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Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections
Open accessAbstract
Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and other neurodegenerative tauopathies. An increasing number of studies implicate the cell-to-cell propagation of tau pathology in the progression of tauopathies. We recently showed (Iba et al., J Neurosci 33:1024-1037, 2013) that inoculation of preformed synthetic tau fibrils (tau PFFs) into the hippocampus of young transgenic (Tg) mice (PS19) overexpressing human P301S mutant tau induced robust tau pathology in anatomically connected brain regions including the locus coeruleus (LC). Since Braak and colleagues hypothesized that the LC is the first brain structure to develop tau lesions and since LC has widespread connections throughout the CNS, LC neurons could be the critical initiators of the stereotypical spreading of tau pathology through connectome-dependent transmission of pathological tau in AD. Here, we report that injections of tau PFFs into the LC of PS19 mice induced propagation of tau pathology to major afferents and efferents of the LC. Notably, tau pathology propagated along LC efferent projections was localized not only to axon terminals but also to neuronal perikarya, suggesting transneuronal transfer of templated tau pathology to neurons receiving LC projections. Further, brainstem neurons giving rise to major LC afferents also developed perikaryal tau pathology. Surprisingly, while tangle-bearing neurons degenerated in the LC ipsilateral to the injection site starting 6 months post-injection, no neuron loss was seen in the contralateral LC wherein tangle-bearing neurons gradually cleared tau pathology by 6-12 months post-injection. However, the spreading pattern of tau pathology observed in our LC-injected mice is different from that in AD brains since hippocampus and entorhinal cortex, which are affected in early stages of AD, were largely spared of tau inclusions in our model. Thus, while our study tested critical aspects of the Braak hypothesis of tau pathology spread, this novel mouse model provides unique opportunities to elucidate mechanisms underlying the selective vulnerability of neurons to acquire tau pathology and succumb to or resist tau-mediated neurodegeneration.
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“As mice have primarily monocular vision, with >95% of RGCs projecting into the contralateral side of the brain, the unaffected side of the visual system can serve as an internal control 26, 27”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [27]
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Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480
Self-citationSynapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208
Self-citationStages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318232a379 · Cited by 2,194
Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174
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Bondi, M. W., Edmonds, E. C., & Salmon, D. P. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771700100x · Cited by 649
The road to restoring neural circuits for the treatment of Alzheimer's disease
Canter, R. G., Penney, J., & Tsai, L.-H. (2016) · Nature · doi:10.1038/nature20412 · Cited by 565
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Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540
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Chen, Y., & Yu, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02853-3 · Cited by 516
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Jucker, M., & Walker, L. C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0238-6 · Cited by 450
Guo, J. L., Narasimhan, S., Changolkar, L., He, Z., Stieber, A., Zhang, B., Gathagan, R. J., Iba, M., McBride, J. D., Trojanowski, J. Q., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160833 · Cited by 440
Self-citationMAPT mutations, tauopathy, and mechanisms of neurodegeneration
Strang, K. H., Golde, T. E., & Giasson, B. I. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0197-x · Cited by 424
Theofilas, P., Ehrenberg, A. J., Dunlop, S., Di Lorenzo Alho, A. T., Nguy, A., Leite, R. E. P., Rodriguez, R. D., Mejia, M. B., Suemoto, C. K., Ferretti-Rebustini, R. E. D. L., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.06.2362 · Cited by 416
What is the evidence that tau pathology spreads through prion-like propagation?
