Seizures are a druggable mechanistic link between TBI and subsequent tauopathy.
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Abstract
Traumatic brain injury (TBI) is a prominent risk factor for dementias including tauopathies like chronic traumatic encephalopathy (CTE). The mechanisms that promote prion-like spreading of Tau aggregates after TBI are not fully understood, in part due to lack of tractable animal models. Here, we test the putative role of seizures in promoting the spread of tauopathy. We introduce ‘tauopathy reporter’ zebrafish expressing a genetically encoded fluorescent Tau biosensor that reliably reports accumulation of human Tau species when seeded via intraventricular brain injections. Subjecting zebrafish larvae to a novel TBI paradigm produced various TBI features including cell death, post–traumatic seizures, and Tau inclusions. Bath application of dynamin inhibitors or anticonvulsant drugs rescued TBI-induced tauopathy and cell death. These data suggest a role for seizure activity in the prion-like seeding and spreading of tauopathy following TBI. Further work is warranted regarding anti-convulsants that dampen post-traumatic seizures as a route to moderating subsequent tauopathy.
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Tau aggregation following traumatic brain injury administration was prevented by the anti-convulsant ezogabine and exacerbated by kainate treatment, demonstrating a role of seizure activity in mediating tauopathy development.
“Furthermore, tau aggregation following TBI administration was prevented by the anti-convulsant ezogabine and exacerbated by kainate treatment, demonstrating a role of seizure activity in mediating tauopathy development (Alyenbaawi et al., 2021).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Alyenbaawi et al., 2021
In Results, “Post-traumatic seizure intensity influences tauopathy progression” (page unavailable), the paper reports that retigabine significantly reduced tau aggregates after TBI, with many—but not all—treated zebrafish larvae developing no aggregates. Kainate increased tauopathy fourfold, and the authors attribute the drugs’ opposing effects largely to their modulation of post-traumatic seizures. The claim overstates the retigabine finding as complete prevention; our copy also calls the drug retigabine, not ezogabine. (LLM, conf=0.87)
Experimental — accuracy not yet measuredAnimal models reveal increased p-tau levels in the brain associated with traumatic brain injury-induced epileptic activity.
“and animal models reveal increased p-tau levels in the brain associated with TBI-induced epileptic activity (Cho et al., 2020; Alyenbaawi et al., 2021).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Alyenbaawi et al., 2021
The Results (‘Post-traumatic seizure intensity influences tauopathy progression’; page unavailable) report more tau aggregates in TBI-treated zebrafish larvae that displayed seizure-like behavior, supporting the association. But this paper measures Tau aggregates, not increased phosphorylated tau (p-tau) levels; its Discussion mentions p-tau expression only when describing a separate epilepsy study. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTau aggregation positively correlated with traumatic brain injury severity and the presence of seizure-like clonic shaking in a transgenic zebrafish model.
“Tau aggregation positively correlated with TBI severity and the presence of seizure-like clonic shaking.”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Alyenbaawi et al., 2021
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Maheras, A., Dix, B., Carmo, O. M. S., Young, A., Gill, V. N., Sun, J. L., Booker, A. R., Thomason, H. A., Ibrahim, A. E., Stanislaw, L., et al. (2018) · eNeuro · doi:10.1523/eneuro.0208-17.2017 · Cited by 41 · see citing works
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Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors
McGeachie, A. B., Odell, L. R., Quan, A., Daniel, J. A., Chau, N., Hill, T. A., Gorgani, N. N., Keating, D. J., Cousin, M. A., van Dam, E. M., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb400137p · Cited by 34 · see citing works
Reduced neuronal proliferation by proconvulsant drugs in the developing zebrafish brain
Kim, Y., Lee, Y., Lee, K., Lee, T., Kim, Y.-J., & Lee, C. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.04.054 · Cited by 31 · see citing works
BIR, C. A., VandeVord, P. J., Shen, Y., Raza, W., & Haacke, E. M. (2012) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2011.12.003 · Cited by 31 · see citing works
Ping, X., & Jin, X. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.3913 · Cited by 30 · see citing works
Transcellular Spreading of Tau in Tauopathies
Demaegd, K. C., Schymkowitz, J. W. H., & Rousseau, F. (2018) · ChemBioChem · doi:10.1002/cbic.201800288 · Cited by 30 · see citing works
Zebrafish model of posttraumatic epilepsy.
