Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis
Open accessAbstract
Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)–derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.
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BMDCs promote metastasis by producing chemokines that recruit tumor cells to the lung by mechanisms that include stimulation of tumor cell extravasation.
“The BMDCs promote metastasis by producing chemokines that recruit tumor cells to the lung by mechanisms that include stimulation of tumor cell extravasation”
From Hypoxic control of metastasis (2016) · cites this paper as [95]
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- Authors
- Gao, D., Nolan, D. J., Mellick, A. S., Bambino, K., McDonnell, K., & Mittal, V.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Houston Methodist (US)
- Corresponding author
- Mittal, Vivek
- Venue
- Science
- Published
- 2008-01-11
- Volume
- 319
- Issue
- 5860
- Pages
- 195-198
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963655153
- Cited by
- 632
- References
- 20
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 18 · 2022: 14 · 2021: 18 · 2020: 21 · 2019: 20 · 2018: 15 · 2017: 33 · 2016: 32 · 2015: 34 · 2014: 44 · 2013: 60 · 2012: 70
- FWCI
- 33.15
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- Griffith Research Online (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- endothelial progenitor cells, lung metastasis, angiogenic switch, bone marrow-derived cells, EPC mobilization, tumor angiogenesis, metastatic colonization
- MeSH terms
- Animals, Bone Marrow Cells, Female, Lung Neoplasms, Male, Mice, Inbred C57BL, Mice, Transgenic, Neoplasm Metastasis, Neoplasm Transplantation, Neovascularization, Pathologic, Stem Cells, Mammary Neoplasms, Animal, Gene Expression, Disease Progression, Carcinoma, Lewis Lung, Endothelial Cells, Mice, Inhibitor of Differentiation Protein 1
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