Mudher, A., Colin, M., Dujardin, S., Medina, M., Dewachter, I., Alavi Naini, S. M., Mandelkow, E.-M., Mandelkow, E., Buée, L., Goedert, M., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0488-7 · Cited by 384
Narasimhan, S., Guo, J. L., Changolkar, L., Stieber, A., McBride, J. D., Silva, L. V., He, Z., Zhang, B., Gathagan, R. J., Trojanowski, J. Q., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1230-17.2017 · Cited by 374
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Weinshenker, D. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.01.010 · Cited by 339
Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration
Goedert, M., Masuda-Suzukake, M., & Falcon, B. (2017) · Brain · doi:10.1093/brain/aww230 · Cited by 323
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Katsinelos, T., Zeitler, M., Dimou, E., Karakatsani, A., Müller, H., Nachman, E., Steringer, J. P., de Almodóvar, C. R., Nickel, W., & Jahn, T. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.056 · Cited by 274
Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo
Bolós, M., Llorens-Martín, M., Jurado-Arjona, J., Hernández, F., Rábano, A., & Avila, J. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150704 · Cited by 234
Jacobs, H. I. L., Becker, J. A., Kwong, K. K., Engels, N., Prokopiou, P. C., Papp, K. V., Properzi, M. J., Hampton, O. L., Uquillas, F. D., Sanchez, J. S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj2511 · Cited by 236
Fontaine, S. N., Zheng, D., Sabbagh, J. J., Martin, M. D., Chaput, D., Darling, A. L., Trotter, J. H., Stothert, A. R., Nordhues, B. A., Lussier, A. L., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593489 · Cited by 214
Noradrenergic Modulation of Cognition in Health and Disease
Borodovitsyna, O., Flamini, M. D., & Chandler, D. J. (2017) · Neural Plasticity · doi:10.1155/2017/6031478 · Cited by 227
Traumatic Brain Injury Induces Tau Aggregation and Spreading
Edwards, G., Zhao, J., Dash, P. K., Soto, C., & Moreno-Gonzalez, I. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2018.6348 · Cited by 195
The Cholinergic System, the Adrenergic System and the Neuropathology of Alzheimer’s Disease
Bekdash, R. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031273 · Cited by 222
Woerman, A. L., Aoyagi, A., Patel, S. S., Kazmi, S. A., Lobach, I. V., Grinberg, L. T., McKee, A. C., Seeley, W. W., Olson, S. H., & Prusiner, S. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616344113 · Cited by 180
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease
Franzmeier, N., Dewenter, A., Frontzkowski, L. K., Dichgans, M., Rubinski, A., Neitzel, J., Smith, R. A., Strandberg, O. T., Ossenkoppele, R., Büerger, K., et al. (2020) · Science Advances · doi:10.1126/sciadv.abd1327 · Cited by 178
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
Ait‐Bouziad, N., Lv, G., Mahul‐Mellier, A., Xiao, S., Zorludemir, G., Eliezer, D., Walz, T., & Lashuel, H. A. (2017) · Nature Communications · doi:10.1038/s41467-017-01575-4 · Cited by 149
Experimental evidence for the age dependence of tau protein spread in the brain
Wegmann, S., Bennett, R. E., Delorme, L., Robbins, A. B., Hu, M., MacKenzie, D., Kirk, M. J., Schiantarelli, J., Tunio, N., Amaral, A. C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw6404 · Cited by 144
Niu, L., Zhang, F., Xu, X., Yang, Y., Li, S., Liu, H., & Le, W. (2021) · Brain Pathology · doi:10.1111/bpa.13028 · Cited by 151
Mechanisms of protein toxicity in neurodegenerative diseases
Chung, C. G., Lee, H., & Lee, S. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2854-4 · Cited by 142
Strang, K. H., Croft, C. L., Sorrentino, Z. A., Chakrabarty, P., Golde, T. E., & Giasson, B. I. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.815357 · Cited by 124
Chen, C., Zhou, Y., Wang, H., Alam, A. M., Kang, S. S., Ahn, E. H., Liu, X., Jia, J., & Ye, K. (2021) · The EMBO Journal · doi:10.15252/embj.2020106320 · Cited by 138
Induction of a transmissible tau pathology by traumatic brain injury
Zanier, E. R., Bertani, I., Sammali, E., Pischiutta, F., Chiaravalloti, M. A., Vegliante, G., Masone, A., Corbelli, A., Smith, D. H., Menon, D. K., et al. (2018) · Brain · doi:10.1093/brain/awy193 · Cited by 136
Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain
Aoyagi, A., Condello, C., Stöhr, J., Yue, W., Rivera, B. M., Lee, J. C., Woerman, A. L., Halliday, G. M., van Duinen, S. G., Ingelsson, M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat8462 · Cited by 132
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Wegmann, S., Maury, E. A., Kirk, M. J., Saqran, L., Roe, A., DeVos, S. L., Nicholls, S., Fan, Z., Takeda, S., Cagsal‐Getkin, O., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201592748 · Cited by 132
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. N., & Kayed, R. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01012-6 · Cited by 130
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Vasili, E., Dominguez‐Meijide, A., & Outeiro, T. F. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00107 · Cited by 121
Therapeutic strategies for the treatment of tauopathies: Hopes and challenges