Cho, S., Park, E., Telliyan, T., Baker, A., & Reid, A. Y. (2020) · Epilepsia · doi:10.1111/epi.16589 · Cited by 29 · see citing works
Functional and behavioral signatures of Kv7 activator drug subtypes
Kanyo, R., Wang, C. K., Locskai, L. F., Li, J., Allison, W. T., & Kurata, H. T. (2020) · Epilepsia · doi:10.1111/epi.16592 · Cited by 27 · see citing works
Self-citationKasatkina, L. A. (2016) · Scientific Reports · doi:10.1038/srep34749 · Cited by 27 · see citing works
Menezes, F. P., Rico, E. P., & da Silva, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.04.004 · Cited by 26 · see citing works
Leighton, P. L. A., Kanyo, R., Neil, G. J., Pollock, N. M., & Allison, W. T. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001171 · Cited by 25 · see citing works
Self-citationDuVal, M. G., Oel, A. P., & Allison, W. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092991 · Cited by 23 · see citing works
Self-citationEskandari-Sedighi, G., Daude, N., Gapeshina, H., Sanders, D. W., Kamali-Jamil, R., Yang, J., Shi, B., Wille, H., Ghetti, B., Diamond, M. I., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0215-7 · Cited by 22 · see citing works
Self-citationMcCutcheon, V., Park, E., Liu, E., Wang, Y., Wen, X., & Baker, A. J. (2016) · Zebrafish · doi:10.1089/zeb.2015.1188 · Cited by 17 · see citing works
Kanyo, R., Leighton, P. L. A., Neil, G. J., Locskai, L. F., & Allison, W. T. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113283 · Cited by 14 · see citing works
Self-citationHanwell, D., Hutchinson, S. A., Collymore, C., Bruce, A. E. E., Louis, R., Ghalami, A., Allison, W. T., Ekker, M., Eames, B. F., Childs, S. J., et al. (2016) · Zebrafish · doi:10.1089/zeb.2016.1286 · Cited by 14 · see citing works
Self-citationZebrafish Brain Ventricle Injection
Gutzman, J. H., & Sive, H. L. (2009) · Journal of Visualized Experiments · doi:10.3791/1218-v · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging
van Vliet, E. A., & Marchi, N. (2022) · Epilepsia · doi:10.1111/epi.17210 · Cited by 68 · see citing works
Modeling neurodegenerative disorders in zebrafish
Bashirzade, A. A., Zabegalov, K. N., Volgin, A. D., Belova, A. S., Demin, K. A., de Abreu, M. S., Babchenko, V. Y., Bashirzade, K. A., Yenkoyan, K. B., Tikhonova, M. A., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104679 · Cited by 67 · see citing works
d’Amora, M., Galgani, A., Marchese, M., Tantussi, F., Faraguna, U., Angelis, F. D., & Giorgi, F. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097702 · Cited by 57 · see citing works
Hickman, L. B., Stern, J. M., Silverman, D. H. S., Salamon, N., & Vossel, K. A. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1241638 · Cited by 36 · see citing works
Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
Hwang, K., Vaknalli, R. N., Addo-Osafo, K., Vicente, M., & Vossel, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903973 · Cited by 35 · see citing works
“Rapamycin treatment inhibits both tau hyperphosphorylation (Liu et al., 2013; Ozcelik et al., 2013; Tramutola et al., 2017) and the development of status epilepticus and chronic epilepsy in models of pharmacological seizure induction (Zeng et al., 2008; Huang et al., 2010), TLE (Drion et al., 2016), and PTE (Guo et al…”
BackgroundInfluentialLongitudinal in vivo imaging of adult Danionella cerebrum using standard confocal microscopy
Lam, P. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049753 · Cited by 26 · see citing works
Giong, H.-K., Subramanian, M., Yu, K., & Lee, J.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168465 · Cited by 29 · see citing works
Navarrete, C. M., García‐Martín, A., Correa-Sáez, A., Prados, M. E., Fernández, F., Pineda, R., Mazzone, M., Benito, M. Á., Calzado, M. A., & Muñóz, E. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02540-9 · Cited by 29 · see citing works
