Role of cytokines in endometriosis
Open accessAbstract
Objective To review the literature on the role of cytokines in the pathogenesis of endometriosis and endometriosis-associated infertility.Design Pertinent studies were identified by a computer search of MEDLINE. References of selected articles were hand-searched for additional citations.Result(s) Recent studies suggest that the peritoneal fluid of women with endometriosis contains an increased number of activated macrophages that secrete various local products, such as growth factors and cytokines. Levels of several cytokines were reported to be elevated in the peritoneal fluid of women with endometriosis. Because the peritoneal environment may be controlled by locally regulated factors, cytokines are believed to play a role in the development and progression of endometriosis and endometriosis-associated infertility. A possible pathogenic mechanism links cytokines with endometriosis.Conclusion(s) Cytokines, which are produced by many cell types including endometriotic tissues, play diverse roles in the pathogenesis of endometriosis and endometriosis-associated infertility. More studies about the specific role of these cells and soluble factors are needed to improve understanding of endometriosis and to develop novel therapies.
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Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of many different cytokines and angiogenic factors.
“Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [70]
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- Authors
- Harada, T., Iwabe, T., & Terakawa, N.
- Affiliations
- Tottori University (JP)
- Corresponding author
- Harada, Tasuku
- ORCID
- Harada, Tasuku
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 76
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2049657573
- Cited by
- 567
- References
- 111
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 20 · 2023: 22 · 2022: 18 · 2021: 23 · 2020: 19 · 2019: 21 · 2018: 19 · 2017: 29 · 2016: 22 · 2015: 19 · 2014: 24 · 2013: 28 · 2012: 32
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, cytokines, endometriosis-associated infertility, peritoneal fluid, macrophages, endometriosis pathogenesis, growth factors, peritonitis
- MeSH terms
- Ascitic Fluid, Endometriosis, Female, Humans, Infertility, Female, Cytokines
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