Microglia: Friend and foe in tauopathy

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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

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Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

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Physiology of Microglia

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<i>TREM2</i> Variants in Alzheimer's Disease

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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IgG Subclasses and Allotypes: From Structure to Effector Functions

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Identification of a unique TGF-β–dependent molecular and functional signature in microglia

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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Matrix metalloproteinases and other matrix proteinases in relation to cariology: the era of dentin degradomics

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

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Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

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Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

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Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

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Transmission and spreading of tauopathy in transgenic mouse brain

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Alzheimer’s disease drug-development pipeline: Few candidates, frequent failures

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Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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Heparan Sulfate ProteoglycansPreprint

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Impairment of paravascular clearance pathways in the aging brain

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Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

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Cysteine cathepsins: From structure, function and regulation to new frontiers

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Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

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Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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Propagation of Tau Misfolding from the Outside to the Inside of a Cell

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Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

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Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

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PET Imaging of Tau Deposition in the Aging Human Brain

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Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

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The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

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In-vivo measurement of activated microglia in dementia

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Cytotoxicity of microglia

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The Cell Biology of Phagocytosis

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Regulatory evolution of innate immunity through co-option of endogenous retroviruses

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Trans-Synaptic Spread of Tau Pathology In Vivo

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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

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Role of Particle Size in Phagocytosis of Polymeric Microspheres

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

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Neuronal activity enhances tau propagation and tau pathology in vivo

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

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Neuronal ‘On’ and ‘Off’ signals control microglia

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Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease

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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

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Macropinocytosis: an endocytic pathway for internalising large gulps

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Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

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Proteopathic tau seeding predicts tauopathy in vivo

Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M., & Diamond, M. I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411649111 · Cited by 696 · see citing works

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Friedman, B. A., Srinivasan, K., Ayalon, G., Meilandt, W. J., Lin, H., Huntley, M. A., Cao, Y., Lee, S.-H., Haddick, P. C. G., Ngu, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.066 · Cited by 662 · see citing works

Membrane flow during pinocytosis. A stereologic analysis.

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Bhaskar, K., Konerth, M., Kokiko-Cochran, O. N., Cardona, A., Ransohoff, R. M., & Lamb, B. T. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.023 · Cited by 639 · see citing works

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

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Tau protein aggregation is associated with cellular senescence in the brain

Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell · doi:10.1111/acel.12840 · Cited by 595 · see citing works

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

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Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

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Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.046 · Cited by 574 · see citing works

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway

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Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

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Phagocytosis: A Fundamental Process in Immunity

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LRP1 is a master regulator of tau uptake and spread

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Tau promotes neurodegeneration through global chromatin relaxation

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TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

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Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

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Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

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Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

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