factor-1 In Vitro

Yin, Y., Huang, L. J., Zhao, X., Fang, Y., Yu, S., Zhao, J., & Cui, B. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3180587e4d · Cited by 52 · see citing works

Stretch-inducible Expression of the Angiogenic Factor CCN1 in Vascular Smooth Muscle Cells Is Mediated by Egr-1

Grote, K., Bavendiek, U., Grothusen, C., Flach, I., Hilfiker-Kleiner, D., Drexler, H., & Schieffer, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406532200 · Cited by 52 · see citing works

COP‐1, a member of the CCN family, is a heparin‐induced growth arrest specific gene in vascular smooth muscle cells

Delmolino, L. M., Stearns, N. A., & Castellot, J. J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1100 · Cited by 47 · see citing works

Differentiation of circulating endothelial progenitor cells to a cardiomyogenic phenotype depends on E‐cadherin

Koyanagi, M., Urbich, C., Chavakis, E., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.071 · Cited by 45 · see citing works

The matrix protein CCN1 (CYR61) promotes proliferation, migration and tube formation of endothelial progenitor cells

YU, Y., GAO, Y., WANG, H., Huang, L. J., Qin, J., Guo, R., SONG, M., YU, S., CHEN, J., & CUI, B. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.08.001 · Cited by 37 · see citing works

Proteolysis of CCN1 by Plasmin: Functional Implications

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CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells

Schütze, N., Schenk, R., Fiedler, J., Mattes, T., Jakob, F. J., & Brenner, R. E. (2007) · BMC Cell Biology · doi:10.1186/1471-2121-8-45 · Cited by 35 · see citing works

Bone marrow-derived cells are not involved in reendothelialized endothelium as endothelial cells after simple endothelial denudation in mice

Tsuzuki, M. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0021-7 · Cited by 33 · see citing works

Impaired interaction of platelets with endothelial progenitor cells in patients with cardiovascular risk factors

Dernbach, E., Randriamboavonjy, V., Fleming, I., et al. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0734-z · Cited by 31 · see citing works

Role of extracellular signal-regulated kinase for endothelial progenitor cell dysfunction in coronary artery disease

Friedrich, E. B., Werner, C. M., Walenta, K. L. H., Böhm, M., & Scheller, B. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0022-6 · Cited by 25 · see citing works

The Angiogenic Factor Cysteine-Rich 61 (CYR61, CCN1) Supports Vascular Smooth Muscle Cell Adhesion and Stimulates Chemotaxis through Integrin  6 1 and Cell Surface Heparan Sulfate Proteoglycans

Grzeszkiewicz, T. M. (2002) · Endocrinology · doi:10.1210/en.143.4.1441 · Cited by 23 · see citing works

Integrin–Mediated Control of Cell Growth

Schuppan, D., & Ocker, M. (2003) · Hepatology · doi:10.1053/jhep.2003.50338 · Cited by 22 · see citing works

Inhibitor of DNA binding-1 promotes the migration and proliferation of endothelial progenitor cells in vitro

Wang, H., Yu, Y., Guo, R., et al. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0236-9 · Cited by 20 · see citing works

Up-Regulation of cyr61 in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats

Unoki‐Kubota, H., Furukawa, K., Yonekura, H., Ueda, Y., Katsuda, S., Mori, M., Nakagawara, K.-I., Mabuchi, H., & Yamamoto, H. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000079329.07787.7f · Cited by 10 · see citing works

CCN1/CYR61: the very model of a modern matricellular protein

Lau, L. F. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0778-3 · Cited by 338 · see citing works

The matricellular “cysteine‐rich protein 61” is released from activated platelets and increased in the circulation during experimentally induced sepsis

Hviid, C. V. B., Samulin Erdem, J., Drechsler, S., Weixelbaumer, K., Ahmed, M. S., Attramadal, H., Redl, H., Bahrami, S., Osuchowski, M. F., & Aasen, A. O. (2014) · Shock · doi:10.1097/shk.0000000000000105 · Cited by 15 · see citing works

Restenosis drug discovery--a formidable task.

Meng, C. Q. (2001) · PubMed · Cited by 2 · see citing works

The Matricellular Protein Cysteine-Rich Protein 61 (Cyr61/CCN1) Prevents Blood Vessel Loss and Induces Blood Vessel Regrowth in a Mouse Model of Oxygen-Induced Retinopathy

Shrier, E. M., Grant, M. B., Lee, H.-S., et al. (2010) · Investigative Ophthalmology & Visual Science

The expression of connexin in rabbit iliac artery restenosis models

Cao, L. (2014) · Journal of Clinical Cardiology

Matricellular Protein Cysteine-Rich Angiogenic Inducer 61 (CCN1/CYR61) Attenuates Fibrogenic Response In Trabecular Meshwork Cells

Gupta, I., & Pattabiraman, P. P. (2017) · Investigative Ophthalmology & Visual Science

Tissue characteristics of neointima in late restenosis: integrated backscatter intravascular ultrasound analysis for in-stent restenosis

Ando, H., Suzuki, A., Sakurai, S., et al. (2016) · Heart and Vessels · doi:10.1007/s00380-016-0903-1 · Cited by 12 · see citing works