Khanna, M. R., Kovalevich, J., Lee, V. M. ‐., Trojanowski, J. Q., & Brunden, K. R. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.006 · Cited by 116
Self-citationA Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy
Trzeciakiewicz, H., Tseng, J., Wander, C. M., Madden, V. J., Tripathy, A., Yuan, C., & Cohen, T. J. (2017) · Scientific Reports · doi:10.1038/srep44102 · Cited by 112
Different tau species lead to heterogeneous tau pathology propagation and misfolding
Dujardin, S., Bégard, S., Caillierez, R., Lachaud, C., Carrier, S., Lieger, S., Gonzalez, J. A., Deramecourt, V., Déglon, N., Maurage, C.-A., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0637-7 · Cited by 109
Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy
DeLeo, A. M., & Ikezu, T. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9768-z · Cited by 109
Ondrejčák, T., Klyubin, I. V., Corbett, G. T., Fraser, G. M., Hong, W., Mably, A. J., Gardener, M. J., Hammersley, J., Perkinton, M. S., Billinton, A., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1700-18.2018 · Cited by 110
TIA1 regulates the generation and response to toxic tau oligomers
Jiang, L., Ash, P. E. A., Maziuk, B. F., Ballance, H. I., Boudeau, S., Abdullatif, A. A., Orlando, M., Petrucelli, L., Ikezu, T., & Wolozin, B. L. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1937-5 · Cited by 100
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice
Zhu, Y., Zhan, G., Fenik, P., Brandes, M., Bell, P., François, N., Shulman, K., & Veasey, S. C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0275-18.2018 · Cited by 110
Baker, S., Polanco, J. C., & Götz, J. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160371 · Cited by 98
Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies
Vogels, T., Leuzy, A., Cicognola, C., Ashton, N. J., Smolek, T., Novák, M., Blennow, K., Zetterberg, H., Hromádka, T., Žilka, N., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.019 · Cited by 99
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
Wang, P., & Ye, Y. (2021) · Nature Communications · doi:10.1038/s41467-020-20322-w · Cited by 93
Prions and Protein Assemblies that Convey Biological Information in Health and Disease
Sanders, D. W., Kaufman, S. K., Holmes, B. B., & Diamond, M. I. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.026 · Cited by 92
Thal, D. R., & Tomé, S. O. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.10.006 · Cited by 92
Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins
Zhou, Q., Lehmer, C., Michaelsen, M., Mori, K., Alterauge, D., Baumjohann, D., Schludi, M. H., Greiling, J., Farny, D., Flatley, A., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607054 · Cited by 89
Tau prion-like propagation: state of the art and current challenges
Dujardin, S., & Hyman, B. T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9358-8_23 · Cited by 84
Wu, X., Piña-Crespo, J., Zhang, Y., Chen, X., & Xu, H. (2017) · Chinese Medical Journal · doi:10.4103/0366-6999.220313 · Cited by 82
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system
Lopes, D. M., Llewellyn, S. K., & Harrison, I. F. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00293-2 · Cited by 75
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Stancu, I. C., Lodder, C., Botella Lucena, P., Vanherle, S., Gutiérrez de Ravé, M., Terwel, D., Bottelbergs, A., & Dewachter, I. (2022) · Glia · doi:10.1002/glia.24160 · Cited by 72
Models of Network Spread and Network Degeneration in Brain Disorders
Raj, A., & Powell, F. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.07.012 · Cited by 67
Scialò, C., Cecco, E. D., Manganotti, P., & Legname, G. (2019) · Viruses · doi:10.3390/v11030261 · Cited by 69
Ghosh, A., Torraville, S. E., Mukherjee, B., Walling, S. G., Martin, G. M., Harley, C. W., & Yuan, Q. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0511-2 · Cited by 74
Satoh, A., & Iijima, K. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.027 · Cited by 72
Henrich, M. T., Geibl, F. F., Lee, B., Chiu, W., Koprich, J. B., Brotchie, J. M., Timmermann, L., Decher, N., Matschke, L. A., & Oertel, W. H. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0541-1 · Cited by 70
Prion-like mechanisms in Alzheimer disease
Walker, L. C. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63945-5.00016-7 · Cited by 67
Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease
Olivieri, P., Lagarde, J., Lehéricy, S., Valabrègue, R., Michel, A., Mace, P., Caillé, F., Gervais, P., Bottlaender, M., & Sarazin, M. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50818 · Cited by 71
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders
Hasegawa, M., Nonaka, T., & Masuda‐Suzukake, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.11.010 · Cited by 71
Dunn, M., Henke, A., Clark, S. D., Kovalyova, Y., Kempadoo, K. A., Karpowicz, R. J., Kandel, E. R., Sulzer, D., & Sameš, D. (2018) · Nature Communications · doi:10.1038/s41467-018-05075-x · Cited by 65
Giorgi, F. S., Galgani, A., Puglisi‐Allegra, S., Limanaqi, F., Busceti, C. L., & Fornai, F. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24718 · Cited by 69
Tau misfolding efficiently propagates between individual intact hippocampal neurons
