Soluble c-Met expression in the peritoneal fluid and serum of patients with different stages of endometriosis
Abstract
Introduction Hepatocyte growth factor (HGF), also known as scatter factor, and its receptor c-Met have been shown to be implicated in endometriosis. HGF acts as a mitogen, motogen, and morphogen on endometrial epithelial cells. The expression of c-Met on human endometrial cells has been reported. Many proteins are proteolytically released from the surface by a process known as ectodomain shedding. The aim of this study was to determine the levels of soluble c-Met (s-cMet) in the peritoneal fluid (PF) and serum samples of patients with different stages of endometriosis.Material and methods 39 PF and serum samples from normal healthy and 130 samples from different stages of patients with endometriosis (33 cases of stage I, 38 stage II, 30 stage III and 29 stage IV) were included in this study. Total protein concentration (TPC) and the level of s-cMet in the PF and serum were determined by Bio-Rad protein assay based on the Bradford dye procedure and enzyme-linked immunosorbent assay, respectively.Results No significant change in the TPC was seen in the serum and PF of patients with endometriosis when compared with normal controls. Results obtained demonstrated that all PF and serum samples presented s-cMet expression, whereas, starting from stages I to IV endometriosis, a significant increase of s-cMet expression was observed as compared to controls.Conclusion The results of this study show that a high expression of s-cMet is correlated with advanced stages of endometriosis. It is also concluded that the detection of serum and PF s-cMet may be useful in classifying endometriosis.
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Serum c-Met was significantly higher in endometriosis patients (n=130) than in controls (n=39), in a stage dependent manner.
“The serum concentration of its receptor, c-Met, was significantly higher in endometriosis patients (n = 130) than in controls (n = 39), in a stage dependent manner [74].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [74]
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Update on biomarkers for the detection of endometriosis
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“The serum concentration of its receptor, c-Met, was significantly higher in endometriosis patients (n = 130) than in controls (n = 39), in a stage dependent manner [74].”
- Authors
- KhoshdelRad, N., Salehi, Z., Mashayekhi, F., Abbasi, O., & Mirzajani, E.
- Affiliations
- University of Guilan (IR)
- Guilan University of Medical Sciences (IR)
- Corresponding author
- Mashayekhi, Farhad
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2013-11-12
- Volume
- 289
- Issue
- 5
- Pages
- 1107-1112
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W1975658658
- Cited by
- 17
- References
- 29
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, hepatocyte growth factor, c-Met, peritoneal fluid, serum biomarkers, endometriosis stage, ectodomain shedding, endometrial epithelial cells
- MeSH terms
- Adult, Analysis of Variance, Ascitic Fluid, Endometriosis, Enzyme-Linked Immunosorbent Assay, Female, Humans, Middle Aged, Severity of Illness Index, Socioeconomic Factors, Case-Control Studies, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met
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