Highly elevated serum CA-125 levels in patients with non-malignant gynecological diseases
Abstract
Purposes To identify patients with highly elevated serum CA-125 levels and analyze their clinical characteristics.Methods Patients with non-malignant gynecologic disease (NMGDs, n = 41), in whom serum CA-125 levels were over 1,000 IU/ml were retrospectively enrolled in the study. Seventy-one patients with epithelial ovarian cancer (EOC), in whom, serum CA-125 levels were over 1,000 IU/ml were included as the comparison group. Clinical parameters were compared between the two groups.Results In NMGDs group, 43.90% of the patients had endometriosis. The median of serum CA-125 level in NMGDs was much lower than that of EOC subjects (P < 0.001). Compared to EOC group, the patients in NMGDs group were much younger (P < 0.001) and had fewer histories of pelvic masses (P < 0.001) but had more clinical complaints such as acute abdominal symptoms (P < 0.001) and/or abnormal vaginal bleeding (P = 0.022). Clinical progresses of these two groups were correlated with changes of serum CA-125 levels by follow-up for up to 386 days.Conclusions High levels of serum CA-125 were found not only in the EOC, but also in some NMGDs, especially in the reproductive patients with complaints of acute abdomen symptoms or abnormal vaginal bleeding.
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CA-125 is not specific for endometriosis, being a tumor marker elevated in ovarian cancer.
“However, CA-125 is not specific for endometriosis, being a tumor marker elevated in ovarian cancer [37, 38].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [38]
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- Authors
- He, R.-H., Yao, W.-M., Wu, L.-Y., & Mao, Y.-Y.
- Affiliations
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2010-11-11
- Volume
- 283
- Issue
- S1
- Pages
- 107-110
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W1987604627
- Cited by
- 37
- References
- 13
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- CA125, serum tumor markers, endometriosis, epithelial ovarian cancer, acute abdominal symptoms, abnormal vaginal bleeding, pelvic mass, disease progression
- MeSH terms
- Abdomen, Acute, Adult, Age Factors, Endometriosis, Female, Genital Diseases, Female, Humans, Leiomyoma, Membrane Proteins, Middle Aged, Retrospective Studies, Uterine Hemorrhage, Case-Control Studies, CA-125 Antigen
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