Hallinan, G. I., Vargas-Caballero, M., West, J., & Deinhardt, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1590-19.2019 · Cited by 59
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Oakley, S. S., Maina, M. B., Marshall, K. E., Al‐Hilaly, Y. K., Harrington, C., Wischik, C. M., & Serpell, L. C. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.590754 · Cited by 59
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Giorgi, F. S., Ryskalin, L., Ruffoli, R., Biagioni, F., Limanaqi, F., Ferrucci, M., Busceti, C. L., Bonuccelli, U., & Fornai, F. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00080 · Cited by 63
Microglia: Friend and foe in tauopathy
Odfalk, K. F., Bieniek, K. F., & Hopp, S. C. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102306 · Cited by 60
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Chalermpalanupap, T., Weinshenker, D., & Rorabaugh, J. M. (2017) · Neural Plasticity · doi:10.1155/2017/7829507 · Cited by 59
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Giorgi, F. S., Biagioni, F., Galgani, A., Pavese, N., Lazzeri, G., & Fornai, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228630 · Cited by 63
Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease
Ameen‐Ali, K. E., Wharton, S. B., Simpson, J. E., Heath, P. R., Sharp, P. S., & Berwick, J. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12440 · Cited by 59
The AD tau core spontaneously self-assembles and recruits full-length tau to filaments
Carlomagno, Y., Manne, S., Deture, M. A., Prudencio, M., Zhang, Y., Al‐Shaikh, R. H., Dunmore, J. A., Daughrity, L. M., Song, Y., Castanedes‐Casey, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108843 · Cited by 59
The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype
Pletniková, O., Kageyama, Y., Rudow, G. L., LaClair, K. D., Albert, M., Crain, B. J., Tian, J., Fowler, D. R., & Troncoso, J. C. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.07.007 · Cited by 57
Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies
Wang, J., Jin, W., Bu, X., Zeng, F., Huang, Z., Li, W., Shen, L., Zhuang, Z., Fang, Y., Sun, B., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1891-2 · Cited by 62
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Bueichekú, E., Diez, I. P., Kim, C. M., Becker, J. A., Koops, E. A., Kwong, K. K., Papp, K. V., Salat, D. H., Bennett, D. A., Rentz, D. M., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00626-y · Cited by 70
Clustering of Tau fibrils impairs the synaptic composition of α3‐Na+/K+‐ATPase and AMPA receptors
Shrivastava, A. N., Redeker, V., Pieri, L., Bousset, L., Renner, M. L., Madiona, K., Mailhes‐Hamon, C., Coens, A., Buée, L., Hantraye, P., et al. (2019) · The EMBO Journal · doi:10.15252/embj.201899871 · Cited by 62
Yu, A., Fox, S. G., Cavallini, A., Kerridge, C., O’Neill, M. J., Wolak, J., Bose, S., & Morimoto, R. I. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007527 · Cited by 55
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Leanza, G., Gulino, R., & Zorec, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00254 · Cited by 54
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Giorgi, F. S., Saccaro, L. F., Galgani, A., Busceti, C. L., Biagioni, F., Frati, A., & Fornai, F. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.08.007 · Cited by 53
Cecco, E. D., Celauro, L., Vanni, S., Grandolfo, M., Bistaffa, E., Moda, F., Aguzzi, A., & Legname, G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15040 · Cited by 55
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Metadata
- Authors
- Iba, M., McBride, J. D., Guo, J. L., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- Corresponding author
- Lee, Virginia M.-Y.
- Venue
- Acta Neuropathologica
- Published
- 2015-07-07
- Volume
- 130
- Issue
- 3
- Pages
- 349-362
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4545685
- OpenAlex
- W812488793
- Cited by
- 223
- References
- 46
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 17 · 2023: 15 · 2022: 20 · 2021: 22 · 2020: 32 · 2019: 26 · 2018: 23 · 2017: 24 · 2016: 16 · 2015: 2
- FWCI
- 15.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health Grant (AG17586)
- the Marian S. Ware Alzheimer Program Cure Alzheimer’s Fund
- the Karen Cohen Segal and Christopher S. Segal Alzheimer Drug Discovery Initiative Fund
- the Paula C. Schmerler Fund for Alzheimer’s Research
- the Barrist Neurodegenerative Disease Research Fund
- the Eleanor Margaret Kurtz Endowed Fund
- the Mary Rasmus Endowed Fund for Alzheimer’s Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- cell-to-cell transmission, locus coeruleus, PS19 mice, P301S tau, Alzheimer's disease, Braak hypothesis, tau tangles, efferent projections, axon terminals, neuronal perikarya, neurodegeneration
- MeSH terms
- Afferent Pathways, Animals, Disease Models, Animal, Efferent Pathways, Escherichia coli, Female, Humans, Hypothalamus, Immunohistochemistry, Locus Coeruleus, Male, Mice, Transgenic, Mutation, Neurons, Thalamus, Tyrosine 3-Monooxygenase, tau Proteins, Disease Progression, Tauopathies
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