Metformin 2,500 mg/day in the treatment of obese women with polycystic ovary syndrome and its effect on weight, hormones, and lipid profile
Abstract
Purpose The objective of this study was to assess the efficacy and safety of metformin at the dosage of 2,500 mg/day in the treatment of obese women with PCOS and also to evaluate its effect on weight, hormones, and lipid profile.Method This study was a 4-month open-label clinical trial. Sixty-nine PCOS patients aged 20-35 were recruited in the study. Testosterone, free testosterone, sex hormone-binding globulin (SHBG), fasting insulin, dehydroepiandrostenedione-sulphate (DHEAS), FBS, LDH, HDL, TG, total cholesterol, body mass index (BMI), and waist-to-hip ratio were measured before treatment and after 4 months of treatment.Results Significant reductions in serum insulin, BMI, waist/hip ratio, and LDL were observed. In addition, a significant increase in SHBG was obtained. Over the 4 months of the trial, 12 patients faced nausea, six patients had bloating, five patients had diarrhea and two had headache; none of these symptoms were severe except for two cases that dropped out due to severe vomiting.Conclusion The results of this study show that 2,500 mg daily dose of metformin in obese patients with PCOS is effective in the reduction of BMI, waist hip/ratio, LDL, serum insulin and increases SHBG. In general this dose was relatively safe and well tolerated.
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Metformin's effect on weight in women with PCOS is not as well defined and depends on the population and study design.
“Metformin’s effect on weight in women with PCOS is not as well defined, depending on the population and study design (69–74).”
From GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin (2020) · cites this paper as [74]
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GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin
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- Authors
- Aghahosseini, M., Aleyaseen, A., Safdarian, L., Moddaress-Hashemi, S., Mofid, B., & Kashani, L.
- Affiliations
- Shariati Hospital (IR)
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Kashani, Ladan
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2010-07-02
- Volume
- 282
- Issue
- 6
- Pages
- 691-694
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W1975901376
- Cited by
- 12
- References
- 20
- Citations by year
- 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- metformin, polycystic ovary syndrome, obesity, insulin, sex hormone-binding globulin, lipid profile, body mass index, waist-to-hip ratio, testosterone, drug safety
- MeSH terms
- Adult, Body Weight, Female, Hormones, Humans, Hypoglycemic Agents, Lipids, Metformin, Obesity, Polycystic Ovary Syndrome, Young Adult
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