Trace elements and oxidative stress in hypertensive disorders of pregnancy
Abstract
Purpose Due to increased metabolic requests, pregnancy can be considered as metabolic stress, especially if associated with oxidative stress triggered by disbalance of pro/antioxidants. The aim of the study was to determine serum concentrations of the trace elements iron (Fe), zinc (Zn) and copper (Cu) important in growth regulation and pro/anti-oxidant homeostasis, in relation to the total serum oxidant capacity (TOC) and total serum antioxidant capacity (TAC) in pregnant women with preeclampsia (n = 30) or with gestational hypertension (n = 30) and in healthy pregnant women (n = 37) and non-pregnant women (n = 30) as control groups expecting common differences between all pregnant women and controls and between preeclampsia and the other pregnancies indicating specific disbalance of the oxidative stress and analyzed trace elements.Methods Serum Fe was determined by spectrophotometric method, Cu and Zn were determined by atomic absorption spectrometry, TOC was determined by Enzymatic ANTIOX-CAP assay and TAC by Peroxide-activity assay.Results Serum Cu and TOC were significantly higher while Zn was lower in all pregnant groups regardless of hypertensive disorders. Serum Fe and TAC concentrations were found to be significantly higher in pregnant women with preeclampsia compared to pregnant controls.Conclusion Increase of TOC in all pregnant women our study points to latent oxidative stress in pregnancy. Fe might have a role in etiopathogenesis of preeclampsia while the increase of TAC in the very beginning of preeclampsia might represent a stressdefence mechanism of the body. It has still to be revealed whether significantly higher serum Fe levels are associated with preeclampsia as a cause or as a consequence of this disorder.
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Higher serum iron levels measured at 20 weeks of gestation were found in women with preeclampsia but not gestational hypertension than in women with normotensive pregnancies.
“Another study indicated higher serum iron levels measured at 20 weeks of gestation in women with preeclampsia but not gestational hypertension than in women with normotensive pregnancies [32].”
From Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: a population‐based study (2021) · cites this paper as [32]
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- Authors
- Fenzl, V., Flegar-Meštrić, Z., Perkov, S., Andrišić, L., Tatzber, F., Žarković, N., & Duić, Ž.
- Affiliations
- Klinička bolnica Merkur (HR)
- University of Zagreb (HR)
- Ruđer Bošković Institute (HR)
- University of Applied Sciences Technikum Wien (AT)
- University of Rijeka (HR)
- Corresponding author
- Fenzl, Vanja
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2012-08-10
- Volume
- 287
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2014199787
- Cited by
- 61
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 15 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 2 · 2013: 4
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- hypertensive disorders of pregnancy, preeclampsia, gestational hypertension, oxidative stress, trace elements, iron, zinc, copper, antioxidant capacity, serum trace element concentrations, pregnancy
- MeSH terms
- Adult, Antioxidants, Copper, Female, Humans, Iron, Peroxides, Pre-Eclampsia, Pregnancy, Prospective Studies, Trace Elements, Zinc, Oxidants, Oxidative Stress, Hypertension, Pregnancy-Induced
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