Hentig, J., Cloghessy, K., Lahne, M., Jung, Y. J., Petersen, R. A., Morris, A. C., & Hyde, D. R. (2021) · Biomedicines · doi:10.3390/biomedicines9080861 · Cited by 26 · see citing works
Kanyo, R., Amin, M. R., Locskai, L. F., Bouvier, D. D., Olthuis, A. M., Allison, W. T., & Ali, D. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-90902-3 · Cited by 22 · see citing works
Self-citationNg, B., Rowland, H. A., Wei, T., Arunasalam, K., Hayes, E. M., Koychev, I., Hedegaard, A., Ribe, E. M., Chan, D., Chessell, T., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac267 · Cited by 18 · see citing works
Vigil, F. A., Belchior, H., Bugay, V., Bazaldua, I. I., Stoja, A. P., Dantas, D. C., Chun, S. H., Farmer, A., Bozdemir, E., Holstein, D. M., et al. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01361-9 · Cited by 20 · see citing works
Alyenbaawi, H., Allison, W. T., & Mok, S. (2020) · Biomolecules · doi:10.3390/biom10111487 · Cited by 18 · see citing works
Self-citationSite and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels
Kanyo, R., Lamothe, S. M., Urrutia, A., Goodchild, S. J., Allison, W. T., Dean, R. A., & Kurata, H. T. (2023) · Function · doi:10.1093/function/zqad021 · Cited by 14 · see citing works
Self-citationAntiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury
Locskai, L. F., Alyenbaawi, H., & Allison, W. T. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-013930 · Cited by 11 · see citing works
Self-citationHentig, J., Campbell, L. J., Cloghessy, K., Lee, M., Boggess, B., & Hyde, D. R. (2021) · Biomedicines · doi:10.3390/biomedicines10010032 · Cited by 10 · see citing works
Delivering Traumatic Brain Injury to Larval Zebrafish
Gill, T., Locskai, L. F., Burton, A. H., Alyenbaawi, H., Wheeler, T., Burton, E. A., & Allison, W. T. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3401-1_1 · Cited by 8 · see citing works
Self-citationBurton, A. H., Jiao, B., Bai, Q., Laar, V. S. V., Wheeler, T. B., Watkins, S. C., Bruchez, M. P., & Burton, E. A. (2023) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2023.110001 · Cited by 8 · see citing works
Self-citationAbusive Head Trauma Animal Models: Focus on Biomarkers
Nikam, R. M., Kecskemethy, H. H., Kandula, V. V. R., Averill, L. W., Langhans, S. A., & Yue, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054463 · Cited by 8 · see citing works
A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
Hentig, J., Cloghessy, K., Dunseath, C., & Hyde, D. R. (2021) · Journal of Visualized Experiments · doi:10.3791/62709 · Cited by 8 · see citing works
Modeling traumatic brain and neural injuries: insights from zebrafish
Murashova, L. A., & Dyachuk, V. A. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1552885 · Cited by 7 · see citing works
Research Progress on the Immune-Inflammatory Mechanisms of Posttraumatic Epilepsy
Dang, Y., & Wang, T. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01429-2 · Cited by 7 · see citing works
Recent insights from non-mammalian models of brain injuries: an emerging literature
Katchur, N. J., & Notterman, D. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1378620 · Cited by 6 · see citing works
Lazarev, V. F., Alhasan, B. A., Guzhova, I. V., & Margulis, B. A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1593122 · Cited by 4 · see citing works
Locskai, L. F., Gill, T., Tan, S. A. W., Burton, A. H., Alyenbaawi, H., Burton, E. A., & Allison, W. T. (2025) · Biology Open · doi:10.1242/bio.060601 · Cited by 5 · see citing works
Self-citationMrzyglod, A., Mebrouk, A., Bartkiewicz, J., Hachami, H. E., Ryniejska, M., de Tisi, J., Coras, R., Blümcke, I., Xiao, F., Miserocchi, A., et al. (2025) · Epilepsia · doi:10.1111/epi.18418 · Cited by 3 · see citing works
Tau pathology in epilepsy: emerging mechanisms and translational opportunities
Sen, A., Tai, X. Y., Galanopoulou, A. S., Thom, M., Aronica, E., Vivash, L. E., Hardmeier, M., Amos, A., Rüegg, S. J., Koepp, M. J., et al. (2026) · Brain · doi:10.1093/brain/awag108 · Cited by 2 · see citing works
Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury
O’Donnell, J. C., Swanson, R. L., Wofford, K. L., Grovola, M. R., Purvis, E. M., Petrov, D., & Cullen, D. K. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-95884-8_13 · Cited by 2 · see citing works
Locskai, L. F., Gill, T., Tan, S. A. W., Burton, A. H., Alyenbaawi, H., Burton, E. A., & Allison, W. T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.14.599067 · Cited by 2 · see citing works
Self-citationYue, J., Carriquiriborde, V., Cheng, W. H., Yildirim, T., Fan, J., Tok, S., Kelly, M., Wellington, C. L., & Kent, B. A. (2026) · Journal of Neurotrauma · doi:10.1177/08977151261430301 · Cited by 2 · see citing works
High-Precision Pneumatic Induction of Traumatic Brain Injury in Larval Zebrafish
Wang, K., Zhang, P., & Geng, Y.-J. (2026) · Zebrafish · doi:10.1177/15458547261469710 · Cited by 1 · see citing works
Locskai, L. F., Ghassemi, S., Tan, S. A. W., Kinley, M. J., & Allison, W. T. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116014 · Cited by 1 · see citing works
Self-citationKöcher, L., Beppi, C., Penner, M., Meyer, S., Bögli, S. Y., & Straumann, D. (2024) · Brain Communications · doi:10.1093/braincomms/fcae407 · Cited by 1 · see citing works
Alkhatib, L. M. T., Zerulla, T. C., Finlay, K. M., & Allison, W. T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.31.742143 · Cited by 1 · see citing works
Self-citationVisualizing traumatic brain injuries
Ekker, M. (2021) · eLife · doi:10.7554/elife.65676
Probing Traumatic Brain Injury Pathophysiology: Lessons from the Zebrafish Model
Mohamed, W. M. Y., & Kobeissy, F. H. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-6341-2_2
Navarrete, C. M., García‐Martín, A., Correa-Sáez, A., Prados, M. E., Fernández, F., Pineda, R., Mazzone, M., Benito, M. Á., Calzado, M. A., & Muñoz, E. (2022) · Figshare · doi:10.6084/m9.figshare.20282208
Posttraumatic epilepsy: Pathophysiology, clinical characteristics and disease within lifespan
Stefan, H., & Hammen, T. (2026) · Seizure · doi:10.1016/j.seizure.2026.07.016
Bergamo, G., Fernandes, M., Maio, S., Albanesi, G., Antonucci, M., Barbaro, I. Y. A. N., Cirillo, F., Fernando, L., Amicucci, G., Centonze, D., et al. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112237
Ghassemi, S., Penetrante, X., Zerulla, T. C., Hamilton, T. J., & Allison, W. T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.12.751143
Self-citation
- Authors
- Alyenbaawi, H., Kanyo, R., Locskai, L. F., Kamali-Jamil, R., DuVal, M. G., Bai, Q., Wille, H., Burton, E. A., & Allison, W. T.
- Affiliations
- University of Alberta (CA)
- University of Pittsburgh (US)
- Corresponding author
- Allison, W Ted
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2021-02-02
- Volume
- 10
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC7853719
- OpenAlex
- W3126875969
- Cited by
- 40
- References
- 100
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 1
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Alberta Innovates - Health Solutions
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Alberta Innovates Bio Solutions (201700005, 201700018)
- Anonymous Donors
- National Institutes of Health (NS080881)
- CurePSP (655-2018-06 and 468-08)
- U.S. Department of Veterans Affairs (BX003168)
- Majmaah University
- Saudi Arabia Cultural Bureau in Ottawa
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- traumatic brain injury, tauopathy, chronic traumatic encephalopathy, post-traumatic seizures, tau aggregation, prion-like seeding, dynamin inhibitors, antiepileptic drugs, zebrafish model, neurodegeneration, cell death
- MeSH terms
- Brain Injuries, Traumatic, Animals, Anticonvulsants, Larva, Seizures, Zebrafish, tau Proteins, Cell Death, Tauopathies, Animals, Genetically Modified, Dynamins, Green Fluorescent Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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