Cited by 37Ovarian cancer diagnosis and treatmentEndometriosis Research and TreatmentGynecological conditions and treatments

Highly elevated serum CA-125 levels in patients with non-malignant gynecological diseases

He, Rong-Huan, Yao, Wei-Miao, Wu, Li-Yan, Mao, Yu-Yan·2011·Archives of Gynecology and Obstetrics

Abstract

Purposes To identify patients with highly elevated serum CA-125 levels and analyze their clinical characteristics.Methods Patients with non-malignant gynecologic disease (NMGDs, n = 41), in whom serum CA-125 levels were over 1,000 IU/ml were retrospectively enrolled in the study. Seventy-one patients with epithelial ovarian cancer (EOC), in whom, serum CA-125 levels were over 1,000 IU/ml were included as the comparison group. Clinical parameters were compared between the two groups.Results In NMGDs group, 43.90% of the patients had endometriosis. The median of serum CA-125 level in NMGDs was much lower than that of EOC subjects (P < 0.001). Compared to EOC group, the patients in NMGDs group were much younger (P < 0.001) and had fewer histories of pelvic masses (P < 0.001) but had more clinical complaints such as acute abdominal symptoms (P < 0.001) and/or abnormal vaginal bleeding (P = 0.022). Clinical progresses of these two groups were correlated with changes of serum CA-125 levels by follow-up for up to 386 days.Conclusions High levels of serum CA-125 were found not only in the EOC, but also in some NMGDs, especially in the reproductive patients with complaints of acute abdomen symptoms or abnormal vaginal bleeding.

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Crossref · 10.1007/s00404-010-1717-5

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  • CA-125 is not specific for endometriosis, being a tumor marker elevated in ovarian cancer.

    “However, CA-125 is not specific for endometriosis, being a tumor marker elevated in ovarian cancer [37, 38].”

    From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [38]

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Authors
He, R.-H., Yao, W.-M., Wu, L.-Y., & Mao, Y.-Y.
Affiliations
Women's Hospital, School of Medicine, Zhejiang University (CN)
Venue
Archives of Gynecology and Obstetrics
Published
2010-11-11
Volume
283
Issue
S1
Pages
107-110
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
OpenAlex
W1987604627
Cited by
37
References
13
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 4
FWCI
4.17
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
CA125, serum tumor markers, endometriosis, epithelial ovarian cancer, acute abdominal symptoms, abnormal vaginal bleeding, pelvic mass, disease progression
MeSH terms
Abdomen, Acute, Adult, Age Factors, Endometriosis, Female, Genital Diseases, Female, Humans, Leiomyoma, Membrane Proteins, Middle Aged, Retrospective Studies, Uterine Hemorrhage, Case-Control Studies, CA-125 Antigen

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